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Safety of Linagliptin in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis of Randomized Clinical Trials
BackgroundLinagliptin is an oral dipeptidyl peptidase DPP‐4 inhibitor, which is indicated for the treatment of Type 2 diabetes mellitus (T2DM) as...
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Structure-Based Virtual Screening and Molecular Dynamics Simulation to Identify Potential SARS-CoV-2 Spike Receptor Inhibitors from Natural Compound Database
The outbreak of respiratory disease, COVID-19 caused by SARS-CoV-2 has now been spread globally and the number of new infections is rising every...
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Development of a Bioanalytical Method by UHPLC-ESI-TQD-MS for the Quantification of Digoxin in Plasma
A bioanalytical method was developed and validated for digoxin. The method was extremely sensitive and without adduct formation by ultra-performance...
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Presynaptic antiseizure medications - basic mechanisms and clues for their rational combinations
Among clinically highly efficient antiseizure medications (ASMs) there are modifiers of the presynaptic release machinery. Of them, levetiracetam and...
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Viability of Tumor Cells (K562, Hep-2, HeLa) and Rat Fibroblasts in the Presence of Pterostilbene and Extracts of Licorice Root and Andrographis Paniculata
Results from in vitro studies of the effect of pterostilbene, licorice root extract, and Andrographis paniculata extract on the viability of rat...
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A derivative of 3-(1,3-diarylallylidene)oxindoles inhibits dextran sulfate sodium-induced colitis in mice
BackgroundIA-0130 is a derivative of 3-(1,3-diarylallylidene)oxindoles, which is a selective estrogen receptor modulator (SERM). A previous study...
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Protective Effect of Schisandra chinensis Extract Against Ethanol-Induced Gastric Ulcers in Mice by Promoting Anti-inflammatory and Mucosal Defense Mechanisms
Schisandra chinensis (Turcz.) Baill., Schisandraceae, is a common Chinese traditional medicine for the treatment of nervous system disorders and...
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Essential phospholipids impact cytokine secretion and alter lipid-metabolizing enzymes in human hepatocyte cell lines
BackgroundEssential phospholipids (EPL) are hepatoprotective.
MethodsThe effects on interleukin (IL)-6 and -8 secretion and on certain...
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Recent review of COVID-19 management: diagnosis, treatment and vaccination
The idiopathic Coronavirus disease 2019 (COVID-19) pandemic outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has...
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Dextromethorphan/bupropion in major depressive disorder: a profile of its use
Dextromethorphan/bupropion (AUVELITY ® ), an oral, fixed-dose combination of dextromethorphan hydrobromide and bupropion hydrochloride, is a useful...
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Act quickly to manage bleeding in patients taking direct oral anticoagulants
Direct oral anticoagulants (DOACs) are increasingly preferred anticoagulation options, with a lower risk of intracranial haemorrhage versus warfarin....
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Physiologically based pharmacokinetic (PBPK) modeling of pitavastatin in relation to SLCO1B1 genetic polymorphism
Pitavastatin, a potent 3-hydroxymethylglutaryl coenzyme A reductase inhibitor, is indicated for the treatment of hypercholesterolemia and mixed...
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Liganden für Kanäle, Poren und Transporter
Die Zelle ist die kleinste strukturelle und funktionale Einheit aller Lebewesen. Einzeller bestehen nur aus einer einzigen solchen Einheit. Bei...
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Intestinal drug transporters in pathological states: an overview
Emerging information suggests that gastrointestinal and systemic pathology states may affect expression and function of membrane transporters in the...
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Surface-functionalized curcumin-loaded polymeric nanocapsules could block apomorphine-induced behavioral changes in rats
BackgroundSurface functionalization enhances the properties and characteristics of polymeric nanocapsules (NCs) mainly due to the surface charge,...
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Educate and treat to eliminate gout flares in elderly patients
Gout flares, caused by monosodium urate crystals in joints, are debilitating and linked to poor health outcomes. Gout prevalence increases with age,...
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Somatrogon in paediatric growth hormone deficiency: a profile of its use in the EU
Somatrogon (NGENLA ® ), a modified long-acting form of recombinant human growth hormone (rhGH), is a valuable new option for the treatment of...
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Pharmacokinetic interaction between regorafenib and atorvastatin in rats
BackgroundRegorafenib is used in the treatment of colorectal cancer and hepatocellular carcinoma. Due to the co-morbidity of hyperlipidemia in these...
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The impact of IL-10 and CYP3A5 gene polymorphisms on dose-adjusted trough blood tacrolimus concentrations in early post-renal transplant recipients
BackgroundThe strong inter-individual pharmacokinetic variability and the narrow therapeutic window of tacrolimus (TAC) have hampered the clinical...
