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Cortical spreading depression can be triggered by sensory stimulation in primed wild type mouse brain: a mechanistic insight to migraine aura generation
BackgroundUnlike the spontaneously appearing aura in migraineurs, experimentally, cortical spreading depression (CSD), the neurophysiological...
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The Critical Role of Spreading Depolarizations in Early Brain Injury: Consensus and Contention
BackgroundWhen a patient arrives in the emergency department following a stroke, a traumatic brain injury, or sudden cardiac arrest, there is no...
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Questioning Glutamate Excitotoxicity in Acute Brain Damage: The Importance of Spreading Depolarization
BackgroundWithin 2 min of severe ischemia, spreading depolarization (SD) propagates like a wave through compromised gray matter of the higher brain....
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Spreading depression as a preclinical model of migraine
Spreading depression (SD) is a slowly propagating wave of near-complete depolarization of neurons and glial cells across the cortex. SD is thought to...
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Effect of Locally Delivered Nimodipine Microparticles on Spreading Depolarization in Aneurysmal Subarachnoid Hemorrhage
BackgroundRecurrent spreading depolarizations (SDs) occur in patients after aneurysmal subarachnoid hemorrhage (aSAH), resulting in metabolic stress...
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Functional correlation of ATP1A2 mutations with phenotypic spectrum: from pure hemiplegic migraine to its variant forms
BackgroundMutations in ATP1A2 , the gene encoding the α2 subunit of Na + /K + -ATPase, are the main cause of familial hemiplegic migraine type 2 (FHM2)....
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Cortical spreading depression and migraine
Cortical spreading depression (CSD), a slowly propagated wave of depolarization followed by suppression of brain activity, is a remarkably complex...
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Possible FDA-approved drugs to treat Ebola virus infection
There is currently no effective treatment for the Ebola virus (EBOV) thus far. Most drugs and vaccines developed to date have not yet been approved...
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The first phase of a migraine attack resides in the cortex
Migraine headache is generated by the complex interaction of various players such as genetic predisposition, environmental triggers and intrinsic...
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Shedding light on mitochondrial function by real time monitoring of NADH fluorescence: I. Basic methodology and animal studies
Normal mitochondrial function in the process of metabolic energy production is a key factor in maintaining cellular activities. Many pathological...
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Migraine is a neuronal disease
Migraine is a common, paroxysmal, highly disabling primary headache disorder with a genetic background. The primary cause and the origin of migraine...
