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Pneumatic displacement with intravitreal tPA injection versus vitrectomy with sub retinal tPA injection in small and medium sub macular hemorrhages- a multicenter comparative study
PurposeComparing between the visual outcomes and post operative complications of two surgical treatments for sub macular hemorrhage, pars plana...
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Metal ion chelation enhances tissue plasminogen activator (tPA)-induced thrombolysis: an in vitro and in vivo study
Stroke is the third leading cause of death in the United States and the leading cause of adult disability. Despite enormous research efforts...
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Causes, Predictors, and Timing of Early Neurological Deterioration and Symptomatic Intracranial Hemorrhage After Administration of IV tPA
BackgroundAcute ischemic stroke (AIS) is a major contributor toward healthcare-associated costs and services. Symptomatic intracranial hemorrhage...
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COVID-19 patient plasma demonstrates resistance to tPA-induced fibrinolysis as measured by thromboelastography
Patients critically ill with COVID-19 are at risk for thrombotic events despite prophylactic anticoagulation. Impaired fibrinolysis has been proposed...
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Comparison of subretinal aflibercept vs ranibizumab vs bevacizumab in the context of PPV, pneumatic displacement with subretinal air and subretinal tPA in naïve submacular haemorrhage secondary to nAMD. “The Submarine Study”
ObjectiveTo compare efficacy and safety profile of subretinal aflibercept, ranibizumab, and bevacizumab in the context of pars plana vitrectomy,...
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Successful use of tPA for thrombolysis in COVID related ARDS: a case series
We describe successful usage of low dose Tissue plasminogen activator (tPA) (30–50 mg) in three COVID19 critically ill patients, who were in...
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The typical polypoid adenomyoma is a special form of endometrial polyp: a case-controlled study with a large sample size
PurposeTo investigate clinicopathological differences between typical endometrial polypoid adenomyomas (TPAs) and endometrial polyps (EPs) and to...
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Tenecteplase versus alteplase before stroke thrombectomy: outcomes after system-wide transitions in Pennsylvania
IntroductionUnited States stroke systems are increasingly transitioning from alteplase (TPA) to tenecteplase (TNK). Real-world data on the safety and...
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How the trabeculae protrude within the left atrial appendage is the key factor affecting thrombosis in patients with atrial fibrillation
The left atrial appendage (LAA) is a major site of thrombosis in patients with non-valvular atrial fibrillation. The myocardial trabeculae within the...
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The efficacy and safety of tenecteplase compared with alteplase in adult patients with acute ischemic stroke: an updated systematic review and meta-analysis of ten randomized controlled trials
BackgroundAlteplase (tPA) is the only thrombolytic agent approved by the USFDA for acute ischemic stroke (AIS). Various randomized controlled trials...
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Comparative Analysis of Transpedal and Transfemoral Access During Genicular Artery Embolization for Knee Osteoarthritis
PurposeThis retrospective study aimed to compare the efficacy and safety of transpedal access (TPA) with transfemoral access (TFA) in Genicular...
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Anomalous origin of the temporopolar artery from the internal carotid artery and aneurysms at the temporopolar and internal carotid arteries: a very rare case report
The temporopolar artery (TPA) originates directly from the sphenoidal segment of the middle cerebral artery (MCA). Its originating from the M1...
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Impact of skeletal muscle mass on the prognosis of patients undergoing neoadjuvant chemotherapy for resectable or borderline resectable pancreatic cancer
BackgroundNeoadjuvant chemotherapy is a common therapeutic procedure for patients with pancreatic cancer. This study aimed to investigate the...
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Dynamic increase in neutrophil levels predicts parenchymal hemorrhage and function outcome of ischemic stroke with r-tPA thrombolysis
BackgroundThe higher level of neutrophil on admission has been reported to predict worse 3-month outcomes in ischemic stroke patients. Our study was...
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The independent and joint association of accelerometer-measured physical activity and sedentary time with dementia: a cohort study in the UK Biobank
BackgroundResearch on the association of physical activity and sedentary time with dementia is accumulating, though elusive, and the interaction...
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Salvage use of tissue plasminogen activator (tPA) in the setting of acute respiratory distress syndrome (ARDS) due to COVID-19 in the USA: a Markov decision analysis
BackgroundCOVID-19 threatens to quickly overwhelm our existing critical care infrastructure in the USA. Systemic tissue plasminogen activator (tPA)...
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Association of physical activity with MAFLD/MASLD and LF among adults in NHANES, 2017–2020
ObjectivesTo investigate the correlations between physical activity (PA) and metabolic associated fatty liver disease (MAFLD) or metabolic...
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Analysis of physical activity and prescription opioid use among US adults: a cross-sectional study
BackgroundOpioid crisis has become a global concern, but whether physical activity (PA) can effectively reduce prescription opioid use remains...
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Association between electronic device use and health status among a middle-aged and elderly population: a cross-sectional analysis in the UK Biobank
AimFew previous studies have investigated the impact of multiple types of electronic devices on health status, and the moderating effects of gender,...
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Extended sphenoidotomy combined with transpterygoid approach for sphenoidal sinus inverted papilloma
PurposeInverted papilloma of the sphenoid sinus (IPSS) is a rare tumor with debated surgical management due to its proximity to vital structures. The...
