Search
Search Results
-
A closer look at the 2019 Beers criteria
Increased use of potentially inappropriate medications (PIMs) is one of the major issues arising in older adults. The use of PIMs has been found to...
-
Protective effect of the ethanolic and methanolic leaf extracts of Madhuca longifolia against diclofenac-induced toxicity in female Wistar albino rats
BackgroundDiclofenac is commonly prescribed Non-Steroidal Anti-Inflammatory Drug (NSAIDs) as it has anti-inflammatory, analgesic and anti-pyretic...
-
Pharmacological treatments of COVID-19
The viral infection due to the new coronavirus or coronavirus disease 2019 (COVID-19), which was reported for the first time in December 2019, was...
-
A mixed-methods systematic review of the prevalence, reasons, associated harms and risk-reduction interventions of over-the-counter (OTC) medicines misuse, abuse and dependence in adults
BackgroundOver-the-counter (OTC) medicines are typically safe. However, there is evidence that OTC medicines can sometimes cause harm as a result of...
-
Agomelatine prevents indomethacin-induced gastric ulcer in rats
BackgroundGastric ulcer is a very common gastrointestinal disease that may be dangerous and even may lead to death. The current study was conducted...
-
-
Preparation and In Vitro/Vivo Evaluation of New Celecoxib Solid Dispersions with Co-Carrier Containing Aerosil and Poloxamer 188
Solid dispersions (SDs) containing co-carrier were developed to improve in vitro dissolution and in vivo pharmacokinetics of celecoxib (CXB). Various...
-
Evaluation of levofloxacin utilization in intensive care units of tertiary care hospital: a retrospective observational study
BackgroundThe emergence of antibiotic-resistant bacteria is a major problem throughout the world, and rational use of antibiotics is, therefore, very...
-
Recent and updated pharmacotherapy of migraine
Migraine is a complex and still debatable neurovascular disorder that is on the rise globally, affecting patients of all ages. Various drugs are...
-
Differential effect of LPS and paclitaxel on microglial functional phenotypes and circulating cytokines: the possible role of CX3CR1 and IL-4/10 in blocking persistent inflammation
Neuroinflammation plays a role in cancer chemotherapy-induced chronic pain. Thus far, most studies have focused on neuroinflammation suppression....
-
A prospective observational pilot study of adverse drug reactions contributing to hospitalization in a cohort of middle-aged adults aged 45–64 years
PurposeOur objective was to determine the prevalence, severity and preventability of adverse drug reactions (ADRs), ADRs causing or contributing to...
-
Local Analgesic Activity of Hemantane Gel Dosage Forms Evaluated Using the Formalin Test in Rats
Hemantane is an antiparkinsonian drug with pronounced analgesic and anti-inflammatory properties. The present work evaluated topical gel dosage forms...
-
The safety and efficacy of Guluronic acid (G2013) in ankylosing spondylitis: A randomized controlled parallel clinical trial
BackgroundTo assess the therapeutic efficacy, safety and tolerability of Guluronic acid (G2013) in patients with ankylosing spondylitis (AS) patients.
... -
Appropriateness of postoperative analgesic doses among pediatric surgical patients in a teaching hospital in Northwest Nigeria
BackgroundThe inappropriate and suboptimal use of analgesic drugs is a global problem, and is an area of concern with regard to the management of...
-
Comparative User Testing of Australian and UK Over-the-Counter Labels and Leaflets for Diclofenac
BackgroundLimited research has evaluated the consumer usability of written information available with similar over-the-counter (OTC) products in...
-
The inclusion complex of carvacrol and β-cyclodextrin reduces acute skeletal muscle inflammation and nociception in rats
BackgroundSkeletal muscle inflammation is strongly associated with pain and may impair regeneration and functional recovery after injury. Since...
-
Pharmacological evaluation of 9,10-dihydrochromeno[8,7-e][1,3]oxazin-2(8H)-one derivatives as potent anti-inflammatory agent
BackgroundNon-steroidal anti-inflammatory drugs (NSAIDs) are the most widely administered drugs for the treatment of inflammation. However, they...
-
Defining Efficacy Estimands in Clinical Trials: Examples Illustrating ICH E9(R1) Guidelines
This paper provides examples of defining estimands in real-world scenarios following ICH E9(R1) guidelines. Detailed discussions on choosing the...
-
Safety issues related to the use of prescription drugs in patients with chronic diseases: a bibliographic review
PurposeA literature review was conducted with the aim of investigating the impact of treatments associated with an increased risk of hypertension,...
