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Antitumor Activity of Antiestrogen-Cytostatics and Their Binding Affinity with Estrogen Receptors
Compounds Ro-714, Ro-716, and Ro-728 containing an antiestrogenic steroid moiety associated with a bis-β-chloroethylamine group exhibit pronounced...
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Anti-hepatic Fibrosis Potential of Ailanthone, A Quassinoid Isolated from Ailanthus altissima
Ailanthone is an active ingredient isolated from Ailanthus altissima (Mill.) Swingle, Simaroubaceae, which is a traditional medicine widely used in...
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Unlocking the Potential of Brusatol as an Antitumoral Agent: Molecular Mechanisms and Therapeutic Benefits
Traditional Chinese medicine relies on brusatol to combat various diseases, including cancer. Considering the wide variety of natural substances and...
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Inhibition of Human CYP1A1/A2 by a Hydroalcoholic Extract and Its Neolignan Constituents from Piper rivinoides
Lignans and neolignans, commonly found in plants, are generally composed of two phenylpropane (C 6 -C 3 ) units with a marked diversity of molecular...
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Emodin Alleviates the Th17/Treg Imbalance by Targeting Myd88/NF-κB Signaling in Subacute Thyroiditis
Subacute thyroiditis, an immune response of the thyroid gland, is associated with the imbalance of the Th17/Treg ratio. Emodin has been proven to...
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Synthesis, Cytotoxic Activity and Molecular Docking Studies of New Condensed Thieno[2,3-d]Pyrimidines as Antitumor Agents
A series of twenty molecules based on thienopyrimidine nucleus fused with 5-, 6-, and 7-membered lactam rings as well as triazole were synthesized...
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Design, Synthesis and Biological Evaluation of 7-Azaindole Analogues as Novel Antiproliferative Agent and Tyrosine Protein Kinase SRC Inhibitors
A new series of SRC inhibitors based on 7-azaindole core were designed, synthesized and evaluated for antiproliferative and antioxidant activities....
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Isoflavone-Rich Extract of Trifolium resupinatum: Anti-obesity Attributes with In Silico Investigation of Its Constituents
Trifolium resupinatum L., Fabaceae, aqueous methanol leaf extract was selected to mitigate some obesity-associated risk factors to validate the...
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Coumarin and 3,4-dihydroquinolinone derivatives: Synthesis, antidepressant activity, and molecular docking studies
Background : Coumarin and 3,4-dihydroquinolinone nuclei are two heterocyclic rings that are important and widely exploited for the development of...
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Synthesis, In Silico Analysis, Antibacterial, Radical Scavenging and Antidiabetic Activities of Certain Bis-Azetidinones and Bis-Thiazolidinones
A panel of 1,1-(phenylene)bis[3-chloro-4-(substituted phenyl)azetidin-2-ones] ( 4a-m ) and 3,3′-(1,4-phenylene)bis[2-(substituted...
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Anti-elastase, Anti-tyrosinase, and Anti-inflammatory Activities of Three Compounds Isolated from Psorospermum aurantiacum: In Silico and In Vitro Assays
The hexane fraction of Psorospermum aurantiacum Engl., Hypericaceae, was found to prevent photo aging in skin cells lines. Therefore, this research...
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In Vitro Cytotoxicity of Methano[1,2,4]Triazolo-[1,5-C][1,3,5]Benzoxadiazocine Derivatives and Their Effects on Nitrite and Prostaglandin E2 (PGE2) Levels
Biological activity of the Biginelli type heterocycles is extremely broad and provides a suitable platform for the discovery of potent small...
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Inhibitors of Nitric Oxide Production from the Seeds of Myristica fragrans: Experimental and Computational Results
This study focuses on the extraction of eleven compounds from Myristica fragrans Houtt., Miristicaceae, seeds, guided by their anti-inflammatory...
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Ameliorating effects of berberine on sepsis-associated lung inflammation induced by lipopolysaccharide: molecular mechanisms and preclinical evidence
As a life-threatening disorder, sepsis-associated lung injury is a dysregulated inflammatory response to microbial infection, characterized by the...
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Phytochemical Investigation of Egyptian Spinach Leaves, a Potential Source for Antileukemic Metabolites: In Vitro and In Silico Study
Spinacia oleracea L., Amaranthaceae, leaves cultivated in Egypt demonstrated a potential antileukemic activity against the chronic myeloid leukemia,...
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Molecular mechanism of ferulic acid and its derivatives in tumor progression
Cancer is a significant disease that poses a major threat to human health. The main therapeutic methods for cancer include traditional surgery,...
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Polypogon monspeliensis Hepatoprotective Attributes: UHPLC/QTOF-MS/MS Metabolite Profiling and In Vitro and In Silico Studies
Polypogon monspeliensis (L.) Desf. is an annual monocot weed belonging to Poaceae family, with reported folkloric medicinal uses. In this work, the...
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Sedative, Muscle Relaxant-Like Effects, and Molecular Docking Study of Compounds Isolated from Salvia leriifolia
Salvia leriifolia Benth., Lamiaceae, an endemic medicinal plant of the northern region of Iran, has been documented as sedative. It has been used in...
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Targeting Lipoxygenase Enzyme by Flavonoids from Tadehagi triquetrum: a Combined In Silico and In Vitro Approach
Tadehagi triquetrum (L.) H.Ohashi, Fabaceae, is a flowering sub-shrub of the legume family. The present research focused on the in silico studies of...
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Psoralen Ameliorates Acetaminophen-Induced Acute Liver Injury by Inhibiting the Enzymatic Activity of CYP2E1
Excessive administration of the antipyretic and analgesic drug acetaminophen can cause acute liver injury. The mechanism is that a large amount of N -acetyl-...
