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Mitochondrial targeted antioxidants as potential therapy for huntington’s disease
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by an expansion in CAG repeat on huntington (Htt) gene, leading to a...
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Insulin resistance, clinical presentation and resistance to selective serotonin and noradrenaline reuptake inhibitors in major depressive disorder
BackgroundThe understanding of mechanisms underlying non-response to antidepressants is limited. The latest data highlights the role of insulin...
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Take an individualized approach when managing women of reproductive age with uterine fibroids
Uterine fibroids are the most common gynaecological tumour in women of reproductive age and can cause heavy menstrual bleeding, anaemia, pelvic pain,...
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Medication errors in older patients: a pharmacovigilance perspective
IntroductionDrug regulatory agencies are particularly interested in pharmacovigilance data relating to medication errors (MEs) involving a...
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Long-term topical corticosteroid treatment for atopic dermatitis: an in-depth analysis of safety, efficacy, withdrawal, and patient experiences
Atopic dermatitis, often referred to as eczema, is classified as a chronic inflammatory skin disorder with increasing prevalence. Topical...
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Uncovering the unique characteristics of different groups of 5-HT5AR ligands with reference to their interaction with the target protein
BackgroundThe serotonin 5-HT 5A receptor has attracted much more research attention, due to the therapeutic potential of its ligands being...
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Corticosteroids are still first-line therapies for bullous pemphigoid, with biologics finding use in difficult-to-treat disease
Bullous pemphigoid is an autoantibody-mediated subepidermal blistering disorder which develops predominately in patients of advanced age....
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Advances in the anti-tumor mechanisms of saikosaponin D
Saikosaponin D, a saponin compound, is extracted from Bupleurum and is a principal active component of the plant. It boasts a variety of...
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Efficiency of eSource Direct Data Capture in Investigator-Initiated Clinical Trials in Oncology
BackgroundClinical trials have become larger and more complex. Thus, eSource should be used to enhance efficiency. This study aimed to evaluate the...
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Research progress of propofol in alleviating cerebral ischemia/reperfusion injury
Ischemic stroke is a leading cause of adult disability and death worldwide. The primary treatment for cerebral ischemia patients is to restore blood...
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Adis summary of research: Matching‑adjusted indirect comparisons of diroximel fumarate, ponesimod, and teriflunomide for relapsing multiple sclerosis
Several oral disease-modifying therapies (DMTs) have been approved for the treatment of relapsing multiple sclerosis (MS), including diroximel...
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Mutagenic Azido Impurities in Drug Substances: A Perspective
Contamination of drug products and substances containing impurities is a significant concern in the pharmaceutical industry because it may impact the...
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Can probiotics be used in the prevention and treatment of bronchial asthma?
Asthma is a lifelong condition with varying degrees of severity and susceptibility to symptom control. Recent studies have examined the effects of...
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Interactions between metabotropic glutamate and CB1 receptors: implications for mood, cognition, and synaptic signaling based on data from mGluR and CB1R-targeting drugs
Metabotropic glutamate receptors (mGluRs) are part of the G protein-coupled receptors (GPCRs) family. They are coupled to G αq (group I) or G i/o ...
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Mechanistic insights on TLR-4 mediated inflammatory pathway in neurodegenerative diseases
Neurodegenerative diseases (NDDs) pose a significant issue in healthcare, needing a thorough knowledge of their complex molecular mechanisms. A...
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A derivative of 3-(1,3-diarylallylidene)oxindoles inhibits dextran sulfate sodium-induced colitis in mice
BackgroundIA-0130 is a derivative of 3-(1,3-diarylallylidene)oxindoles, which is a selective estrogen receptor modulator (SERM). A previous study...
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Qualitative Analysis of Inquiries Received by FDA Regarding Conduct of Clinical Trials during the Covid-19 Public Health Emergency
BackgroundThis report describes the U.S. Food and Drug Administration (FDA) experience in establishing a dedicated mailbox, and in publishing related...
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Multi-layered metabolic effects of trehalose on the liver proteome in apoE-knockout mice model of liver steatosis
BackgroundMetabolic dysfunction-associated fatty liver disease has been well documented as a key independent risk factor for the development of...
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Use of Seamless Study Designs in Oncology Clinical Development– A Survey Conducted by IDSWG Oncology Sub-team
Seamless study designs have the potential to accelerate clinical development. The use of innovative seamless designs has been increasing in the...
