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A mammalian lung's immune system minimizes tissue damage by initiating five major sequential phases of defense
The mammalian lungs encounter several pathogens, but have a sophisticated multi-phase immune defense. Furthermore, several immune responses to...
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Piezo1 induced apoptosis of type II pneumocytes during ARDS
ObjectiveThe mechanisms of lung injury in acute respiratory distress syndrome (ARDS) are not well understood.Piezo1 was recently identified as a...
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NHLRC2 expression is increased in idiopathic pulmonary fibrosis
BackgroundVariants of NHL repeat-containing protein 2 (NHLRC2) have been associated with severe fibrotic interstitial lung disease in early childhood...
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Low let-7d microRNA levels in chick embryos enhance innate immunity against Mycoplasma gallisepticum by suppressing the mitogen-activated protein kinase pathway
Chick embryos are a valuable model for studying immunity and vaccines. Therefore, it is crucial to investigate the molecular mechanism of the Mycoplasm...
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Sputum characteristics of patients with severe COVID-19: report of two cases with immunocytochemical detection of SARS-CoV-2 spike protein
Patients with SARS-CoV-2 infection and with severe COVID-19 often have multiple coinfections, and their treatment is challenging. Here, we performed...
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Krebs von den Lungen 6 (KL-6) levels in COVID-19 ICU patients are associated with mortality
BackgroundKrebs von den Lungen 6 (KL-6) is a high-molecular-weight mucin-like glycoprotein, which is also known as MUC1. KL-6 is mainly produced by...
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COVID-19: a Disease with a Potpourri of Histopathologic Findings—a Literature Review and Comparison to the Closely Related SARS and MERS
Since the coronavirus disease 2019 (COVID-19) pandemic has hit the entire world, there is ample knowledge regarding its clinical course and...
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Oxidative stress and NF-KB/iNOS inflammatory pathway as innovative biomarkers for diagnosis of drowning and differentiating it from postmortem submersion in both fresh and saltwater in rats
BackgroundFinding a dead body in water raises an issue concerning determining the cause of death as drowning because of the complex pathophysiology...
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Vitamin D regulation of immune function during covid-19
Covid-19 has to date infected a confirmed 275 million people with 5.4 million, now dead, with the count rising every day. Although the virus,...
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The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019
BackgroundThe coronavirus disease 2019 (COVID-19) has induced a worldwide epidemiological event with a high infectivity and mortality. However, the...
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Association of androgenetic alopecia with a more severe form of COVID-19 infection
BackgroundIndividual susceptibility to develop acute respiratory distress syndrome is related to age and most frequent comorbidities. So far, it is...
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Lung tissue expression of epithelial injury markers is associated with acute lung injury severity but does not discriminate sepsis from ARDS
BackgroundAcute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in critically ill patients, and diffuse alveolar damage...
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Quercetin ameliorates acute lung injury in a rat model of hepatopulmonary syndrome
BackgroundCommon bile duct ligation (BDL) is a rat experimental model to induce biliary cirrhosis. Lung fibrosis and pulmonary vascular angiogenesis...
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Postmortem examination of three SARS-CoV-2-positive autopsies including histopathologic and immunohistochemical analysis
This paper describes three autopsy cases with postmortem diagnosis of SARS-CoV-2 infection, with detailed macroscopic examination as well as advanced...
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Enlarging pulmonary cyst: a rare form of alveolar adenoma
BackgroundAlveolar adenoma is a rare benign tumour, usually presenting as a peripherally located solid mass, sometimes mimicking malignancy.
...
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Respiratory Disorders in Neonates Born by Elective Cesarean Section
Purpose of ReviewInfants born by elective cesarean section (ECS) are at increased risk for respiratory dysfunction due to inadequate lung fluid...
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Senescence and autophagy in usual interstitial pneumonia of different etiology
Idiopathic pulmonary fibrosis (IPF) is a disease with a dismal prognosis. Currently, the causing agent(s) are poorly understood. Recent data suggest...
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A Novel Host of an Emerging Disease: SARS-CoV-2 Infection in a Giant Anteater (Myrmecophaga tridactyla) Kept Under Clinical Care in Brazil
A young male free-ranging giant anteater ( Myrmecophaga tridactyla ) was found with paralysis of pelvic limbs on a highway and kept under human care....
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Clinical, molecular, and histological characteristics of severely necrotic and fatal mpox in HIV-infected patients
BackgroundThis case series of 5 patients with severely necrotic mpox highlights the predominantly necrotic nature of lesions seen in cases of severe...
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Serial KL-6 measurements in COVID-19 patients
SARS-CoV2-induced direct cytopathic effects against type II pneumocytes are suspected to play a role in mediating and perpetuating lung damage. The...
