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Therapeutic Antidiabetic and Antioxidative Synergism of Zn(II)-Syringic Acid Complexation
Zinc(II) and syringic acid are natural supplements with medicinal attributes. The antidiabetic and antioxidative synergism between zinc(II) and...
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Hygrophila auriculata Improves Insulin Resistance by Reducing Oxidative Stress, Membrane Stabilization and Increasing Hepatic Heat Shock Protein 70 (Hsp70) Expression
The present study aimed to evaluate the effect of the methanolic extract of Hygrophila auriculata (Schumach.) Heine, Acanthaceae, in obesity-induced...
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Biological Activity of the Supramolecular Complex of Glycyrrhizic and Salicylic Acids
Supramolecular complexes of glycyrrhizic acid (GA) and salicylic acid (SA) in various mole ratios of 1:1, 2:1, 4:1, and 8:1 were prepared for the...
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The effect of selected aminoglycoside antibiotics on human serum albumin antioxidant activity: a spectroscopic and calorimetric comparative study
BackgroundHuman serum albumin (HSA) is a valuable component of non-enzymatic and endogenous antioxidant mechanisms. The antioxidant activity of HSA...
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Evaluation of the Pharmacotherapeutic Efficacy of Cycloartane Glycosides in Comparison to Lovastatin in Rabbits with Experimental Atherosclerosis
The cycloartane glycosides cyclocarposide and cyclosieversioside F prevent an increase in the blood serum contents of cholesterol, triglycerides, and...
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Evaluation of nano-curcumin against inhaled paraquat-induced lung injury in rats
BackgroundAcute lung injury (ALI) remains a significant source of morbidity and mortality in critically ill patients and currently there is no...
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Inhibition of autophagy with chloroquine dysregulates mitochondrial quality control and energetics in adipocytes
Autophagy is a complex degradation pathway through which damaged or dysfunctional proteins and organelles are removed. Its pharmacological modulators...
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Synthesis and Biological Evaluation of Arctigenin-Dipeptide Derivatives as Potential Anti-Fatigue Agents
Fatigue is a physiological phenomenon experienced by the human body when it undergoes prolonged physical and mental exertion, which can have...
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2-Mercaptoethanol protects against DNA double-strand breaks after kidney ischemia and reperfusion injury through GPX4 upregulation
BackgroundKidney ischemia reperfusion injury (IRI) is characterized by tubular cell death. DNA double-strand breaks is one of the major sources of...
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Cardiotoxicity linked to anticancer agents and cardioprotective strategy
Chemotherapy is a main treatment for cancer, and it benefits patients by controlling cancer relapse and metastasis, thereby leading to an increase in...
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Neuroprotective Effect of Lutein in Scopolamine-Induced Alzheimer’s Disease in Mice and Zebrafish
Lutein, a dietary antioxidant, can be a potent treatment for Alzheimer’s disease. In this study, the neuroprotective effect of lutein against...
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Madhuca indica: A Review on the Phytochemical and Pharmacological Aspects
Madhuca indica J.F. Gmel. (family: Sapotaceae), commonly known as Mahua in Indian dialects, occupies the importance as one of the fuel-efficient,...
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Daidzein Attenuates Ovariectomy-Induced Cognitive Deficits by Improving Cortical Endothelial Function in Rats
There have been reports of decreased vascular activity in memory-sensitive brain areas, which is thought to be a different approach to managing...
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Liquiritin Relieves Oxygen-Glucose Reperfusion-Induced Neuronal Injury via Inhibition of the p38MAPK/NF-κB Signaling Pathway
In traditional Chinese medicine, liquiritin, an active component of Glycyrrhiza uralensis Fisch . , Fabaceae, has several pharmacological effects such...
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Camellia Oil Ameliorates the Intestinal Inflammation Stress in Female Drosophila melanogaster
Camellia oil, known as “Eastern olive oil,” is one of the most widely consumed edible oils in Asia and a key functional food for pregnant or...
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Low Molecular Weight NGF Mimetic Enhances the Overall Plasma Antioxidant Capacity in Rats with Streptozotocin-Induced Diabetes
Results from studies of the antidiabetic and antihyperglycemic activity of a low-molecular-weight NGF mimetic, compound GR-2 [bis-( N -monosuccinyl- L -glutamyl-...
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Fenofibrate ameliorates testicular damage in rats with streptozotocin-induced type 1 diabetes: role of HO-1 and p38 MAPK
BackgroundSince diabetes mellitus type-1 (DM-1) induces testicular oxidative and inflammatory damage with finally an ultimate male infertility, and...
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Carnosic Acid Protects Against Myocardial Infarction by Controlling Oxidative Stress and Inflammation in Rats
Carnosic acid possesses antioxidant and anti-inflammatory effects. Early evidence indicates that this phenolic diterpenoid protects the heart against...
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Antiproliferative Activity of Extracts Containing Flavonoids from In Vitro Callus Cultures of Astragalus onobrychis
Astragalus onobrychis L., Fabaceae, is a perennial herbaceous plant with a strong taproot and reaches a height of 10–60 cm. The stems have a woody...
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Co-Administration of Polyamines with Rutin and Metformin Ameliorates Streptozotocin-Induced Diabetes: Possible Involvement of Antioxidants, Inflammatory Cytokines, and Biochemical Paradigms
The present investigation was undertaken to study the role of polyamines and rutin in combination with metformin in the streptozotocin-induced...
