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Drug Safety in Pregnancy: Data, Methods, and Challenges
This entry provides an overview of how drug safety research in pregnancy is conducted, the challenges faced when undertaking this type of work, and...
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Polygonogram with isobolographic synergy for three-drug combinations of phenobarbital with second-generation antiepileptic drugs in the tonic–clonic seizure model in mice
BackgroundCombination therapy consisting of two or more antiepileptic drugs (AEDs) is usually prescribed for patients with refractory epilepsy. The...
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Sotalol does not interfere with the antielectroshock action of selected second-generation antiepileptic drugs in mice
BackgroundDue to blocking β-receptors, and potassium KCNH2 channels, sotalol may influence seizure phenomena. In the previous study, we have shown...
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Pharmacovigilance to Inform Drug Safety: Challenges and Opportunities
Pharmacovigilance is vital to ensure the short-term and long-term safety of medications and other medicinal substances. Both active and passive...
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Studies on the Potential Vehicles (Co-Vehicles) for Formulating Intranasal Solution of Lamotrigine
Lamotrigine, an antiepileptic agent belonging to class II of the Biopharmaceutical Classification System (BCS), has linear pharmacokinetics and wide...
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Eczematous drug eruptions mostly manageable with emollients and corticosteroids
Eczematous drug eruptions (EDEs) constitute up to 10% of cutaneous drug reactions, with biologics and some newer cancer treatments and antivirals...
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Revisiting clinical practice in therapeutic drug monitoring of first-generation antiepileptic drugs
Due to the complex and diverse nature of epilepsy and antiepileptic drugs (AEDs), the implementation of therapeutic drug monitoring (TDM) can...
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Effect of Bumetanide Administration on the Pharmacoresistant Seizure to Lamotrigine in Electrical Amygdala Kindled Rats
In recent decades, 30 – 40 percent of epilepsy patients did not get relief from seizures by antiepileptic medications. In the present study, the...
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Anticonvulsant and neurotoxic effects of a novel 1,2,4-triazole-3-thione derivative (TPF-34) and its isobolographic interaction profile with classical antiepileptic drugs in mice
BackgroundAnticonvulsant and acute toxic effects of 5-[(3-fluorophenyl)ethyl]-4-( n -hexyl)-2,4-dihydro-3 H -1,2,4-triazole-3-thione (TPF-34)—a...
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Consider clinically relevant drug interactions when prescribing edoxaban
Edoxaban, a factor Xa inhibitor, is a direct oral anticoagulant (DOAC). DOACs may have a lower incidence of drug-drug interactions (DDIs) than...
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Presynaptic antiseizure medications - basic mechanisms and clues for their rational combinations
Among clinically highly efficient antiseizure medications (ASMs) there are modifiers of the presynaptic release machinery. Of them, levetiracetam and...
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Role of clinical pharmacists in epilepsy management at a general hospital in Vietnam: a before-and-after study
BackgroundClinical pharmacists have an important role in inter-professional healthcare collaboration for epilepsy management. However, the pharmacy...
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Preparation of Cinnamon-Coated Cerium Oxide Nanoparticles and Evaluation of their Anticonvulsant Effect in Rats
This study was aimed at evaluating the effects of cinnamon-coated cerium oxide nanoparticles as a new drug for treatring pentylenetetrazole-induced...
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Teratogenic potential of third-generation antiepileptic drugs: Current status and research needs
The aim of this review was to scrutinize the current literature available on teratogenic safety of third-generation antiepileptic drugs (TGAEDs)...
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Changes in Medication Use During Pregnancy for Women with Chronic Conditions: An Analysis of Claims Data
PurposeEvaluation of drug safety during pregnancy is dependent on the number of exposed women during routine clinical practice with data available...
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Consider potential drug interactions when starting combination therapy with antiepileptic drugs
Alternative monotherapy and adjunctive therapy are both valid options following failure of initial monotherapy with an antiepileptic drug (AED)....
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Risk of Cleft Lip and/or Palate Associated With Antiepileptic Drugs: Postmarketing Safety Signal Detection and Evaluation of Information Presented to Prescribers and Patients
BackgroundThe aim was to analyze safety data associated with the maternal use of antiepileptic drugs in pregnancy and to assess the risk of cleft lip...
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Effect of caffeine on the anticonvulsant action of pregabalin against electroconvulsions in mice
BackgroundExperimental data indicate that caffeine (CAF) can reduce the anticonvulsant activity of antiepileptic drugs (AEDs) in animal models of...
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Influence of salbutamol on the anticonvulsant potency of the antiepileptic drugs in the maximal electroshock-induced seizures in mice
Backgroundβ 2 -Adrenergic receptor agonists are widely used agents in the treatment of asthma or preterm labor. Since prevalence of asthma was shown...