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Roles of lncRNA LVBU in regulating urea cycle/polyamine synthesis axis to promote colorectal carcinoma progression
Altered expression of Urea Cycle (UC) enzymes occurs in many tumors, resulting a metabolic hallmark termed as UC dysregulation. Polyamines are...
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Association between urea trajectory and protein dose in critically ill adults: a secondary exploratory analysis of the effort protein trial (RE-EFFORT)
BackgroundDelivering higher doses of protein to mechanically ventilated critically ill patients did not improve patient outcomes and may have caused...
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Citrulline in the management of patients with urea cycle disorders
BackgroundTreatment recommendations for urea cycle disorders (UCDs) include supplementation with amino acids involved in the urea cycle (arginine...
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Neuroimaging findings of inborn errors of metabolism: urea cycle disorders, aminoacidopathies, and organic acidopathies
Although there are many types of inborn errors of metabolism (IEMs) affecting the central nervous system, also referred to as neurometabolic...
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Preoperative blood urea nitrogen-to-serum albumin ratio for prediction of in-hospital mortality in patients who underwent emergency surgery for acute type A aortic dissection
The study aimed to assess the predictive value of blood urea nitrogen (BUN)-to-albumin ratio (BA-R) for in-hospital mortality in patients undergoing...
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Synthesis and evaluation of new magneto-fluorescent carbon dot based on manganese citrate for MRI imaging
ObjectiveMedical imaging techniques have widely revolutionized the diagnosis and treatment of various health conditions. Among these techniques,...
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Halogen Replacement on the Lysine Side Chain of Lys-Urea-Glu-Based PSMA Inhibitors Leads to Significant Changes in Targeting Properties
PurposeInvestigate the impact of various halogens on pharmacokinetics, biodistribution, and micro positron emission tomography/computed tomography...
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Urea in Dermatology: A Review of its Emollient, Moisturizing, Keratolytic, Skin Barrier Enhancing and Antimicrobial Properties
Urea is a hygroscopic molecule (capable of absorbing water) present in the epidermis as a component of the natural moisturizing factor (NMF) and is...
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Association between early blood urea nitrogen-to-albumin ratio and one-year post-hospital mortality in critically ill surgical patients: a propensity score-matched study
BackgroundBlood urea nitrogen to albumin ratio (BAR) is increasingly recognized as an early predictor for short-term outcomes in critically ill...
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The correlation study between blood urea nitrogen to serum albumin ratio and prognosis of patients with sepsis during hospitalization
BackgroundSepsis is a common critical illness in intensive care unit (ICU) and seriously threatens the life of patients. Therefore, to identify a...
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68Ga-labeled ODAP-Urea-based PSMA agents in prostate cancer: first-in-human imaging of an optimized agent
PurposeProstate-specific membrane antigen (PSMA) is a promising target for prostate cancer imaging and therapy. The most commonly used scaffold...
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Sulfur, fresh cassava root and urea independently enhanced gas production, ruminal characteristics and in vitro degradability
BackgroundTotal fresh cassava root (FCR) production was 275 million tonnes in 2018 which equals 61.1 % of the total production, and Thailand produced...
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Management of late onset urea cycle disorders—a remaining challenge for the intensivist?
BackgroundHyperammonemia caused by a disorder of the urea cycle is a rare cause of metabolic encephalopathy that may be underdiagnosed by the adult...
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tRF-Gln-CTG-026 ameliorates liver injury by alleviating global protein synthesis
tsRNAs (tRNA-derived small RNAs), as products of the stress response, exert considerable influence on stress response and injury regulation. However,...
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Leucine‑enriched essential amino acids promote muscle protein synthesis and ameliorate exercise-induced exhaustion in prolonged endurance exercise in rats
BackgroundLong-term endurance exercise results in muscle damage as well as muscle protein synthesis (MPS). Recovery from endurance exercise leads to...
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Trans-cyclooctene—a Swiss army knife for bioorthogonal chemistry: exploring the synthesis, reactivity, and applications in biomedical breakthroughs
BackgroundTrans -cyclooctenes (TCOs) are highly strained alkenes with remarkable reactivity towards tetrazines (Tzs) in inverse electron-demand...
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Ammonia scavenger and glutamine synthetase inhibitors cocktail in targeting mTOR/β-catenin and MMP-14 for nitrogen homeostasis and liver cancer
The glutamine synthetase (GS) facilitates cancer cell growth by catalyzing de novo glutamine synthesis. This enzyme removes ammonia waste from the...
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Metabolomic analysis for asymptomatic hyperuricemia and gout based on a combination of dried blood spot sampling and mass spectrometry technology
BackgroundGout is the most common inflammatory arthritis and closely related to metabolic syndrome, leading to excruciating pain and the decline in...
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Amino acid losses are lower during pre-dilution on-line HDF than HD of the same Kt/V for urea
In this study, we investigated differences in amino acid losses between HD and pre-dilution on-line HDF with equal Kt/V for urea to determine which...
