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Effects of chronic delta-opioid receptor agonist on the excitability of hippocampal glutamate and brainstem monoamine neurons, anxiety, locomotion, and habituation in rats
BackgroundShort-term treatment with non-peptide agonists of delta-opioid receptors, such as agonist SNC80, induced behavioral effects in rodents,...
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Delta-opioid receptor-mediated modulation of excitability of individual hippocampal neurons: mechanisms involved
BackgroundDelta-opioid receptor (DOR)-mediated modulation of hippocampal neural networks is involved in emotions, cognition, and in pathophysiology...
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Guanfacine inhibits interictal epileptiform events and sodium currents in prefrontal cortex pyramidal neurons
BackgroundGuanfacine (an alpha-2A receptor agonist) is a commonly used drug with recognized efficacy in the treatment of attention deficit...
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Pharmacology and adverse effects of new psychoactive substances: synthetic cannabinoid receptor agonists
Over the last decade, new psychoactive substances (NPS) have continuously been the focus of the international society since their emergence on the...
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Formyl peptide receptor 2, as an important target for ligands triggering the inflammatory response regulation: a link to brain pathology
Formyl peptide receptors (FPRs) belong to the family of seven-transmembrane G protein-coupled receptors. Among them, FPR2 is a low affinity receptor...
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The effects of a competitive antagonist on GABA-evoked currents in the presence of sedative-hypnotic agents
BackgroundMany sedative-hypnotic agents are thought to act by positively modulating γ-aminobutyric acid type A (GABA A ) receptors. However, for many...
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Involvement of the ventral, but not dorsal, hippocampus in anxiety-like behaviors in mice exposed to the elevated plus maze: participation of CRF1 receptor and PKA pathway
BackgroundThe hippocampus is a limbic structure involved in anxiety-like behaviors. We aimed to evaluate the role of the dorsal (DH) and ventral (VH)...
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Influence of G protein-biased agonists of μ-opioid receptor on addiction-related behaviors
Opioid analgesics remain a gold standard for the treatment of moderate to severe pain. However, their clinical utility is seriously limited by a...
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The possible place for psychedelics in pharmacotherapy of mental disorders
Since its emergence in the 1960s, the serotonergic theory of depression bore fruit in the discovery of a plethora of antidepressant drugs affecting...
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Acute cocaine treatment enhances the antagonistic allosteric adenosine A2A-dopamine D2 receptor–receptor interactions in rat dorsal striatum without increasing significantly extracellular dopamine levels
BackgroundAntagonistic adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) receptor–receptor interactions have previously been demonstrated in...
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A New Piperidine Derivative with Antiserotonin Anti-Migraine Activity and Its Combination with Picamilon
A new serotonin antagonist with anti-migraine activity, 2,3,4-trimethoxy- N -(2,2,6,6-tetramethylpiperidin-4-ylidene)benzohydrazide hydrochloride...
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Inhibitory effect of intrathecally administered AM404, an endocannabinoid reuptake inhibitor, on neuropathic pain in a rat chronic constriction injury model
BackgroundThe endocannabinoid system modulates a wide variety of pain conditions. Systemically administered AM404, an endocannabinoid reuptake...
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Peroxisome proliferator-activated receptor gamma: a novel therapeutic target for cognitive impairment and mood disorders that functions via the regulation of adult neurogenesis
The proliferation, differentiation, and migration of neural precursor cells occur not only during embryonic development but also within distinct...
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Synthesis and Pharmacological Properties of N-Decyltropine (IEM-1556) as Compared to Selective Nicotinic Receptor Antagonist Tert-Butyldecylammonium (IEM-1678)
The property profile of N -decyltropine (IEM-1556) has significant advantages over that of its prototype, the selective nicotinic receptor antagonist tert...
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Insights into a possible role of glucagon-like peptide-1 receptor agonists in the treatment of depression
Depression is a highly prevalent mood disorder and one of the major health concerns in modern society. Moreover, it is characterized by a high...
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Avacopan in granulomatosis with polyangiitis and microscopic polyangiitis: a profile of its use
Avacopan (TAVNEOS ® ), a first-in-class, small molecule, selective antagonist of the complement fragment 5a receptor (C5aR), is an effective and...
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MiR-340 regulates the growth and metabolism of renal cell carcinoma cells by targeting frizzled class receptor 3
MicroRNA(miR)-340 is known as a multifunctional miRNA related to various types of cancer while its role in renal cell carcinoma (RCC) remains to be...
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Dication Molecules as Tools for Studying Actylcholine and Glutamate Receptors (Review)
The review covers the pharmacochemical study of two receptor types, the neuronal nicotinate receptor and the glutamate receptor. The...
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Thyroid hormones reduce nicotinic receptor mediated currents in SH-SY5Y neuroblastoma cells
BackgroundThyroid hormones (THs) are crucial for maturation and functioning of mammalian CNS. THs “classical” signaling involves nuclear receptors...
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The role of bidirectional communication between the adipokines and the endogenous opioid system in an experimental mouse model of colitis-associated colorectal cancer
BackgroundColorectal cancer (CRC) is one of the leading causes of death globally. Multiple factors may contribute to the pathogenesis of CRC,...
