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Paracellular permeability and tight junction regulation in gut health and disease
Epithelial tight junctions define the paracellular permeability of the intestinal barrier. Molecules can cross the tight junctions via two distinct...
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Slit2–Robo4 signal pathway and tight junction in intestine mediate LPS-induced inflammation in mice
BackgroundSepsis is one of the most common clinical diseases, which is characterized by a serious and uncontrollable inflammatory response....
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A flavonoid rich standardized extract of Glycyrrhiza glabra protects intestinal epithelial barrier function and regulates the tight-junction proteins expression
BackgroundIntestinal epithelial barrier dysfunction predisposes to many gastrointestinal, metabolic, and psychological disorders. A flavonoid rich...
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Effects of topical application of resveratrol on tight junction barrier and antimicrobial compound production in lactating goat mammary glands
In mammary glands, the formation of less-permeable tight junctions (TJs) and the production of antimicrobial compounds like lactoferrin and defensins...
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Valine Treatment Enhances Antimicrobial Component Production in Mammary Epithelial Cells and the Milk of Lactating Goats Without Influencing the Tight Junction Barrier
The production of antimicrobial components and the formation of less-permeable tight junctions (TJs) are important in the defense system of lactating...
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Tight junction protein 1 promotes vasculature remodeling via regulating USP2/TWIST1 in bladder cancer
Bladder cancer (BLCA) is the most common malignant tumor of the urinary system and is characterized by high metastatic rates and poor prognosis. The...
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Blood-brain barrier associated tight junction disruption is a hallmark feature of major psychiatric disorders
Major psychiatric disorders affect 25% of the population. While genetic and environmental risk factors have been identified, the underlying...
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Effects of Taraxacum mongolicum Hand.-Mazz. (dandelion) on growth performance, expression of genes coding for tight junction protein and mucin, microbiota composition and short chain fatty acids in ileum of broiler chickens
BackgroundDandelion is becoming an exploitable alternative to the widely prohibited antibiotics in the poultry production. This research aimed to...
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Functional analysis reveals calcium-sensing receptor gene regulating cell–cell junction in renal tubular epithelial cells
PurposeCalcium-sensing receptor (CASR) influences the expression pattern of multiple genes in renal tubular epithelial cells. The objective of this...
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Expression of tricellular tight junction proteins and the paracellular macromolecule barrier are recovered in remission of ulcerative colitis
BackgroundUlcerative colitis (UC) has a relapsing and remitting pattern, wherein the underlying mechanisms of the relapse might involve an enhanced...
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Post-Weaning Exposure to Sunset Yellow FCF Induces Changes in Testicular Tight and Gap Junctions in Rats: Protective Effects of Coenzyme Q10
Studies on adverse health consequences of azo dyes are limited and conflicting. Coenzyme Q10 (CoQ10) supplementation has been shown to have benefits...
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Lipid metabolism and neuromuscular junction as common pathways underlying the genetic basis of erectile dysfunction and obstructive sleep apnea
Erectile dysfunction (ED) incidence is higher in patients with obstructive sleep apnea (OSA). Studies have suggested that ED and OSA may activate...
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miR-122-5p regulates the tight junction of the blood-testis barrier of mice via occludin
BackgroundOccludin protein is the primary assembling protein of TJs and the structural basis for tight junction formation between Sertoli cells in...
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Brain tight junction protein expression in sepsis in an autopsy series
BackgroundNeuroinflammation often develops in sepsis along with increasing permeability of the blood-brain barrier (BBB), which leads to septic...
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Berberine Enhances Intestinal Mucosal Barrier Function by Promoting Vitamin D Receptor Activity
ObjectiveTo evaluate if berberine can act on vitamin D receptors (VDR) and thereby regulate the expression of tight junction proteins (TJPs) in...
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Antiviral effects of ergosterol peroxide in a pig model of porcine deltacoronavirus (PDCoV) infection involves modulation of apoptosis and tight junction in the small intestine
Porcine deltacoronavirus (PDCoV) is a newly discovered swine enteropathogenic coronavirus with worldwide distribution. However, efficient strategies...
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Cooperative cell–cell actin network remodeling to perform Gap junction endocytosis
BackgroundThe endocytosis of Gap junction plaques (GJP) requires cytoskeletal forces to internalize such large membranous structures. Actin, which...
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New therapeutic target molecules for gastric and gastroesophageal junction cancer
Molecularly targeted therapy for receptor tyrosine kinases (RTKs) has faced limitations in gastric and gastroesophageal junction (G/GEJ) cancer...
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Differential impact of yeast cell wall products in recovery of porcine intestinal epithelial cell barrier function following Lipopolysaccharide challenge
BackgroundIn swine intestinal barrier deterioration can be caused by exposure to harmful bacteria, toxins or contaminants that can lead to a leaky...
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Teduglutide Promotes Epithelial Tight Junction Pore Function in Murine Short Bowel Syndrome to Alleviate Intestinal Insufficiency
BackgroundIn short bowel syndrome, epithelial surface loss results in impaired nutrient absorption and may lead to intestinal insufficiency or...
