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Development and Validation of LC-PDA Method for the Estimation of Doravirine and Related Impurities
The objective of the present research is to develop a reliable, sensitive, and robust stability-indicating RP-HPLC method to quantify doravirine...
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Effect of Tin(II) Chloride Amount on 99mTc-Labeling of One 6-Hydrazinonicotinamide-Conjugated Peptide in the Presence of Tricine/Nicotinic Acid
The use of tin(II) chloride in amount above its required mole ratio as reducing agent can lead to instability of peptide-based radiopharmaceuticals....
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Antibody drug conjugates as targeted cancer therapy: past development, present challenges and future opportunities
Antibody drug conjugates (ADCs) are promising cancer therapeutics with minimal toxicity as compared to small cytotoxic molecules alone and have shown...
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Ternary Solid Dispersion of Celecoxib Produced by the Solvent Method with Improved Solubility and Dissolution Properties
Celecoxib, the first cyclooxygenase-2 selective nonsteroidal anti-inflammatory drug, has a wide range of pharmacological effects, including...
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Eye
In this chapter several aspects of ocular dosage forms are discussed with emphasis on eye drops, eye lotions and eye ointments prepared in...
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Scope and challenges of nanoparticle-based mRNA delivery in cancer treatment
Messenger RNA (mRNA) recently emerged as an appealing alternative to treat and prevent diseases ranging from cancer and Alzheimer’s disease to...
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Production and therapeutic use of astaxanthin in the nanotechnology era
AbstractAstaxanthin (AXT) is a red fat-soluble pigment found naturally in aquatic animals, plants, and various microorganisms and can be manufactured...
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Radiocomplexation, Chromatographic Separation and Bioevaluation of [99mTc]Dithiocarbamate of Procainamide as Selective Labeled Compound for Myocardial Perfusion Imaging
Cardiac imaging is one of the most important tools for diagnosing many diseases related to the heart. This work was devoted to develo** this method...
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Raw Materials
Raw materials for pharmaceutical preparations are either active substances (or active pharmaceutical ingredients (APIs)) or excipients. The choice of...
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Liquid chromatography–tandem mass spectrometry method for mycophenolic acid and its glucuronide determination in saliva samples from children with nephrotic syndrome
BackgroundSaliva sampling is one of the methods of therapeutic drug monitoring for mycophenolic acid (MPA) and its metabolite, mycophenolic acid...
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Chemical and Biological Aspects of Solanum paniculatum Roots
Here we report the most complete study of a plant used for culinary and medicinal purposes. This study was conducted with Solanum paniculatum L.,...
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Dysregulation of histone deacetylases in ocular diseases
Ocular diseases are a growing global concern and have a significant impact on the quality of life. Cataracts, glaucoma, age-related macular...
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Calibration Methods and Procedures
A set of procedures known as calibration establishes the relationship between the values reported by a measuring device or measuring system and the...
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HPTLC Method Development for Estimation of Vasicine in Herbal Extract and its Marketed Formulations
Adhatoda vasica Nees, is locally known as adulsa, which is used in various medicinal activities. Hence, an objective of the study was to develop an...
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Deuterated Drugs
A deuterated drug comprises diminutive molecules in which deuterium replaces one or more than one hydrogen atoms of the molecule. As deuterium and...
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Containers
Packaging is an integral part of any medicinal product. Not only from a regulatory point of view, but also that of the patient. It is only the...
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Development and Evaluation of Topical Liposome Preparation of Flax Seed Oil and Tamarind Seed Oil against Skin-Protective Activity
The current study focuses on exploring the traditional system of medicine in the field of pharmaceutics to achieve the combined effect of flax seed...
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Statistical Optimization of Spray-Dried Extract from Leaves of Croton blanchetianus: Simplex Centroid and Factorial Design as Basic Tools
Studies have reported that Croton blanchetianus Baill., Euphorbiaceae, has anti-inflammatory effects triggered by the presence of polyphenols. With...
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A Retrospective Analysis of Applications for Registration of Generic Medicines Processed by the Medicines Control Authority of Zimbabwe
BackgroundMany applications for registration of medicines are rejected because applicants fail to submit or resolve critical deficiencies in the...
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EGF, a veteran of wound healing: highlights on its mode of action, clinical applications with focus on wound treatment, and recent drug delivery strategies
Epidermal growth factor (EGF) has been used in wound management and regenerative medicine since the late 1980s. It has been widely utilized for a...
