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Use of glucocorticoids and azithromycin in the therapy of COVID-19
In December 2019, a new variant coronavirus, SARS-CoV-2, emerged in China, which was initially described as a pneumonia of an unknown agent. The new...
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Phase I and phase II metabolite identification of rutaecarpine in freshly isolated hepatocytes from male Sprague–Dawley rats
Rutaecarpine, an alkaloid originally isolated from Evodia rutaecarpa , has been used for the treatment of gastrointestinal disorders in Asia. In the...
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Relationship between plasma exposure of zolpidem and CYP2D6 genotype in healthy Korean subjects
Zolpidem, a widely prescribed hypnotic agent, is extensively metabolized by cytochrome P450 (CYP) 3A4, and CYP2C9, CYP1A2 and CYP2D6 are also...
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Coronavirus Disease 2019 and Herbal Therapy: Pertinent Issues Relating to Toxicity and Standardization of Phytopharmaceuticals
Coronavirus disease 2019 (COVID-19) is a virulent viral disease that has now become a public health emergency of global significance and still...
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Cryptotanshinone ameliorates placental oxidative stress and inflammation in mice with gestational diabetes mellitus
Gestational diabetes mellitus (GDM) is a conditional diabetes which is defined as any degree of glucose intolerance or high blood glucose levels...
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Drug repurposing approach to fight COVID-19
Currently, there are no treatment options available for the deadly contagious disease, coronavirus disease 2019 (COVID-19). Drug repurposing is a...
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Phytochemical and pharmacological properties of Myristica fragrans Houtt.: an updated review
Myristica fragrans Houtt. (Myristicaceae), an aromatic evergreen tree, is well known as a commercial source of mace (aril) and nutmeg (seed), which...
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Development of a column-switching LC-MS/MS method of tramadol and its metabolites in hair and application to a pharmacogenetic study
Hair is a valuable specimen for monitoring long-term drug use. Tramadol is an effective opioid analgesic but is associated with risks such as drug...
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Ortho-vanillin nanoparticle-doped glucan microspheres exacerbate the anti-arthritic effects of methotrexate in adjuvant-induced arthritis in rats
BackgroundMethotrexate (MTX) commonly used in rheumatoid arthritis (RA) has severe adverse effects. Ortho-vanillin, an inhibitor of Toll-like...
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Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7
BackgroundThe compound 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), the promising antitumor agent developed in our laboratory was...
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Intestinal drug transporters in pathological states: an overview
Emerging information suggests that gastrointestinal and systemic pathology states may affect expression and function of membrane transporters in the...
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Transplant drugs affect the expression of phase II and antioxidant enzymes in human carcinoma cells HepG2 but not in primary cultures of human hepatocytes: In vitro comparative study
BackgroundWe carried out a test whether or not transplant drugs such as cyclosporine A, Rapamycin (Sirolimus), Tacrolimus, Everolimus and...
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Mitochondrial biology in airway pathogenesis and the role of NRF2
A constant improvement in understanding of mitochondrial biology has provided new insights into mitochondrial dysfunction in human disease...
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Modulation of UDP-glucuronidation by acridinone antitumor agents C-1305 and C-1311 in HepG2 and HT29 cell lines, despite slight impact in noncellular systems
BackgroundAmong the studied antitumor acridinone derivatives developed in our laboratory, 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone...
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Inhibition of cytochrome P450 3A enzyme by Millettia aboensis: its effect on the pharmacokinetic properties of efavirenz and nevirapine
The chronic and comorbid nature of HIV infection necessitate the use of multiple drugs including herbs to relieve symptoms with a possible increase...
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Prediction of drug–drug interaction potential using physiologically based pharmacokinetic modeling
The occurrence of drug–drug interactions (DDIs) can significantly affect the safety of a patient, and thus assessing DDI risk is important. Recently,...
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Reduce the risk of QT interval prolongation associated with targeted cancer therapy by using arrhythmic risk stratification and prevention strategies
QT interval prolongation, a cardiotoxicity that increases the risk of fatal arrhythmia, is associated with several targeted cancer therapies,...
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Recent advances in pharmacological research on Ecklonia species: a review
The genus Ecklonia (Lessoniaceae, Phaeophyceae), commonly called kelp (brown algae), is abundant on the coasts of Japan and Korea. During the past...
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Effects of friedelin on the intestinal permeability and bioavailability of apigenin
BackgroundAlthough apigenin possesses diverse pharmacological activities, its utilization as a bioactive substance is limited by poor oral...
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Structures of Cytochrome P450 Enzymes
The protein database has > 450 entries with P450 in the title and of these there are approximately 54 unique structures. Although this sample of...