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Synthesis and evaluation of antitumor activity of novel 1,4-Naphthoquinone derivatives (IV)
1,4-Naphthoquinones are widely distributed in nature and many clinically important antitumor drugs containing a quinone moiety, such as...
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Synthesis of Trinorditerpenoid Derivatives and Evaluation of Antimicrobial and Cytotoxic Activity
The synthesis of optically active trinorditerpenes was carried out, and their antimicrobial and antitumor activity was tested. The synthetic...
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Synthesis of DNA Using a New Two-Step Cycle
For the first time a new, two-step method is described for synthesizing deoxyribonucleic acid. The approach uses 5′-carbonate protected... -
Synthesis and Biological Activity of Hydroxyphencyclidine Homologs
A series of phencyclidine homologs was synthesized by reductive cyclization of substituted ω-chlorine-substituted l-N-[l-( p -hydroxybenzyl)cyclohexyl]a...
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Synthesis and evaluation of antitumor activity of 2- and 6-[(1,3-benzothiazol-2-yl)aminomethyl]-5,8-dimethoxy-1,4-naphthoquinone derivatives
2- or 6-Substituted BZT-N derivatives were synthesized, and their cytotoxic activity against cancer L1210 and SNU-1 cells was examined. The antitumor...
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Synthesis and antiviral activity of novel methylene cyclopropyl nucleosides
Novel exomethylene cyclopropyl nucleosides were synthesized as potential antiviral agents. The key intermediate 5 was synthesized in 4 steps, from...
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Synthesis ofLepidoptera pheromones using acetylenes
Syntheses of acetogenin pheromones using acetylene derivatives are reviewed.
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Development of new dihydropyran linker for solid-phase reaction
The linker which plays a role in connecting a polymer with a scaffold has become an important part in solid-phase reaction. To develop a new linker...
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The synthesis of labeled sterols
This review presents a discussion of methods for the chemical synthesis of sterols labeled with hydrogen and carbon isotopes.
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The chemical synthesis of sterols: Latest advances
This review discusses the results of investigations on the chemical synthesis of sterols during 1981–1996.
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Olefination of aliphatic aldehydes in the synthesis of mono-, di-, and trienic pheromones of linear structure
This review systematizes information published mainly in the last 15 years on the use of the olefination of aliphatic aldehydes (the Wittig reaction...
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Reactivity and suitability oft-boc-protected thiophosphotyrosine intermediate analogs for the solid or solution phase peptide synthesis
N-(tert -Butoxycarbonyl)- O -(dimethylthiophosphono)-L-tyrosine ( 6 ) and N-(tert -butoxycarbony)- O -(dicyanoethylthiophosphono)-L-tyrosine ( 15 ) were...
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Synthesis ofAchlya polyhydroxysteroids
This review generalizes the results of investigations on the chemical synthesis of sex hormones of aquatic fungi of the Achlya genus.
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Recent advances in the chemical synthesis of ecdysteroids and compounds related to them
This review generalizes information on methods of synthesizing ecdysteroids and substances structurally close to them published in the literature...