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Fibronectin-coated polyurethane meniscal scaffolding supplemented with MSCs improves scaffold integration and proteoglycan production in a rabbit model
PurposeThe role of mesenchymal stem cells (MSC) in supporting the formation of new meniscal tissue in a meniscal scaffold is not well understood. The...
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A novel mutation in the proteoglycan 4 gene causing CACP syndrome: two sisters report
BackgroundCamptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome, caused by biallelic pathogenic mutations in the proteoglycan 4 ( PRG4 )...
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Mechanical Pressure Driving Proteoglycan Expression in Mammographic Density: a Self-perpetuating Cycle?
Regions of high mammographic density (MD) in the breast are characterised by a proteoglycan (PG)-rich fibrous stroma, where PGs mediate aligned...
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Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltration
Abstract BackgroundSynovial macrophages perform a multitude of functions that include clearance of cell debris and foreign bodies, tissue immune...
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Age-dependent microstructural changes of the intervertebral disc: a validation of proteoglycan-sensitive spectral CT
ObjectiveTo analyze the two major components of the intervertebral disc (IVD) in an ex vivo phantom, as well as age-related changes in patients.
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Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis: the iPOWER Study
Angina and no obstructive coronary artery disease (CAD) have an unfavorable prognosis, possibly due to diffuse myocardial fibrosis (DMF). In DMF the...
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Proteoglycan loss in the articular cartilage is associated with severity of joint inflammation in psoriatic arthritis—a compositional magnetic resonance imaging study
BackgroundEven though cartilage loss is a known feature of psoriatic arthritis (PsA), little is known about its role in the pathogenesis of PsA....
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ISSLS PRIZE in basic science 2023: Lactate in lumbar discs—metabolic waste or energy biofuel? Insights from in vivo MRS and T2r analysis following exercise and nimodipine in healthy volunteers
PurposeTo quantitatively assess the dynamic changes of Lactate in lumbar discs under different physiological conditions using MRS and T2r.
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Efficacy of adipose—derived stromal vascular fraction in treatment of osteoarthritis: an experimental study
BackgroundOsteoarthritis OA is a common progressive disabling disease. Current research aims at finding therapies to prevent its progression. In this...
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Proteoglycan-4 regulates fibroblast to myofibroblast transition and expression of fibrotic genes in the synovium
BackgroundSynovial tissue fibrosis is common in advanced OA with features including the presence of stress fiber-positive myofibroblasts and...
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Effects of combination of mizolastine and proteoglycan on chronic urticaria: a randomized controlled trial
The present study aimed to observe the therapeutic effect of combined mizolastine and proteoglycan in chronic urticaria. The patients were randomly...
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Role of the small proteoglycan bikunin in human reproduction
PurposeFemale reproductive events, including ovulation, menstruation, implantation, and delivery, are physiologically characterized by deep tissue...
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Correction to: Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltration
An amendment to this paper has been published and can be accessed via the original article.
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Functional MR imaging beyond structure and inflammation—radiographic axial spondyloarthritis is associated with proteoglycan depletion of the lumbar spine
BackgroundTo compare the glycosaminoglycan (GAG) content of lumbar intervertebral disks (IVDs) of patients with ankylosing spondylitis (AS) and...
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Zone- and layer-specific differences in proteoglycan content in patellofemoral pain syndrome are detectable on T1ρ MRI
ObjectiveDetermine if differences in T1ρ would be detected in specific regions or layers of patellofemoral cartilage between patients with...
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Osteomodulin downregulation is associated with osteoarthritis development
Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis (OA), and osteomodulin (OMD), a proteoglycan involved...
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Temporomandibular Joint Fibrocartilage Contains CD105 Positive Mouse Mesenchymal Stem/Progenitor Cells with Increased Chondrogenic Potential
ObjectiveA specific type of mesenchymal stem/progenitor cells (MSPCs), CD105 + is reported to aid in cartilage regeneration through...
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HAPLN3 inhibits apoptosis and promotes EMT of clear cell renal cell carcinoma via ERK and Bcl-2 signal pathways
Hyaluronan and proteoglycan link protein 3 (HAPLN3) is a member of the hyaluronan and proteoglycan link protein family expressed in the extracellular...
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Overexpression of lncRNA LINC00665 inhibits the proliferation and chondroblast differentiation of bone marrow mesenchymal stem cells by targeting miR-214-3p
BackgroundOsteoarthritis is a chronic disease mainly involving the damage of articular cartilage and the whole articular tissue, which is the main...
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Successful Treatment of Schwartz-Jampel Syndrome with Botulinum Toxin Type A
Schwartz-Jampel syndrome (SJS) is a rare autosomal recessive disorder characterized by typical facial dysmorphism, generalized muscle stiffness,...
