Search
Search Results
-
Presynaptic antiseizure medications - basic mechanisms and clues for their rational combinations
Among clinically highly efficient antiseizure medications (ASMs) there are modifiers of the presynaptic release machinery. Of them, levetiracetam and...
-
Spectrophotometric Determination of Sodium Prodronate in Tablets for Osteoporosis Treatment
A spectrophotometric method for determining sodium prodronate in tablets by measuring the absorption at 237 ± 2 nm of a Cu(II)—prodronate complex in...
-
Synthesis, Antimicrobial and In Silico EGFR Inhibitory Activity Evaluation of Sulfonylamino Pyrrolidine Derivatives
A series of novel sulfonylamino pyrrolidine derivatives were synthesized, characterized and evaluated for their antimicrobial activity. All compounds...
-
Arsenic trioxide: applications, mechanisms of action, toxicity and rescue strategies to date
Arsenical medicine has obtained its status in traditional Chinese medicine for more than 2,000 years. In the 1970s, arsenic trioxide was identified...
-
Chromone Alkaloids: Structural Features, Distribution in Nature, and Biological Activity
Structural data of chromone alkaloids and antibiotics related to them that were isolated from natural sources up to 2017 are systematized in this...
-
Synthesis and Cytostatic Activity of New Mepregenol 17-Acetate Derivatives with Respect to Hela Cancer Cell Culture
New mepregenol 17-acetate derivatives with potential cytotoxicity were synthesized. Mepregenol 17-acetate 3-acrylate ( III ) was shown to exhibit...
-
The role of brain gaseous neurotransmitters in anxiety
Although anxiety is perhaps one of the most significant current medical and social problems, the neurochemical mechanistic background of this common...
-
The Search for Pharmacologically Active Compounds Among the 2-Dialkylaminobenzimidazoles
Heating of substituted benzimidazole-2-sulfonic acids in the presence of excess quantities of secondary amines was used to synthesize...
-
Synthesis, antitumor, antibacterial and urease inhibitory evaluation of new piperazinyl N-4 carbamoyl functionalized ciprofloxacin derivatives
BackgroundQuinolones are well known antibacterial chemotherapeutics. Furthermore, they were reported for other activities such as anticancer and...
-
Purification of Alkaloids by Countercurrent Chromatography
Alkaloids are nitrogen-containing compounds of the secondary metabolism of plants and microorganisms, which can also be found in animals, insects,...
-
Synthesis and Antitumor and Antibacterial Activity of Novel Dihydronaphthaline and Dihydrobenzo[H]Quinazoline Derivatives
A method for the synthesis of 1-amino-3,3-dimethyl-3,4-dihydronaphthaline-2-carbonitrile (β-aminonitrile) was developed and used to synthesize Schiff...
-
Synthesis and Analgesic and Anti-Inflammatory Activities of (3,3-Dipropyl-6,7-Dimethoxy-3,4-Dihydroisoquinolin-1(2H)-Ylidene)-Acetamide Hydrochlorides
Cyclocondensation of 4-(3,4-dimethoxybenzyl)heptan-4-ol with N-substituted cyanoacetamide was used to synthesize...
-
Anatomical characterization and LC-MS profiling of Adenophora roots from Korea
“Sasam
-
Synthesis and Pharmacological Activity of Ethyl-2-Amino-1-Benzamido-4-Oxo-5-(2-Oxo-2-Arylethylidene)Pyrrolidine-3-Carboxylates
Ethyl-2-amino-1-benzamido-4-oxo-5-(2-oxo-2-arylethylidene)pyrrolidine-3-carboxylates ( IIa - g ) were synthesized via recyclization of...
-
A novel isoquinoline derivative exhibits anti-inflammatory properties and improves the outcomes of endotoxemia
Background : Sepsis initiates an inflammatory response that causes widespread injury, and candidates for related myocardial depressant factors include...
-
Synthesis and Neurotropic Activity of 4-Phenylpyridine-3-Carboxylic Acid and 3-Hydroxy-4-Phenylthieno[2,3-b]-Pyridine Derivatives
Aseries of pyridine-3-carboxylic acid derivatives were synthesized via recyclization of a thiopyran ring using cyclic secondary amines and then...
-
Isoxazolidine Derivatives of Lappaconitine and Talatisamine
Isoxazolidine derivatives of lappaconitine and talatisamine were prepared by [3 + 2]-cycloaddition of lappaconitine and talatisamine nitrones to...
-
Effect of lacosamide on ethanol induced conditioned place preference and withdrawal associated behavior in mice: Possible contribution of hippocampal CRMP-2
BackgroundExcessive consumption of ethanol is known to activate the mTORC1 pathway and to enhance the Collapsin Response Mediator Protein-2 (CRMP-2)...
-
Novel compounds targeting InhA for TB therapy
Tuberculosis (TB) is described as lethal disease in the world. Resistant to TB drugs is the main reason to have unfavourable outcomes in the...
-
Lipase-Catalysed Addition of Pyrrolidine to Chalcone and Benzylidene Malonate Derivatives
The porcine pancreas lipase (PPL) type II catalyzes the aminolysis of benzylidene malonates by regiospecific amidation of substrates and afforded the...
