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Synthesis, Some Transformations, and Biological Properties of 3-Phenethyl-2-Thioxo-2,3-Dihydro-1H-spiro[Benzo[H]Quinazoline-5,1′-Cycloheptane]-4(6H)-Ones
The reaction of ethyl 4′-amino-1′ H -spiro[cycloheptane-1, 2′-naphthalene]-3′-carboxylate with phenethylisothiocyanate followed by cyclization of the...
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Inclusion Complex of 11-deoxymisoprostol and Glycyrrhizic Acid with Improved Anti-Ulcer Activity
A 1:4 inclusion complex of 11-deoxymisoprostol ( II ) with glycyrrhizic acid (complex III ) was synthesized and exhibited high anti-ulcer activity in...
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Synthesis and Antibacterial and Antitumor Activity of 2-Sulfanyl-Substituted 3H-Spiro[Benzo[H]Quinazoline-5,1′-Cycloheptane]-4(6H)-Ones
The reaction of ethyl 4′-amino-1′ H -spiro[cycloheptane-1,2′-naphthalene]-3′-carboxylate with benzoyl isothiocyanate produced ethyl...
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Determination of the Degree of Cinnarizine Incorporation into Soy Lecithin Liposomes
A technique for determining the degree of cinnarizine incorporation in soy lecithin liposomes was developed. Constants of the Freundlich and Langmuir...
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Synthesis and Antidepressant Activity of Thietane-Containing 4-(2-oxo-2-phenylethyl)-1H-1,2,4-triazol-4-ium Bromides
Thietane-containing 4-(2-oxo-2-phenylethyl)-1 H -1,2,4-triazol-4-ium bromides were synthesized by quaternization of thietanyltriazoles with phenacyl...
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Sorption of Some Biologically Active Compounds of Plant Origin on Metal-Organic Frameworks
Results of screening studies of the sorption of naturally occurring biologically active compounds (phenolcarboxylic acids, coumarins, flavonoids, and...
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A New Guaianolide-type Sesquiterpenoid and Xanthine Oxidase Inhibitory Activity from Chrysanthemum sinense Flowers
The ethanol extract of Chrysanthemum sinense Sabine, Asteraceae, flowers was found to inhibit xanthine oxidase with a IC 50 value of...
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Bactericidal and Fungicidal Properties of Some Antiseptic Drugs and Disinfectants
Analytical results for the bactericidal and fungicidal properties of some antiseptic drugs and disinfectants are presented. Regulatory and...
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Antituberculotic Activity of 5-Aryl(Hetaryl)-Methylidene- 2,4,6-Pyrimidine-2,4,6(1H,3H,5H)-Triones and 5-(2-Chloropropylidene)-2,4,6-Pyrimidine-2,4,6(1H,3H,5H)-Triones
The effect of 5-aryl(hetaryl)methylidene-2,4,6-pyrimidine-2,4,6(1 H ,3 H ,5 H )-triones and 5-(2-chloropropylidene)-2,4,6-pyrimidine-2,4,6(1 H ,3 H ,5 H )-triones...
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Hepatoprotective Efficacy of a New Phytocomposition of Essential Phospholipids with Glycyrrhizic Acid, Ecdysterone, and Lycopene in Experimental Chronic Hepatitis Compared to Phosphogliv
A phytocomposition of soy lecithin, glycyrrhizic acid, lycopene, and ecdysterone (conventional name Hepalipin) significantly prevents the development...
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Chemical Constituents and Anti-inflammatory, Antinociceptive, and Antioxidant Activities of Salvia melissiflora Aerial Parts
Chromatographic fractionation of dichloromethane and ethanol extracts of Salvia melissiflora Benth., Lamiaceae, aerial parts led to the...
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Effect of Quercetin and its Derivatives on the Excretory Function of Rat Kidneys
The optimal diuretic doses of quercetin and rutin (5 mg/kg) and dihydroquercetin and hyperoside (1 mg/kg) were determined in experiments on white...
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New Palladium-Containing Polymer Catalysts for the Synthesis of Enalapril
New palladium-containing polymer catalysts for hydrogenating amination of ethyl 2-oxo-4-phenylbutanoate with α-alanyl-α-proline dipeptide were...
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Synthesis and Biological Activity of 5-alkoxy- and 5-amino-substituted 3-bromo-4-nitro-1-(thietan-3-yl)-1H-pyrazoles
5-Alkoxy- and 5-amino-substituted 3-bromo-4-nitro-1-(thietan-3-yl)-1 H -pyrazoles were synthesized by reactions of...
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Synthesis of Heterocyclic Systems 3H-furo[2,3-b]imidazo[4,5-f]quinolines and 3H-furo[2,3-b]pyrazolo[4,3-f]quinolines as New Antibacterial Agents
Along with the current challenges, the need to find new antibiotic compounds is increasing due to the growing antibiotic resistant bacteria. In this...
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Isolation, Characterization and Antibacterial Studies of Three New Chemical Constituents Isolated from Viburnum grandiflorum
Three new compounds “Viburnoate A–C” and two known compounds, namely, 4, 4-dimethyl-hexan-3-ol ( 1 ) and 4- tert -butyl-benzoic acid isobutyl ester ( 2 ) , ...
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Flavonoids of Artemisia argyi
Flavonoids of the aerial part of Chinese mugwort ( Artemisia argyi H. Lev. & Vaniot) were extracted and identified using modern physicochemical...
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Evaluation of the Pharmacotherapeutic Efficacy of Cycloartane Glycosides in Comparison to Lovastatin in Rabbits with Experimental Atherosclerosis
The cycloartane glycosides cyclocarposide and cyclosieversioside F prevent an increase in the blood serum contents of cholesterol, triglycerides, and...
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Alternative Synthesis of Cobimetinib
A novel approach for synthesis of Cobimetinib was reported, avoiding usage of a strong base in any of the steps with a chiral substrate. An efficient...
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Cytotoxic, Antibacterial, and Algaecidal Activity of Copper(II) Complexes of Arylmethylene-Bis(4-Hydroxy-6-Methyl-2H-Pyran-2-Ones)
The in vitro biological properties of previously obtained copper(II) complexes of arylmethylene-bis(4-hydroxy-6-methyl-2 H -pyran-2-ones) were studied....
