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Emerging roles of ferroptosis in liver pathophysiology
Ferroptosis is a widely recognized process of regulated cell death linking redox state, metabolism, and human health. It is considered a defense...
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Pharmacology and adverse effects of new psychoactive substances: synthetic cannabinoid receptor agonists
Over the last decade, new psychoactive substances (NPS) have continuously been the focus of the international society since their emergence on the...
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Pharmacological Activities and Pharmacokinetics of Glycycoumarin
Glycycoumarin is a representative coumarin compound with significant pharmacological activities isolated from Glycyrrhiza uralensis Fisch., Fabaceae....
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Cannabinoids in the treatment of glioblastoma
Glioblastoma (GBM) is the most prevalent primary malignant tumor of the nervous system. While the treatment of other neoplasms is increasingly more...
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Canonical transient receptor potential channels and their modulators: biology, pharmacology and therapeutic potentials
Canonical transient receptor potential channels (TRPCs) are nonselective, high calcium permeability cationic channels. The TRPCs family includes...
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Protective effects of ginsenoside-Rg2 and -Rh1 on liver function through inhibiting TAK1 and STAT3-mediated inflammatory activity and Nrf2/ARE-mediated antioxidant signaling pathway
Systemic or hepatic inflammation is caused by intraperitoneal application of lipopolysaccharide (LPS). In this study, we investigated...
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Leonurine Alleviates Alcoholic Steatohepatitis Through the TLR4/NF-κB Signalling Pathway
Leonurus japonicus Houtt., Lamiaceae, commonly called Chinese motherwort, has been used to treat inflammation and ulcerations. Leonurine is an...
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Cannabidiol may prevent the development of congestive hepatopathy secondary to right ventricular hypertrophy associated with pulmonary hypertension in rats
BackgroundPulmonary hypertension (PH) can cause right ventricular (RV) failure and subsequent cardiohepatic syndrome referred to as congestive...
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Fezolinetant in the treatment of vasomotor symptoms associated with menopause: a profile of its use
Fezolinetant (VEOZAH ™ ; Veoza ™ ), a first-in-class neurokinin 3 receptor (NK3R) antagonist, represents a promising novel non-hormonal treatment option...
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Hypoxia-inducible factors and essential hypertension: narrative review of experimental and clinical data
Hypoxia-inducible factor (HIFs) is a new class of drug developed for the management of anemia in chronic kidney disease (CKD) patients. HIFs increase...
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LJ-529, a partial peroxisome proliferator-activated receptor gamma (PPARγ) agonist and adenosine A3 receptor agonist, ameliorates elastase-induced pulmonary emphysema in mice
Chronic obstructive pulmonary disease (COPD) is the leading cause of human death worldwide. Currently available therapies for COPD mainly relieve...
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Immune-related pathogenesis and therapeutic strategies of nonalcoholic steatohepatitis
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and has become prevalent in the adult population...
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Mycophenolate mofetil attenuates concanavalin A-induced acute liver injury through modulation of TLR4/NF-κB and Nrf2/HO-1 pathways
BackgroundAcute liver injury (ALI) is a serious health condition associated with rising morbidity and sudden progression. This study was designed to...
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Evidence on the Impact of Pharmacogenetics to Treat and Manage Asthma
Asthma is a chronic airway disease that is mainly treated by inhaled corticosteroids, β2-adrenergic receptor agonists, and leukotriene modifiers....
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A novel plausible mechanism of NSAIDs-induced apoptosis in cancer cells: the implication of proline oxidase and peroxisome proliferator-activated receptor
Although pharmaco-epidemiological studies provided evidence for the anticancer potential of non-steroidal anti-inflammatory drugs (NSAIDs), the...
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The potential of therapeutic strategies targeting mitochondrial biogenesis for the treatment of insulin resistance and type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) is a persistent metabolic disorder marked by deficiencies in insulin secretion and/or function, affecting various...
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Various Formulations of Glycyrrhizic Acid and the Possibility of Their Use in Virus-Associated and Inflammatory Diseases
Pharmaceuticals containing glycyrrhizic acid that exhibit a pleiotropic effect and reduce the risk of progression of cervical lesions associated with...
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Review on pharmacological effects of gastrodin
Gastrodia elata Blume is a well-known traditional Chinese medicine that is mainly used to treat diseases related to the nervous system, such as...
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Mouse models of nonalcoholic steatohepatitis and their application to new drug development
Nonalcoholic steatohepatitis (NASH) is one of the important liver diseases currently attracting attention in liver research and drug development....
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Linzagolix in moderate to severe symptoms of uterine fibroids: a profile of its use
Linzagolix (Yselty ® ) is an orally administered gonadotropin-releasing hormone receptor antagonist approved in the EU for the treatment of moderate to...
