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Diosmetin Alleviates Ovalbumin-Induced Nasal Inflammation by Regulating the SIRT1/NF-κB Signaling in Mouse Models of Allergic Rhinitis
Diosmetin is a flavonoid compound with various pharmacological activities, which plays a vital role in alleviating the development of asthma and...
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Empagliflozin mitigates type 2 diabetes-associated peripheral neuropathy: a glucose-independent effect through AMPK signaling
Diabetic peripheral neuropathy (DPN) represents a severe microvascular condition that dramatically affects diabetic patients despite adequate...
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Therapeutic potential of melatonin in targeting molecular pathways of organ fibrosis
Fibrosis, the excessive deposition of fibrous connective tissue in an organ in response to injury, is a pathological condition affecting many...
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ROCK Kinase Inhibitory Activity of Some Isoflavonoids and Their Pharmacological Significance in Glaucoma
Glaucoma is a chronic inflammatory disorder characterized by the loss of optic nerve fibers and the formation of retinopathy. The redox homeostasis...
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Resveratrol Improves Mechanical Allodynia and Inflammation: Focus on Sex Differences in Rats
Inflammatory pain is a complex phenomenon arising from various etiological factors, resulting in diverse symptoms that can lead to persistent...
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Inhibitors of Nitric Oxide Production from the Seeds of Myristica fragrans: Experimental and Computational Results
This study focuses on the extraction of eleven compounds from Myristica fragrans Houtt., Miristicaceae, seeds, guided by their anti-inflammatory...
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Pharmacological Properties of Acetylsalicylic Acid and its Complex with Glycyrrhizic Acid as a Promising Dosage form (Review)
The review summarizes current literature data on the mechanism of antithrombotic, anti-inflammatory, and antipyretic effects of acetylsalicylic acid...
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Aqueous Extract and Solvent Fractions of Hancornia speciosa Fruits, Rutin, and Chlorogenic Acid Attenuate the Edema, Inflammation, and Myonecrosis Caused by Bothrops jararaca Snake Venom in Mice
Snakebites are considered a neglected tropical disease in Brazil and 70% of cases of envenomation are attributed to the genus Bothrops . The efficient...
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Human milk oligosaccharides 3′-sialyllactose and 6′-sialyllactose attenuate LPS-induced lung injury by inhibiting STAT1 and NF-κB signaling pathways
Acute lung injury (ALI) is the leading cause of respiratory diseases induced by uncontrolled inflammation and cell death. Lipopolysaccharide (LPS) is...
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Azadirone from Toona sinensis possesses anti-inflammatory and analgesic activities via suppressing MAPK signal pathway
This study was designed to investigate the anti-inflammatory, analgesic activity of azadirone from Toona sinensis (Juss.) M. Roem., Meliaceae, and...
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Ishige okamurae Extract: Diphlorethohydroxycarmalol with Effect of Atopic Dermatitis-Like Skin Inflammation
Ishige okamurae Yendo 1907, Fucaceae, a brown alga, has garnered attention for its antipyretic, anti-inflammatory, and anti-edema properties. While...
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Validation of Anti-pyretic-Derived Natural Products and Their Potentials for Drug Discovery
Fever is a complicated process that occurs in response to infection and inflammatory diseases, stimulating the immune system that may cause severe...
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Be alert for macrophage activation syndrome in seriously sick children with underlying pro-inflammatory disorders
Macrophage activation syndrome (MAS) is a serious complication of pro-inflammatory conditions, such as systemic juvenile idiopathic arthritis. MAS...
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Astaxanthin attenuates oxidative stress and inflammatory responses in complete Freund-adjuvant-induced arthritis in rats
BackgroundAstaxanthin (ATX), a natural xanthophyll carotenoid, has shown to exert significant protective effects against various diseases via its...
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Phytochemicals against anti‐diabetic complications: targeting the advanced glycation end product signaling pathway
The role of advanced glycation end products (AGEs) is not limited to diabetes and diabetes-related complications. There are multiple modulators,...
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Overview of COVID-19 inflammatory pathogenesis from the therapeutic perspective
The novel beta coronavirus (SARS-CoV-2, designated as COVID-19) that is responsible for severe acute respiratory syndrome has devastated the global...
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Shionone Relieves Ulcerative Colitis by Regulating the p38 MAPK/NF-κB Pathway
Ulcerative colitis is a serious intestinal disorder, which can lead to a variety of complications, and in severe cases, the risk of becoming...
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Chemistry and Biological Activity of Mustard Oil: Therapeutic Benefits and Risk to Healthcare
Over the years, extensive research on mustard oil has revealed the presence of isothiocyanates as pungent toxic compounds and erucic acids as...
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A novel isoquinoline derivative exhibits anti-inflammatory properties and improves the outcomes of endotoxemia
Background : Sepsis initiates an inflammatory response that causes widespread injury, and candidates for related myocardial depressant factors include...
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Tanshinol Inhibits Periodontitis Through IκBα Promotion
The main pharmacological strategy for the treatment of periodontitis is inhibition of the inflammatory process. The aim of this study was to...
