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DPP-4 inhibitors and type 2 diabetes mellitus in Parkinson’s disease: a mutual relationship
Parkinson’s disease (PD) usually occurs due to the degeneration of dopaminergic neurons in the substantia nigra (SN). Management of PD is restricted...
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Study of assessment of knowledge and understanding for co** with sick days among patients with diabetes in community pharmacy: a cluster randomized controlled trial (SAKURA trial)
BackgroundAwareness regarding co** with sick days among patients with diabetes is limited. Thus, we evaluated the effectiveness of sick-day...
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Antiglycative Effect of Combination of Extracts of Capsicum annuum (chilli) and Pyridoxamine Against Glycation in Streptozotocin-induced Experimental Diabetes in Rats
Glycation causes the formation of advanced glycation end products, which play an important role in the pathogenesis of diabetic complications, which...
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Effect of metformin on the long non-coding RNA expression levels in type 2 diabetes: an in vitro and clinical trial study
BackgroundIt has been suggested that the anti-hyperglycemic effect of metformin could be associated with its impact on long non-coding RNA (lncRNA)...
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Therapeutic Effects of Berberine in Metabolic Diseases and Diabetes Mellitus
The incidences of diabetes mellitus and other metabolic diseases are increasing worldwide. However, the current treatments for diabetes mellitus and...
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Development of pharmacogenomic algorithm to optimize nateglinide dose for the treatment of type 2 diabetes mellitus
BackgroundNateglinide is a meglitinide used for the treatment of type 2 diabetes mellitus. Individual studies demonstrated the association of CYP2C9,...
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Using government data to understand the use and availability of medicines for hypertension and diabetes: lessons from Peru
BackgroundRegular measurement of the availability and use of key medicines for non-communicable diseases allows the tracking of progress to achieve...
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Hypoglycemic Activity of Glycyrrhizic Acid and Some of its Derivatives in the Alloxan Diabetes Model in Rats
The hypoglycemic activity of glycyrrhizic acid (GA, I ), its trisodium ( II ) and sodium-dilithium salts ( III ), and a conjugate with L -methionine methyl...
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Protein tyrosine phosphatases (PTPs) in diabetes: causes and therapeutic opportunities
Protein tyrosine phosphatases (PTPs) have an emerging paradigm for the development of antidiabetic drugs. Herein, we provide a comprehensive overview...
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Structure – Activity Relationship and Therapeutic Benefits of Flavonoids in the Management of Diabetes and Associated Disorders
Commonly flavonoids are the natural components found in vegetables, spices and colored fruits. Flavonoids include a large group of polyphenolic...
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Differences in glycemic control between the treatment arms in cardiovascular outcome trials of type 2 diabetes medications do not explain cardiovascular benefits
Hyperglycemia is an undisputed epidemiological risk factor for microvascular complications in both type 1 and type 2 diabetes, integral in their...
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Could nutrient supplements provide additional glycemic control in diabetes management? A systematic review and meta-analysis of randomized controlled trials of as an add-on nutritional supplementation therapy
This systematic review and meta-analysis assessed the antidiabetic effect of pharmaconutrients as an add-on in type 2 diabetes mellitus patients by...
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Dose-Dependent Effect of Nerve Growth Factor Mimetic GK-2 in a Wistar Rat Diabetes Model
Experimental results for the new nerve growth factor (NGF) mimetic GK-2 [ bis -( N -monosuccinyl- L -glutamyl- L -lysine)hexamethylenediamide] administered...
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Empagliflozin mitigates type 2 diabetes-associated peripheral neuropathy: a glucose-independent effect through AMPK signaling
Diabetic peripheral neuropathy (DPN) represents a severe microvascular condition that dramatically affects diabetic patients despite adequate...
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Diabetes, hypertension and dyslipidemia medication prescribing in Qatari primary care settings: a retrospective analysis of electronic medical records
BackgroundGlobally, non-communicable diseases (NCDs) are recognised as a leading cause of morbidity and mortality. Medications and medicines...
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Cryptotanshinone ameliorates placental oxidative stress and inflammation in mice with gestational diabetes mellitus
Gestational diabetes mellitus (GDM) is a conditional diabetes which is defined as any degree of glucose intolerance or high blood glucose levels...
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The role of glucagon-like peptide-1/GLP-1R and autophagy in diabetic cardiovascular disease
Diabetes leads to a significantly accelerated incidence of various related macrovascular complications, including peripheral vascular disease and...
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Curcumin derivatives for Type 2 Diabetes management and prevention of complications
Type 2 diabetes Mellitus (T2DM) is characterized by chronically increased blood glucose levels, which is associated with impairment of the...
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Faecal Untargeted Metabolomics Analysis Elucidates the Antihyperglycaemic Effect of Surfactin in High-Fat Diet/Streptozotocin-Induced Type 2 Diabetic Mice
Type 2 diabetes mellitus is accompanied by hyperglycaemia, liver dysfunction and intestinal dysbiosis. Bioactive peptides, as functional food,...
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Insulin degludec/liraglutide in type 2 diabetes: a profile of its use
Subcutaneous insulin degludec/liraglutide (Xultophy™) is a titratable, fixed-ratio combination of a long-acting insulin analogue and a glucagon-like...
