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1. mRNA COVID-19 vaccines are well tolerated and myopericarditis is a rare adverse event following immunisation

   mRNA vaccines are considered to be important tools for the management of the COVID-19 pandemic. Although mRNA COVID-19 vaccines are well tolerated in...

   Caroline Fenton, Arnold Lee in Drugs & Therapy Perspectives

   Article 15 November 2022

2. Von in vitro zu in vivo: Optimierung von ADME-Tox-Eigenschaften

   Die Wechselwirkung einer Substanz mit der Bindestelle eines therapeutisch relevanten biologischen Makromoleküls ist die entscheidende Grundlage für...

   Gerhard Klebe in Wirkstoffdesign

   Chapter 2023
   

3. Preclinical models of treatment-resistant depression: challenges and perspectives

   Treatment-resistant depression (TRD) is a subgroup of major depressive disorder in which the use of classical antidepressant treatments fails to...

   Magdalena Kolasa, Agata Faron-Górecka in Pharmacological Reports

   Article Open access 26 October 2023
   

4. Central nervous system disorders after use of dolutegravir: evidence from preclinical and clinical studies

   The evaluation of dolutegravir based on available preclinical and clinical studies reveals a risk of central nervous system (CNS) disorders...

   Alicja Jakimiuk, Agnieszka Piechal, ... Dagmara Mirowska-Guzel in Pharmacological Reports

   Article Open access 21 August 2023
   

5. Consider clinically relevant drug interactions when prescribing edoxaban

   Edoxaban, a factor Xa inhibitor, is a direct oral anticoagulant (DOAC). DOACs may have a lower incidence of drug-drug interactions (DDIs) than...

   Esther S. Kim, Young-A Heo in Drugs & Therapy Perspectives

   Article 16 January 2021

6. Voclosporin in lupus nephritis: a profile of its use

   Voclosporin (Lupkynis™), a novel calcineurin inhibitor, is approved in the USA as an add-on to background immunosuppressive therapy in adults with...

   Esther S. Kim, Susan J. Keam in Drugs & Therapy Perspectives

   Article 17 January 2022

7. Effect of polyphenols against complications of COVID-19: current evidence and potential efficacy

   The COVID-19 pandemic that started in 2019 and resulted in significant morbidity and mortality continues to be a significant global health challenge,...

   Mahdi Vajdi, Arash Karimi, ... Amirhossein Sahebkar in Pharmacological Reports

   Article 18 March 2024
   

8. Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells

   Background

   Multifunctional thiosemicarbazones (TSCs) able to bind sigma receptors and chelate metals are considered as a promising avenue for the...

   Joanna Kopecka, Alessandra Barbanente, ... Carmen Abate in Pharmacological Reports

   Article Open access 05 October 2023
   

9. A Molecular Insight into Significance of Functional Foods in Better Management of Rheumatoid Arthritis

   Rheumatoid arthritis is a systemic, autoimmune disorder of complex etiology, characterized by chronic inflammation of joints with severe pain and...

   Aastha Guleria, Akhil Kamboj, ... Archana Bhatnagar in Revista Brasileira de Farmacognosia

   Article 01 June 2022
   

10. Biodistribution of ¹⁷⁷Lu-DOTA-PSMA in Mice with Prostate Carcinoma 22Rv1

    Prostate-specific membrane antigen (PSMA) is overexpressed in prostate cancer and is a well-studied target for therapy of this pathology with...

    V. K. Tishchenko, V. M. Petriev, ... A. D. Kaprin in Pharmaceutical Chemistry Journal

    Article 09 May 2023
    

11. Inhibitors of Nitric Oxide Production from the Seeds of Myristica fragrans: Experimental and Computational Results

    This study focuses on the extraction of eleven compounds from Myristica fragrans Houtt., Miristicaceae, seeds, guided by their anti-inflammatory...

    Dao Cuong To, Phi Hung Nguyen, ... Hong Khuyen Thi Pham in Revista Brasileira de Farmacognosia

    Article 23 May 2024
    

12. Glycoalkaloids of Plants in the Family Solanaceae (Nightshade) as Potential Drugs

    Worldwide interest in medicinal plants and related drugs is growing because of the increased spectrum of new synthetic drugs. In this context,...

    T. O. Ostreikova, O. V. Kalinkina, ... I. V. Chernykh in Pharmaceutical Chemistry Journal

    Article 18 October 2022
    

13. L-proline transporter inhibitor (LQFM215) promotes neuroprotection in ischemic stroke

    Background

    L-proline transporter (PROT/SLC6A7) is closely associated with glutamatergic neurotransmission, where L-proline modulates the NMDA receptor...

    Gustavo Almeida Carvalho, Raphaela Almeida Chiareli, ... Mauro Cunha Xavier Pinto in Pharmacological Reports

    Article 31 January 2023
    

14. Effect of Bumetanide Administration on the Pharmacoresistant Seizure to Lamotrigine in Electrical Amygdala Kindled Rats

    In recent decades, 30 – 40 percent of epilepsy patients did not get relief from seizures by antiepileptic medications. In the present study, the...

    Reyhaneh Kheiri, Abbas Kebriaeezadeh, ... Marzieh Khodadadi in Pharmaceutical Chemistry Journal

    Article 19 June 2023
    

15. Polypogon monspeliensis Hepatoprotective Attributes: UHPLC/QTOF-MS/MS Metabolite Profiling and In Vitro and In Silico Studies

    Polypogon monspeliensis (L.) Desf. is an annual monocot weed belonging to Poaceae family, with reported folkloric medicinal uses. In this work, the...

    Hatem S. Abbass, Mostafa M. Hegazy, ... Atef A. El-Hela in Revista Brasileira de Farmacognosia

    Article 07 May 2024
    

16. Berberine and its derivatives represent as the promising therapeutic agents for inflammatory disorders

    Berberine, with the skeleton of quaternary ammonium, has been considered as the well-defined natural product in treating multiple diseases, including...

    Qiukai Lu, Yifan Fu, Heng Li in Pharmacological Reports

    Article 27 January 2022
    

17. Isoacteoside Protects Against Sepsis-Induced Acute Lung Injury by Regulating the SIRT1/Nrf2/NF-κB/NLRP3 Signaling Pathways

    Sepsis-related acute lung injury is a severe inflammatory pulmonary disorder. Isoacteoside is a phenylethanoid derived from Monochasma savatieri ...

    Zhong Li, Gangming Hu in Revista Brasileira de Farmacognosia

    Article 17 November 2022
    

18. Role of Neutrophils as Therapeutic Targets in Intracerebral Hemorrhage

    Intracerebral hemorrhage (ICH) is a major health problem. It is one of the most common types of stroke and results in mortality in approximately half...

    Alper Fatih Ardic, Nurittin Ardic in Therapeutic Innovation & Regulatory Science

    Article 16 May 2024
    

19. Inhibition by Hypericin of Tongue Squamous Carcinoma Cell Proliferation and Treatment of Resistance in Dental Pulp Stem Cells

    Tongue cancer is a malignancy affecting the head and neck region that has exhibited an increased incidence in recent decades, primarily attributed to...

    Fateme Tondro, Sahba Shahbazi, ... Mohammad Amin Javidi in Revista Brasileira de Farmacognosia

    Article 02 March 2024
    

20. Investigation of the Anti-asthmatic Activity of Solidagenone, In Vitro Toxicity Versus In Silico Studies

    Solidagenone, a labdane diterpene isolated from inflorescences of Solidago chilensis Meyen, Asteraceae, was investigated for its anti-inflammatory...

    Deise Cristina Drummond Xavier Paes Lopes, Thais Morais de Brito, ... Eduardo Ricci Junior in Revista Brasileira de Farmacognosia

    Article 15 November 2023