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Method Development for Quantitative Determination of Ormustine in Biological Fluids by High Performance Liquid Chromatography with Mass-Spectrometric Detection
An HPLC method over a Kromasil C18 reversed-phase column with mass spectrometric detection and EtOH:NH 4 OAc (10:90) mobile phase was developed for...
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Turbo-extraction of glycosides from Stevia rebaudiana using a fractional factorial design
Stevia rebaudiana (Bertoni) Bertoni, Asteraceae, leaf extract has recently called the attention of food industry as a proposal for natural sweetener....
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Brown Alga Metabolites – Inhibitors of Marine Organism Fucoidan Hydrolases
Fucoidan hydrolase inhibitors were discovered for the first time. Metabolites in the aqueous EtOH extract of Fucus evanescens inhibited specifically...
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Pilot and Industrial Absorption-Chromatographic and Membrane Technologies for Isolation and Purification of Plant- and Animal-Based Active Pharmaceutical Ingredients
Development and implementation of pilot and industrial absorption-chromatographic and membrane technologies for the isolation and purification of...
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Determination of S-(−)-lansoprazole in dexlansoprazole preparation by capillary zone electrophoresis
AbstractCapillary zone electrophoresis was successfully applied to the enantiomeric purity determination of dexlansoprazole using sulfobutyl...
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Combination of a chemopreventive agent and paclitaxel in CD44-targeted hybrid nanoparticles for breast cancer treatment
The CD44 receptor, which is upregulated in many cancer cells, provides a selective cellular surface for targeted drug delivery systems. We developed...
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Pharmacokinetics of Quercetin and Other Flavonols Studied by Liquid Chromatography and LC-MS (a Review)
Modern analytical methods used to study the pharmacokinetics of quercetin and other flavonols, i.e., biologically active compounds that exhibit...
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Analytical Methods for the Determination of Atypical Neuroleptics (Review)
General analytical trends and approaches to quantitative determination of atypical neuroleptics (antipsychotics) in biological matrices were...
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Qualification and application of a liquid chromatography–tandem mass spectrometric method for the determination of human Aβ1-40 and Aβ1-42 peptides in transgenic mouse plasma using micro-elution solid phase extraction
A liquid chromatographic–tandem mass spectrometric (LC–MS/MS) method was developed and applied for the determination of human Aβ1-40 and Aβ1-42...
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Parenteral
This chapter gives an overview of parenteral dosage forms and the rational for their use. Parenterals are sterile preparations that are injected...
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Protein Binding
Incorporation of pharmacokinetic information of anticancer drugs into routine patient care can contribute to drug dosage individualization and...
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Preparation of Neomytilan, a Bioglycan from the Mussel Crenomytilus grayanus, and its Immunostimulating Activity
Bioglycans isolated from the Far-East mussel Crenomytilus grayanus were compared analytically. It was found that neomytilan, a bioglycan with reduced...
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Binding of new aminopropan-2-ol compounds to bovine serum albumin, α1-acid glycoprotein and rat serum using equilibrium dialysis and LC/MS/MS
BackgroundThe binding of three new aminopropan-2-ol compounds briefly called 2F109, ANBL and TWo8 with potential cardiovascular activity to bovine...
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Considerations in Manufacturing Process Development for Antibody-Based Therapeutics
Antibody-based therapeutics are a rapidly growing sector of new pharmaceutical drug candidates. As the therapeutic utility of monoclonal antibodies...
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Application, chemical composition, and standardization of nettle raw material and related drugs (Review)
Literature on the application, chemical composition, and standardization of nettle ( Urtica ) raw material and related medicinal plant preparations is...
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Ethosomes, binary ethosomes and transfersomes of terbinafine hydrochloride: A comparative study
The aim of this study was to compare the skin permeation of ethosomes, binary ethosomes and transfersomes of Terbinafine Hydrochloride (TH) under...
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Extraction, composition and the antioxidant and anticomplement activities of high molecular weight fractions from the leaves of Symphytum asperum and S. caucasicum
High molecular weight fractions (> 1000 kDal) from the leaves of Symphytum asperum and S. caucasicum had anticomplement activity, were able to...
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Summary of DIA Workshop: Comparability Challenges: Regulatory and Scientific Issues in the Assessment of Biopharmaceuticals
On February 3–4, 2009, a DIA Workshop was held to review and discuss comparability challenges and issues for biotechnology-derived pharmaceuticals....
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Pharmacokinetics of magnolin in rats
This study was first conducted to characterize the intravenous and oral pharmacokinetics of magnolin, a major pharmacologically active ingredient of Ma...