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Aneuploidy detection in pooled polar bodies using rapid nanopore sequencing
PurposeVarious screening techniques have been developed for preimplantation genetic testing for aneuploidy (PGT-A) to reduce implantation failure and...
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Pooled genetic screens to identify vulnerabilities in TERT-promoter-mutant glioblastoma
Pooled genetic screens represent a powerful approach to identify vulnerabilities in cancer. Here we used pooled CRISPR/Cas9-based approaches to...
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Exposure to Endocrine-Disrupting Chemicals and Congenital Heart Diseases: The Pooled Results Based on the Current Evidence
The relationships between maternal exposure to endocrine-disrupting chemicals (EDCs) and congenital heart diseases (CHD) are not elucidated yet. The...
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Safety of nivolumab monotherapy in five cancer types: pooled analysis of post-marketing surveillance in Japan
BackgroundNivolumab has been approved for treating ≥ 10 cancer types. However, there is limited information on the incidence of rare, but potentially...
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Dietary intake of vitamin C and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project
BackgroundPrevious studies suggest that dietary vitamin C is inversely associated with gastric cancer (GC), but most of them did not consider intake...
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Long-Term Durability of Certolizumab Pegol in Patients with Rheumatoid Arthritis Over 5 Years: An Analysis of Pooled Clinical Trial Data
IntroductionThere is a paucity of data on how patient characteristics may affect the long-term durability of certolizumab pegol (CZP) in patients...
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DNA methylation GrimAge acceleration in US military veterans with PTSD
Epigenetic alterations in DNA methylation might mediate gene expression effects of trauma underlying PTSD symptoms, or effects of PTSD on related...
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Assessing circulating tumour DNA (ctDNA) as a prognostic biomarker in locally advanced rectal cancer: a systematic review and meta-analysis
IntroductionCirculating tumour DNA (ctDNA) has emerged as a promising biomarker in various cancer types, including locally advanced rectal cancer...
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Radium-223 in women with hormone receptor-positive bone-metastatic breast cancer receiving endocrine therapy: pooled analysis of two international, phase 2, randomized, double-blind, placebo-controlled trials
BackgroundMost women with advanced breast cancer have skeletal metastases. Radium-223 is an alpha-emitting radionuclide that selectively targets...
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Presence of pathogen DNA in milk harvested from quarters is associated to changes in cows’ milk yield and composition
BackgroundIntramammary infection is the result of invasion and multiplication of microorganisms in the mammary gland and commonly leads to mastitis...
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Central nervous system efficacy of furmonertinib (AST2818) in patients with EGFR T790M mutated non-small cell lung cancer: a pooled analysis from two phase 2 studies
BackgroundFurmonertinib (AST2818) is a brain penetrant pan-epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) targeting both EGFR ...
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Prognostic factors for pediatric, adolescent, and young adult patients with non-DIPG grade 4 gliomas: a contemporary pooled institutional experience
PurposeWHO grade 4 gliomas are rare in the pediatric and adolescent and young adult (AYA) population. We evaluated prognostic factors and outcomes in...
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Pooled analysis of patients with inherited prion disease caused by two- to twelve-octapeptide repeat insertions in the prion protein gene (PRNP)
Inherited prion diseases caused by two- to twelve-octapeptide repeat insertions (OPRIs) in the prion protein gene ( PRNP ) show significant clinical...
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Clinical significance of circulating tumor DNA in localized non-small cell lung cancer: a systematic review and meta-analysis
Circulating tumor DNA (ctDNA) detection holds promise for genetic analyses and quantitative assessment of tumor burden. A systematic review and...
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Factors affecting low fetal fraction in fetal screening with cell-free DNA in pregnant women: a systematic review and meta-analysis
BackgroundCell-Free DNA (cfDNA) is a non-invasive perinatal test (NIPT) used to assess fetal anomalies. The ability to detect fetal chromosomal...
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Self- and non-self-DNA on hands and sleeve cuffs
Studying DNA transfer and persistence has become increasingly important over the last decade, due to the impressive sensitivity of modern DNA...
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Correlation between quantitative HBsAg and quantitative HBV DNA in chronic hepatitis B patients: a systematic review and meta-analysis
BackgroundHBV DNA assays have several limitations including being expensive and not widely available. Detection of HBsAg in serum has been the...
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A meta-analysis of circulating tumor DNA as a survival indicator in small cell lung cancer patients
A high level of circulating tumor DNA (ctDNA) has been linked to poor survival in patients with certain solid tumors. In spite of this, it is still...
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Zanubrutinib Monotherapy for Naïve and Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Pooled Analysis of Three Studies
IntroductionZanubrutinib is a highly selective irreversible inhibitor of Bruton tyrosine kinase which has shown significant activity in lymphoid...
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DNA methylation in the genesis, progress and prognosis of head and neck cancer
Epigenetic alteration studies in cancer research have been progressing rapidly in recent years. DNA methylation, including DNA hypermethylation and...
