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Therapeutic potential of melatonin in targeting molecular pathways of organ fibrosis
Fibrosis, the excessive deposition of fibrous connective tissue in an organ in response to injury, is a pathological condition affecting many...
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Suppression of nitric oxide synthase aggravates non-alcoholic steatohepatitis and atherosclerosis in SHRSP5/Dmcr rat via acceleration of abnormal lipid metabolism
BackgroundNon-alcoholic steatohepatitis (NASH) is a progressive subtype of non-alcoholic fatty liver disease (NAFLD) that is closely related to...
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Tyrosine Kinase Inhibitor Si409 Has In Vitro and In Vivo Anti-Tumor Activity Against Diffuse Large B-Cell Lymphoma
The abnormal activation of Src family kinases (SFKs) due to deregulation of the B-cell receptor (BCR) signalling pathway provides a promising target...
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Synthetic lipoproteins based on apolipoprotein E coupled to fullerenol have anti-atherosclerotic properties
BackgroundApolipoprotein E (apoE) is an anti-atherosclerotic protein associated with almost all plasma lipoproteins. Fullerenol (Full-OH) contains...
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Co-Administration of Polyamines with Rutin and Metformin Ameliorates Streptozotocin-Induced Diabetes: Possible Involvement of Antioxidants, Inflammatory Cytokines, and Biochemical Paradigms
The present investigation was undertaken to study the role of polyamines and rutin in combination with metformin in the streptozotocin-induced...
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Possible Mechanisms for the Prevention of Anxiety and Depressive-Like Behavior in a Chronic Mild Stress Mouse Model by the Thai Herbal Medicine with Nelumbo nucifera, Centella asiatica, and Piper nigrum
The development of anxiety and depression due to chronic exposure to stress is an emerging health problem. NCP formula is a combination of three...
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Detection, Monitoring, and Mitigation of Drug-Induced Nephrotoxicity: A Pragmatic Approach
The kidneys play a pivotal role in elimination of most drugs; therefore, a comprehensive understanding of renal physiology and pathology is important...
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New therapeutic strategies in nonalcoholic fatty liver disease: a focus on promising drugs for nonalcoholic steatohepatitis
The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Globally, it is currently the most common liver disease and is...
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Ginsenoside Rg5 as an anticancer drug: a comprehensive review on mechanisms, structure–activity relationship, and prospects for clinical advancement
Cancer remains one of the leading causes of death in the world. Despite the considerable success of conventional treatment strategies, the incidence...
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Therapeutic action against chronic cholestatic liver injury by low-dose fenofibrate involves anti-chemotaxis via JNK–AP1–CCL2/CXCL2 signaling
BackgroundFenofibrate was reported to be beneficial for cholestasis in combination with ursodeoxycholic acid. However, its therapeutic action as...
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Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies
Sarcopenia is a multifactorial condition characterized by loss of muscle mass. It poses significant health risks in older adults worldwide. Both...
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Protective effect of kinsenoside on acute alcohol-induced liver injury in mice
Anoectochilus roxburghii (Wall.) Lindl., Orchidaceae, is a Chinese medicinal plant which can be effective for some diseases such as hepatitis,...
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Molecular insights into the role of mitochondria in non-alcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common cause of fatal liver diseases such as cirrhosis, liver cancer, and...
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Advances in the anti-tumor mechanisms of saikosaponin D
Saikosaponin D, a saponin compound, is extracted from Bupleurum and is a principal active component of the plant. It boasts a variety of...
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Treating paediatric Crohn’s disease is challenging but new treatments hold promise
Paediatric Crohn’s disease is associated with a high disease burden and greater requirement for immunosuppression compared with adult-onset disease....
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Therapeutic implication of Sonic Hedgehog as a potential modulator in ischemic injury
Sonic Hedgehog (SHh) is a homology protein that is involved in the modeling and development of embryonic tissues. As SHh plays both protective and...
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Physicochemical Characterization and Biological Evaluation of Agaricus subrufescens Polysaccharides in Human Blood Cells
The present work aimed to isolate and characterize the polysaccharides from Agaricus subrufescens Peck (1893), Agaricaceae, and subsequently evaluate...
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Vitamin K: a Potential Neuroprotective Agent
Neurodegeneration, a progressive disease due to the arrested development of atrophy and regression of neuron function, is the most common disorder...
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Novel method of measurement of in vitro drug uptake in OATP1B3 overexpressing cells in the presence of dextran
BackgroundIn predictions about hepatic clearance (CL H ), a number of studies explored the role of albumin and transporters in drug uptake by liver...
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Synthesis, in Silico and in Vitro Study on Phase I Metabolism of the Potent 5-Ht7/5-Ht1a/D2 Receptor Ligand: 4-Fluoron -(1-{2-[2-(Methylsulfanyl)- Phenoxy]Ethyl}Pyrrolidin-3-Yl) Benzene Sulfonamide
In the present study we analyze the synthesis as well as biotransformation pathways and metabolic stability of 4-fluoro- N ...
