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Roles of the medial and lateral orbitofrontal cortex in major depression and its treatment
We describe evidence for dissociable roles of the medial and lateral orbitofrontal cortex (OFC) in major depressive disorder (MDD) from structure,...
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A disinhibitory microcircuit of the orbitofrontal cortex mediates cocaine preference in mice
Both clinical and animal studies showed that the impaired functions of the orbitofrontal cortex (OFC) underlie the compulsive drug-seeking behavior...
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Adaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder
Alcohol use disorder (AUD) is a life-threatening disease characterized by compulsive drinking, cognitive deficits, and social impairment that...
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Frequency dependent emotion differentiation and directional coupling in amygdala, orbitofrontal and medial prefrontal cortex network with intracranial recordings
The amygdala, orbitofrontal cortex (OFC) and medial prefrontal cortex (mPFC) form a crucial part of the emotion circuit, yet their emotion induced...
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Orbitofrontal cortex microRNAs support long-lasting heroin seeking behavior in male rats
Recovery from opioid use disorder (OUD) and maintenance of abstinence from opioid use is hampered by perseverant drug cravings that may persist for...
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Elevated levels of serotonin 5-HT2A receptors in the orbitofrontal cortex of antisocial individuals
Antisocial behavior (ASB) is characterized by frequent violations of the rights and properties of others, as well as aggressive conduct. While ample...
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Predicting the efficacy of donepezil intervention in Alzheimer’s disease patients using regional homogeneity in the inferior orbitofrontal cortex
BackgroundAlthough donepezil is a commonly used drug for treating Alzheimer's disease (AD), the mechanisms by which it affects patients’ functional...
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Emotional intelligence mediates the protective role of the orbitofrontal cortex spontaneous activity measured by fALFF against depressive and anxious symptoms in late adolescence
As a stable personality construct, trait emotional intelligence (TEI) refers to a battery of perceived emotion-related skills that make individuals...
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Aberrant intrinsic hippocampal and orbitofrontal connectivity in drug-naive adolescent patients with major depressive disorder
Alterations in resting-state functional connectivity (rsFC) of hippocampus and orbitofrontal cortex (OFC) have been highly implicated in major...
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Medial orbitofrontal cortex and nucleus accumbens mediation in risk assessment behaviors in adolescents and adults
Risk assessment behaviors are necessary for gathering risk information and guiding decision-making. Risky decision-making heightens during...
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Limbic links to paranoia: increased resting-state functional connectivity between amygdala, hippocampus and orbitofrontal cortex in schizophrenia patients with paranoia
Paranoia is a frequent and highly distressing experience in psychosis. Models of paranoia suggest limbic circuit pathology. Here, we tested whether...
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Dissociable control of μ-opioid-driven hyperphagia vs. food impulsivity across subregions of medial prefrontal, orbitofrontal, and insular cortex
This study explored potentially dissociable functions of mu-opioid receptor (µ-OR) signaling across different cortical territories in the control of...
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Abnormalities in deep-brain morphology and orbitofrontal cortical thinning relate to reward processing and body mass in adolescent girls
BackgroundResearch examining the neural correlates of obesity has recently expanded. However, limited attention has focused on identifying unique...
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Frontomesial and orbitofrontal epilepsy
Frontal lobe epilepsy (FLE) constitutes a heterogeneous entity with distinct epilepsy subtypes based on the anatomofunctional organization of the...
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Altered brain metabolism in frontotemporal dementia and psychiatric disorders: involvement of the anterior cingulate cortex
BackgroundBehavioural symptoms and frontotemporal hypometabolism overlap between behavioural variant of frontotemporal dementia (bvFTD) and primary...
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The role of the orbitofrontal cortex and the nucleus accumbens for craving in alcohol use disorder
This study aimed to investigate structural and functional alterations of the reward system and the neurobiology of craving in alcohol use disorder...
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A paraventricular thalamus to insular cortex glutamatergic projection gates “emotional” stress-induced binge eating in females
It is well-established that stress and negative affect trigger eating disorder symptoms and that the brains of men and women respond to stress in...
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Deciphering the functional role of insular cortex stratification in trigeminal neuropathic pain
Trigeminal neuropathic pain (TNP) is a major concern in both dentistry and medicine. The progression from normal to chronic TNP through activation of...
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Medial orbitofrontal cortex dopamine D1/D2 receptors differentially modulate distinct forms of probabilistic decision-making
Efficient decision-making involves weighing the costs and benefits associated with different actions and outcomes to maximize long-term utility. The...
