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1. Comparison of the Pharmacological Activity and Safety of 1-Adamantylguanidine and 3,5-Dimethyl-1-Adamantylguanidine to those of Memantine

   Guanidine-containing analogs of amantadine and memantine, including 1-adamantylguanidine hydrochloride (IEM-2151) and...

   V. E. Gmiro, S. E. Serdyuk in Pharmaceutical Chemistry Journal

   Article 08 March 2021
   

2. Preparation of Cinnamon-Coated Cerium Oxide Nanoparticles and Evaluation of their Anticonvulsant Effect in Rats

   This study was aimed at evaluating the effects of cinnamon-coated cerium oxide nanoparticles as a new drug for treatring pentylenetetrazole-induced...

   Fatemeh Mojarrad, Asadollah Asadi, ... Saber Zahri in Pharmaceutical Chemistry Journal

   Article 01 August 2023
   

3. Grape seed proanthocyanidins protect retinal ganglion cells by inhibiting oxidative stress and mitochondrial alteration

   Grape seed proanthocyanidins (GSP) are known as condensed tannins and have been used as an anti-oxidant in various neurodegenerative diseases. In our...

   Linlin Li, **ng Geng, ... Qin Wang in Archives of Pharmacal Research

   Article 19 October 2020
   

4. Effects of Aminoadamantane Derivatives on Morphine-Induced Analgesia in Mice

   The effects of low-affinity NMDA-receptor antagonists amantadine (1-aminoadamantane hydrochloride) and hemantane [ N -(2-adamantyl)hexamethyleneimine...

   L. G. Kolik, A. V. Nadorova, ... E. A. Val’dman in Pharmaceutical Chemistry Journal

   Article 17 July 2020
   

5. L-proline transporter inhibitor (LQFM215) promotes neuroprotection in ischemic stroke

   Background

   L-proline transporter (PROT/SLC6A7) is closely associated with glutamatergic neurotransmission, where L-proline modulates the NMDA receptor...

   Gustavo Almeida Carvalho, Raphaela Almeida Chiareli, ... Mauro Cunha Xavier Pinto in Pharmacological Reports

   Article 31 January 2023
   

6. Recent Advances in the Pharmacological Properties and Molecular Mechanisms of Carvacrol

   Plant secondary metabolites have received a lot of attention for their immense pharmacological activities and low side effects. Monoterpenes,...

   Tabasum Ali, Sheikh Tahir Majeed, ... Khurshid Iqbal Andrabi in Revista Brasileira de Farmacognosia

   Article 02 August 2023
   

7. Exploring molecular mechanisms, therapeutic strategies, and clinical manifestations of Huntington’s disease

   Huntington’s disease (HD) is a paradigm of a genetic neurodegenerative disorder characterized by the expansion of CAG repeats in the HTT gene. This...

   Alaa Shafie, Amal Adnan Ashour, ... Md. Imtaiyaz Hassan in Archives of Pharmacal Research

   Article 19 May 2024
   

8. Analysis of Eleutherosides by Tandem Mass Spectrometry: Possibilities of Standardizing a Multi-Phytoadaptogen Formulation for Preventive Oncology

   The major bioactive constituents in extracts from roots of Eleutherococcus senticosus (Rupr. & Maxim) (Araliaceae) and in a multi-adaptogen herbal...

   O. A. Bocharova, V. E. Shevchenko, ... V. S. Kosorukov in Pharmaceutical Chemistry Journal

   Article 20 September 2022
   

9. New benzimidazole-aldehyde hybrids as neuroprotectors with hypochlorite and superoxide radical-scavenging activity

   Background

   Many neurodegenerative disorders include oxidative stress-mediated pathology. Melatonin and its metabolites act as endogenous reactive...

   Neda Anastassova, Denitsa Yancheva, ... Magdalena Kondeva-Burdina in Pharmacological Reports

   Article 03 March 2020
   

10. Exploring the therapeutic potential of natural compounds modulating the endocannabinoid system in various diseases and disorders: review

    Cannabinoid receptors, endogenous cannabinoids (endocannabinoids), and the enzymes involved in the biosynthesis and degradation of the...

    Gidion Wilson, Lingling Yang, ... Xueqin Ma in Pharmacological Reports

    Article 31 October 2023
    

11. Olanzapine alters the expression of gasotransmitter-related enzymes: CBS and HO-2 in the rat hippocampus and striatum

    Background

    Gaseous neurotransmitters have been thought to be novel factors involved in the mechanisms of mental disorders pathogenesis for quite some...

    Artur Pałasz, Julia Kistowska, ... Katarzyna Bogus in Pharmacological Reports

    Article Open access 24 October 2023
    

12. New triterpenoids from Staphylea bumalda flower buds and their neuroprotective activity against H₂O₂-induced injury in vitro

    Four new acylated triterpene glycosides with aliphatic chains ( 4 – 7 ) as well as five known triterpenoids were isolated from the flower buds of Staphylea...

    Zheng-** Zhang, Kun Feng, ... **ao-Fei Chen in Archives of Pharmacal Research

    Article 30 October 2018
    

13. A Potential Method for Standardization of Multiphytoadaptogen: Tandem Mass Spectrometry for Analysis of Biologically Active Substances from Rhodiola rosea

    Tandem mass spectrometry (HPLC-MS/MS) was used to analyze biologically active compounds in extracts of the tuber and roots of Rhodiola rosea (family Crassulaceae...

    O. A. Bocharova, I. V. Kazeev, ... I. S. Stilidi in Pharmaceutical Chemistry Journal

    Article 09 April 2022
    

14. Pharmacological Activities and Pharmacokinetics of Glycycoumarin

    Glycycoumarin is a representative coumarin compound with significant pharmacological activities isolated from Glycyrrhiza uralensis Fisch., Fabaceae....

    Yumei Tang, Shui** Ou, ... Sen Wang in Revista Brasileira de Farmacognosia

    Article 16 December 2022
    

15. Potential drugs for the treatment of Alzheimer’s disease

    It is well known that amyloid precursor protein (APP), the enzyme β-secretase 1 (BACE1), cyclooxygenase 2 (COX-2), nicastrin (NCT), and...

    Tania Guadalupe Montero-Cosme, Luz Irene Pascual-Mathey, ... Gonzalo Emiliano Aranda-Abreu in Pharmacological Reports

    Article 01 April 2023
    

16. Synthesis of New Conjugates of Edaravone and 1-Aminoadamantanes and Their Interaction with NMDA Receptors in Rats

    New adamantane-containing derivatives of edaravone, one of two drugs used to treat amyotrophic lateral sclerosis, were synthesized. The pyrazolone...

    V. V. Grigoriev, A. Yu. Aksinenko, ... T. A. Epishina in Pharmaceutical Chemistry Journal

    Article 01 May 2024
    

17. Mechanistic insights on TLR-4 mediated inflammatory pathway in neurodegenerative diseases

    Neurodegenerative diseases (NDDs) pose a significant issue in healthcare, needing a thorough knowledge of their complex molecular mechanisms. A...

    Veerta Sharma, Prateek Sharma, Thakur Gurjeet Singh in Pharmacological Reports

    Article 25 June 2024
    

18. Mitochondrial connection to ginsenosides

    Mitochondria play an essential role in energy synthesis and supply, thereby maintaining cellular function, survival, and energy homeostasis via...

    Feng Wang, Yoon Seok Roh in Archives of Pharmacal Research

    Article 28 October 2020
    

19. Production and therapeutic use of astaxanthin in the nanotechnology era

    Abstract

    Astaxanthin (AXT) is a red fat-soluble pigment found naturally in aquatic animals, plants, and various microorganisms and can be manufactured...

    Karim Abdelazim, Amr Ghit, ... Ahmed Hussein in Pharmacological Reports

    Article Open access 13 May 2023
    

20. Sclareol: Isolation, Structural Modification, Biosynthesis, and Pharmacological Evaluation – A Review

    Sclareol, isolated from a variety of plant species like Salvia sclarea , is a labdane diterpene of high value for the flavour and fragrance...

    Salman Jameel, Khursheed Ahmad Bhat in Pharmaceutical Chemistry Journal

    Article 01 January 2024