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One-Pot Synthesis of 2nd Ruthenium Grubbs Catalyst for Preparation of One Stapled Peptide
2nd Grubbs catalyst was prepared using a new strategy for efficient preparation of a stapled peptide. The reaction was short and avoided the effect...
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A perspective on the applications of furin inhibitors for the treatment of SARS-CoV-2
Currently, the world is facing a pandemic of the new coronavirus SARS-CoV-2 that causes COVID-19. Identifying key targets in the viral infection...
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Physical-Chemical Characterizations of Synthetic Dual Niosomes for Antibacterial Delivery of Lysostaphin and LL-37
Non-ionic surfactant vesicles known as niosomes are synthetic vesicles with numerous pharmaceutical applications. In this study, a unique combination...
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Microneedle and Polymeric Films: Delivery of Proteins, Peptides and Nucleic Acids
In the last 20 years, protein, peptide and nucleic acid-based therapies have become the fastest growing sector in the pharmaceutical industry and...
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In Vivo Study to Explore the Antiarthritic Potential of Tiliroside on Complete Freund’s Adjuvant-Induced Rheumatoid Arthritis in Rats
The purpose of this research was to examine the pharmacological properties and potential mechanism of action of tiliroside in rheumatoid arthritis....
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Antiviral peptides against SARS-CoV-2: therapeutic targets, mechanistic antiviral activity, and efficient delivery
The global pandemic of COVID-19 is a serious public health concern. Over 625 million confirmed cases and more than 6 million deaths have been...
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Evolving Type 2 diabetes management focuses on clinical outcomes
Type 2 diabetes mellitus, defined by hyperglycaemia, is very common and carries long-term cardiovascular (CV) and renal risks. Management has evolved...
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Vosoritide in achondroplasia: a profile of its use
Subcutaneous vosoritide (Voxzogo ® ), a modified recombinant human C-type natriuretic peptide (CNP) analogue, is the first precision therapy approved...
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Elimination Half-Life of Short Peptide Drugs in Humans Extrapolated From Animal Pharmacokinetic Pharmacokinetic Studies
Results from an interspecies scaling study of the elimination half-lives of the anxiolytic GB-115 and the antipsychotic dilept in rats, rabbits, and...
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Death-associated protein kinase 1 phosphorylates MDM2 and inhibits its protein stability and function
Breast cancer is one of the major malignancies in women, and most related deaths are due to recurrence, drug resistance, and metastasis. The...
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Antipsychotic drug—aripiprazole against schizophrenia, its therapeutic and metabolic effects associated with gene polymorphisms
Second-generation antipsychotics are widely used for the treatment of schizophrenia. Aripiprazole (ARI) is classified as a third-generation...
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Educate patients with medication overuse headache, and intervene, when necessary
Medication overuse headache (MOH) most commonly affects people with migraine, particularly in patients who overuse medications intended for...
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Identification of Novel Peptides Targeting DNA Methyltransferase 1 (DNMT-1) for Breast Cancer Treatment
Epigenetic alteration shows an essential role in the process of breast cancer cell proliferation and propagation. DNA methyltransferase (DNMT) is...
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Effects of chronic delta-opioid receptor agonist on the excitability of hippocampal glutamate and brainstem monoamine neurons, anxiety, locomotion, and habituation in rats
BackgroundShort-term treatment with non-peptide agonists of delta-opioid receptors, such as agonist SNC80, induced behavioral effects in rodents,...
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Engineered fibrotic liver-targeted truncated transforming growth factor β receptor type II variant for superior anti-liver fibrosis therapy
Truncated transforming growth factor β receptor type II (tTβRII) is a promising anti-liver fibrotic candidate because it serves as a trap for binding...
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Aducanumab: a review of the first approved amyloid-targeting antibody for Alzheimer’s disease
Aducanumab is a human immunoglobulin G1 monoclonal antibody that binds to the linear epitope formed by amino acids 3–7 of the Aβ peptide, with a...
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Total Synthesis of Cyclic Lipodepsipeptide Ophiotine
The first total synthesis of the natural nematicidal cyclic lipodepsipeptide ophiotine via a convergent strategy that involved both solid-phase...
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Liganden für Kanäle, Poren und Transporter
Die Zelle ist die kleinste strukturelle und funktionale Einheit aller Lebewesen. Einzeller bestehen nur aus einer einzigen solchen Einheit. Bei...
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Synthesis and Infarction-Limiting Properties of Peptide Agonists of Opioid Receptors
Three structurally different peptide agonists of opioid receptors, i.e., gludalan, deltolei, and dalargin, were synthesized and assessed for...
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Liquid Crystals: Characteristics, Types of Phases and Applications in Drug Delivery
The present review article relates to some theoretical aspects of liquid crystals, particularly types and phases of liquid crystals. In recent years...
