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Synthesis of 2-(allylthio)pyrazines as a novel cancer chemopreventive agent
2-(Allylthio)pyrazine derivatives were designed as a novel cancer chemopreventive agent that functions through selective inhibtion of cytochrome...
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Sphingolipid metabolic changes during chiral C2-ceramides induced apoptosis in human leukemia cells
N -acetylsphingosine (C2-ceramide) is a synthetic water-soluble ceramide mimicking the activity of natural ceramides. By fixing chiral conformation on...
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Gene Therapy in Cardiovascular Disease
Cardiovascular disease is the leading cause of mortality and morbidity in developed countries. Most conventional therapy is often inefficacious and...
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Signal transduction events elicited by natural products: Role of MAPK and caspase pathways in homeostatic response and induction of apoptosis
Many natural products elicit diverse pharmacological effects. Using two classes of potential chemopreventive compounds, the phenolic compounds and...
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Comfrey
Symphytum officinale (L.), S. tuberosum, Sympytum × uplandicum Nyman (Russian comfrey, a hybrid of S. officinale and S. asperum)...
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Biotransformation of theophylline in cirrhotic rats induced by biliary obstruction
The object of this work was to study the pharmacokinetic differences and the cause of these differences in cirrhotic rats induced by biliary...
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Chemopreventive effects of 2-(Allylthio)pyrazine
A series of organosulfur compounds were synthesized with the aim of develo** chemopreventive compounds active against hepatotoxicity and chemical...
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Degradation of acharan sulfate and heparin byBacteroides stercoris HJ-15, a human intestinal bacterium
When glycosaminoglycan (GAG)-degrading enzymes were measured in normal human stool suspensions, all 5 tested different stools degraded titrable...
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Tryptanthrins and Other Tryptophan-Derived Agonists of the Dioxin Receptor
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related environmental pollutants exert most of their adverse effects via the aryl hydrocarbon or...
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Fluoropyrimidines as Antifolate Drugs
5 Fluorouracil (5FU) is a rationally designed antineoplastic agent (1,2) with distinct antifolate and antipyrimidine properties. 5FU is usually given...
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The Scientific Basis of Drug-Drug Interactions: Mechanism and Preclinical Evaluation
Pharmacokinetic drug-drug interactions (PDDI), in which the pharmacokinetic clearance of one drug is altered by a coadministered drug, can be divided...
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Management of Advanced Breast Cancer: Defining the Role of Toremifene
Breast cancer is an important cause of morbidity and mortality in women. Although many risk factors are thought to influence the development of...
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Effects of I.C.V. administration of ethylcholine aziridinium (AF64A) on the central glutamatergic nervous systems in rats
Changes in glutamatergic nervous activities following intracerebroventricular (icv) administration of ethylcholine aziridinium (AF64A) were studied...
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Pharmacokinetics of LB20304, a new fluoroquinolone, in rats and dogs
The pharmacokinetics of LB20304 was investigated following intravenous (IV) and oral administration to rats and dogs. Additionally, in vitro ...
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Metabolism of glycyrrhizin and baicalin by human intestinal bacteria
By human intestinal bacteria, glycyrrhizin (18β-glycyrrhetic acid β-D-glucuronyl α-D-glucuronic acid, GL) and baicalin (baicalein β-D-glucuronic...
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The Proliferating P450s: Providers of Polysubstrate Pharmacology
Over 300 P450s have been cloned and sequenced. A gene superfamily composed of at least 36 gene families has been described in 31 eukaryotes...
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Dietary Effects on Drug Metabolism
In this chapter, we discuss the interactions of food and drugs. The effects of food on the absorption of drugs and the molecular basis by which...
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The Effect of Animal Age on Tumor Induction
One of the major factors that affects the induction of cancer by chemical compounds, and which has not yet been thoroughly investigated, is the age...
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Inhibition of Chemical Carcinogenesis
More than 1500 naturally occurring and synthetic chemicals have been tested for inhibition of chemically induced carcinogenesis in experimental...