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A prospective cohort study of depression (PROUD) in China: rationale and design
BackgroundMajor depressive disorder (MDD) imposes a heavy global disease burden. However, current etiology, diagnosis and treatment remain...
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The China Hypertrophic Cardiomyopathy Project (CHCMP): The Rationale and Design of a Multicenter, Prospective, Registry Cohort Study
AbstractHypertrophic cardiomyopathy (HCM) is associated with adverse outcomes, such as heart failure, arrhythmia, and mortality. Sudden cardiac death...
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Rationale and design of the Birkebeiner Ageing Study – a prospective cohort study of older endurance athletes
BackgroundWhile regular physical activity is associated with reduced mortality and morbidity in general populations, health outcomes and functional...
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Rotational stability of monofocal and diffractive multifocal toric intraocular lens with identical design and material: a propensity score based prospective comparative study
PurposeTo compare the rotational stability of a monofocal and a diffractive multifocal toric intraocular lens(IOLs) with identical design and...
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The snapshot audit methodology: design, implementation and analysis of prospective observational cohort studies in surgery
PurposeFor some surgical conditionns and scientific questions, the “real world” effectiveness of surgical patient care may be better explored using a...
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PATHFINDER-CHD: prospective registry on adults with congenital heart disease, abnormal ventricular function, and/or heart failure as a foundation for establishing rehabilitative, prehabilitative, preventive, and health-promoting measures: rationale, aims, design and methods
BackgroundAdults with congenital heart defects (ACHD) globally constitute a notably medically underserved patient population. Despite therapeutic...
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The 90% effective concentration of alfentanil combined with 0.075% ropivacaine for epidural labor analgesia: a single-center, prospective, double-blind sequential allocation biased-coin design
PurposeMore literature studies have reported that alfentanil is safe and effective for labor analgesia. However, there is no unified consensus on the...
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A prospective, open-label, randomized clinical trial to evaluate the efficacy and safety of remimazolam in patients undergoing EBUS-TBNA: REST trial design
BackgroundRemimazolam is safe and effective for moderate sedation during flexible bronchoscopy, but its safety and efficacy during endobronchial...
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Concept, study design, and baseline blood pressure control status of the nationwide prospective HI–JAMP study using multisensor ABPM
The Home-Activity Information and Communication Technology (ICT)-based Japan Ambulatory Blood Pressure Monitoring Prospective (HI–JAMP) study is a...
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Merging citizen science with epidemiology: design of a prospective feasibility study of health events and air pollution in Cologne, Germany
BackgroundCitizen science as an approach to merge society and science is not a new paradigm. Yet it is not common in public health, epidemiology, or...
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Efficacy of small back optic zone design on myopia control for corneal refractive therapy (CRT): a one-year prospective cohort study
BackgroundTo investigate the control effect on the axial length elongation using corneal refractive therapy (CRT) with different optical zone...
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Role of Microbiome in the Outcomes Following Surgical Repair of Perianal Fistula: Prospective Cohort Study Design and Preliminary Results
BackgroundAnal fistulae are common, predominantly cryptoglandular, and almost invariably require surgical treatment. Recurrences are common for...
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Design, cohort profile and comparison of the KTD-Innov study: a prospective multidimensional biomarker validation study in kidney allograft rejection
There is an unmet need for robust and clinically validated biomarkers of kidney allograft rejection. Here we present the KTD-Innov...
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Multimodality treatment for brain arteriovenous malformation in Mainland China: design, rationale, and baseline patient characteristics of a nationwide multicenter prospective registry
BackgroundBrain arteriovenous malformation (AVM) is an important cause of hemorrhagic stroke in young adults, which can lead to severe neurological...
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Prospective evaluation of cardiac effects of first-time marathon training, running, and recovery in middle-aged men: cohort study rationale and design
BackgroundSeveral phenomena may point to potentially detrimental cardiac effects of endurance exercise, such as elevated circulating cardiac troponin...
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Rationale and Design of Sympathetic Map**/Ablation of Renal Nerves Trial (SMART) for the Treatment of Hypertension: a Prospective, Multicenter, Single-Blind, Randomized and Sham Procedure-Controlled Study
Renal denervation (RDN) is proposed as a durable and patient compliance independent treatment for hypertension. However, 20–30% non-responder after...
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Investigating significant health trends in growth hormone treatments registry: rationale, aims and design of a nationwide prospective registry (study protocol)
BackgroundSomatropin treatment is indicated in a variety of disorders including growth hormone (GH) deficiency, Prader–Willi and Turner syndrome,...
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Design and rationale for the prospective treatment efficacy in IPF using genotype for NAC selection (PRECISIONS) clinical trial
BackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive lung disease with few treatment options. N -acetylcysteine (NAC) is a well-tolerated,...
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Investigating significant health trends in progressive fibrosing interstitial lung disease (INSIGHTS-ILD): rationale, aims and design of a nationwide prospective registry
BackgroundThe progressive course of pulmonary fibrosis (PPF) is observed with variable prevalence in different entities of fibrosing interstitial...
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The Effect of the ENJOY Seniors Exercise Park Physical Activity Program on Falls in Older People in the Community: A Prospective Pre-Post Study Design
BackgroundThe ENJOY project (Exercise interveNtion outdoor proJect in the cOmmunitY for older people) is a community-based research project actively...
