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Design, Synthesis, and Pharmacological Activity of a New Matrix Metalloproteinase-9 Inhibitor
The new MMP-9 inhibitor 1-{4-[(4-chlorobenzoyl)amino]phenyl}sulfonyl-L-proline, with a theoretical inhibition constant of IC 50 = 4 × 10 5 M, was...
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First Ionic Conjugates of Dihydroquercetin Monosuccinate with Amines
The reaction of dihydroquercetin monosuccinate with ammonia, a series of alkylamines, and amino-derivatives of heterocyclic compounds including...
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DISCUSSION OF HERBAL DRUGS BASED ON THE BIOGENETIC CLASSIFICATION OF THEIR MAIN ACTIVE COMPONENTS
Honey is prepared by honey-bees (Apis mellifera) from the nectar and honeydew of flowers. After chemical conversion by the gastric juices in the...
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Determination and Degradation Study of Enalapril Maleate by High Performance Liquid Chromatography
Enalapril maleate belongs to the group angiotensin-converting enzyme inhibitors used in the treatment of hypertension and heart failure. In this...
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Synthesis, Antihelminthic and Insecticidal Activity of 2-[3-Methyl-6-Methoxy-7-(n-Propoxy)-3,4-Dihydroisoquinolin-1]Ethanoic Acid Amides
Cyclocondensation of O- n -propylated eugenol with cyanoacetamides was used to synthesize 2-[3-methyl-6-methoxy-7-( n -propoxy)-3,4-dihydroisoquinolin-1]e...
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Studies of the benzopyran class of selective COX-2 inhibitors using 3D-QSAR and molecular docking
AbstractThe Gaussian-based 3D-QSAR studies for 58 selective COX-2 (cyclooxygenase-2) inhibitors belonging to benzopyran chemical class were...
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Antinociceptive and pronociceptive effect of levetiracetam in tonic pain model
BackgroundLevetiracetam (LEV) is a novel anticonvulsant with proven antinociceptive properties. However, the antinociceptive and pronociceptive...
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Anti-inflammatory effects of 4-o-methyl-benzenesulfonyl benzoxazolone (MBB) in vivo and in vitro as a novel NSAIDs lead compound
BackgroundGreat attention has been paid to the development of novel anti-inflammatory drugs to overcome the adverse reactions of traditional drugs....
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Synthesis and Anticonvulsive Activity of 5-Pyrrolidin-1-Ylpyrano[4″,3″:4′,5′]Pyrido-3′,2′:4,5]Thieno[3,2-D]Pyrimidine Derivatives
A method for preparing the amino, alkoxy, and alkylsulfanyl derivatives of pyrano[4″,3″:4′,5′]pyrido-[3′,2′:4,5]thieno[3,2- d ]pyrimidines based on...
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Collision-induced dissociation pathways of H1-antihistamines by electrospray ionization quadrupole time-of-flight mass spectrometry
Over the past decades, mass spectrometry technologies have been developed to obtain mass accuracies of one ppm or less. Of the newly developed...
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Involvement of brain natriuretic peptide signaling pathway in the cardioprotective action of sitagliptin
BackgroundThe current study is focusing on the role of brain natriuretic peptide (BNP), a substrate of dipeptidyl peptidase-4 (DPP-4) enzyme, and its...
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Organic Hydrogen Sulfide Donor Compounds with Cardioprotective Properties (Review)
This review summarizes published data on organic hydrogen sulfide donor compounds, including hybrid compounds, and their roles in cardioprotection.
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Synthesis and in vitro anticancer activity of new 2-thioxo-oxazolidin-4-one derivatives
BackgroundOxazolidinones derivatives exhibit different biological properties, including anticancer activity. This work aimed to investigate the...
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Linear diarylheptanoids as potential anticancer therapeutics: synthesis, biological evaluation, and structure–activity relationship studies
In efforts to develop effective anticancer therapeutics with greater selectivity toward cancerous cell and reduced side-effects, such as emetic...
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Antinociceptive properties of N-Mannich bases derived from 3-substituted pyrrolidine-2,5-dione in the formalin model of persistent pain in mice
BackgroundAccumulated data indicate that anticonvulsants possess antinociceptive properties in rodent pain models. In view of the anticonvulsant...
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Modified Coumarins. 38. Synthesis and Cytotoxicity of 6-Pyrazolinylcoumarins
The synthesis of 6-[5-aryl-4,5-dihydropyrazol-3-yl]-5-hydroxy-7-methylcoumarins is reported. The anticancer activities of the synthesized compounds...
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QSAR based therapeutic management of M. tuberculosis
Mycobacterium tuberculosis is responsible for severe mortality and morbidity worldwide but, under-developed and develo** countries are more prone...
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N-Heterocyclic choline analogues based on 1,2,3,4-tetrahydro(iso)quinoline scaffold with anticancer and anti-infective dual action
BackgroundPharmacological effects of biologically active “small molecules” can be improved by their targeted modification, which affects drug...
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The antiprotozoal potencies of newly prepared 3-azabicyclo[3.2.2]nonanes
3-Azabicyclo[3.2.2]nonanes are already reported as antiprotozoal agents. Structural variations were performed by attachment of several basic side...
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Autophagy in MCF-7 cancer cells induced by copper complexes
BackgroundAutophagy plays an important role in cancer cells. Targeting autophagy in cancer can provide new opportunities for drug development.
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