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Exploring molecular mechanisms, therapeutic strategies, and clinical manifestations of Huntington’s disease
Huntington’s disease (HD) is a paradigm of a genetic neurodegenerative disorder characterized by the expansion of CAG repeats in the HTT gene. This...
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Tolerability of N-chlorotaurine in comparison with routinely used antiseptics: an in vitro study on chondrocytes
BackgroundCurrently, povidone-iodine (PVP-I) and hydrogen peroxide (H 2 O 2 ) are frequently used antiseptics in joint infections, but the cytotoxic...
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Unraveling the mechanistic interplay of mediators orchestrating the neuroprotective potential of harmine
Neurodegenerative diseases (NDDs) encompass a range of conditions characterized by the specific dysfunction and continual decline of neurons, glial...
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Role of Neutrophils as Therapeutic Targets in Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a major health problem. It is one of the most common types of stroke and results in mortality in approximately half...
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Dietary supplements may boost memory, but more evidence is required
Over the counter dietary supplements are a massive and growing market; however, there are few regulations or safeguards/protections for ensuring...
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Phytochemical and pharmacological properties of the genus Tamarix: a comprehensive review
The genus Tamarix in the Tamaricaceae family consists of more than 100 species of halophyte plants worldwide that are mainly used to improve...
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Nanoformulation of dasatinib cannot overcome therapy resistance of pancreatic cancer cells with low LYN kinase expression
BackgroundPancreatic ductal adenocarcinoma (PDAC) is one of the most difficult to treat tumors. The Src (sarcoma) inhibitor dasatinib (DASA) has...
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Potential of natural products in inflammation: biological activities, structure–activity relationships, and mechanistic targets
A balance between the development and suppression of inflammation can always be found in the body. When this balance is disturbed, a strong...
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Simultaneous Global Drug Development and Multiregional Clinical Trials (MRCT): 5 Years After Implementation of ICH E17 Guidelines
The ICH E17 guidelines (2014–2017) on Multiregional Clinical Trials (MRCT) was a joint effort by the regulators and industry to facilitate...
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Examining the Association Between DCT Solutions Use and Participant Diversity in Clinical Trials
BackgroundWhereas anecdotal reports suggest that the use of decentralized clinical trial (DCT) solutions can improve participant diversity in...
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Continuous TNF-α exposure in mammary epithelial cells promotes cancer phenotype acquisition via EGFR/TNFR2 activation
Tumor necrosis factor alpha (TNF-α), an abundant inflammatory cytokine in the tumor microenvironment (TME), is linked to breast cancer growth and...
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A Method to Redesign and Simplify Schedules of Assessment and Quantify the Impacts. Applications to Merck Protocols
The growing complexity of biopharmaceutical sponsored trials has adverse impacts on increased burdens on participants, clinical sites, and sponsors,...
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Good Statistical Monitoring: A Flexible Open-Source Tool to Detect Risks in Clinical Trials
BackgroundRisk-based quality management is a regulatory-recommended approach to manage risk in a clinical trial. A key element of this strategy is to...
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MDPV (3,4-methylenedioxypyrovalerone) administered to mice during development of the central nervous system produces persistent learning and memory impairments
BackgroundSynthetic cathinones (SC) constitute the second most frequently abused class of new psychoactive substances. They serve as an alternative...
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Regulatory Framework for Drug-Device Combination Products in the United States, Europe, and Korea
Combination products (CPs) combine two or more product types such as drugs, devices, and/or biological products for increased safety and clinical...
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Cyclosporin A Enhance the Cytotoxicity of Immunotoxin to the HER-2-Overexpressing SK-OV-3 Cells: A Prospective Study
This study explores the synergistic effect of T-CUS 245C combined with cyclosporin A, and its possible mechanism. T-CUS 245C is an immunotoxin...
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Polypogon monspeliensis Hepatoprotective Attributes: UHPLC/QTOF-MS/MS Metabolite Profiling and In Vitro and In Silico Studies
Polypogon monspeliensis (L.) Desf. is an annual monocot weed belonging to Poaceae family, with reported folkloric medicinal uses. In this work, the...
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Preventive Effects of Bioabsorbable Anti-Adhesion Barriers on Bowel Obstruction After Colectomy in Colon Cancer Patients: A Retrospective Cohort Study Using an Insurance Claims Database
PurposePostoperative adhesions can be prevented by the use of bioabsorbable anti-adhesion barriers. Although the occurrence of postoperative bowel...
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Challenges and Lessons Learned in Autologous Chimeric Antigen Receptor T-Cell Therapy Development from a Statistical Perspective
Chimeric antigen receptor (CAR) T-cell therapy is a human gene therapy product where T cells from a patient are genetically modified to enable them...
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Review of the Modern Market of Reagents for the Detection of Bacterial Endotoxins in Drugs
A comparative study of reagents obtained from hemolymph of Atlantic and Asian horseshoe crabs proved the reliability of bacterial endotoxin...
