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Energy Balance and Bone Health: a Nutrient Availability Perspective
Purpose of ReviewObesity is highly prevalent and is associated with bone fragility and fracture. The changing nutrient availability to bone in...
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Neuronal control of peripheral nutrient partitioning
The appropriate utilisation, storage and conversion of nutrients in peripheral tissues, referred to as nutrient partitioning, is a fundamental...
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Glucose partitioning in the bone marrow micro-environment in acute myeloid leukaemia
Acute myeloid leukaemia (AML) cells metabolise glucose by glycolysis-based re-programming. However, how glucose uptake is partitioned between...
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NAPE-PLD in the ventral tegmental area regulates reward events, feeding and energy homeostasis
The N -acyl phosphatidylethanolamine-specific phospholipase D (NAPE-PLD) catalyzes the production of N -acylethanolamines (NAEs), a family of...
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Brain insulin signalling in metabolic homeostasis and disease
Insulin signalling in the central nervous system regulates energy homeostasis by controlling metabolism in several organs and by coordinating organ...
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The regulation of hepatic fatty acid synthesis and partitioning: the effect of nutritional state
Nonalcoholic fatty liver disease (NAFLD) is an increasing global public health burden. NAFLD is strongly associated with type 2 diabetes mellitus,...
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Metabolic control of cancer metastasis: role of amino acids at secondary organ sites
Most cancer-related deaths are caused by the metastases, which commonly develop at multiple organ sites including the brain, bone, and lungs. Despite...
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Assessment of the phytochemical composition and antimicrobial properties of Tapinanthus bangwensis leaves hosted by the branches of Persea americana
BackgroundMedicinal plants represent a valuable source for new effective and safe antimicrobial drugs making them an alternative therapy. Existing...
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A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration
Adipocyte mitochondrial respiration may influence metabolic fuel partitioning into oxidation versus storage, with implications for whole-body energy...
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Amino Acid Metabolism in Bone Metastatic Disease
Purpose of ReviewBreast and prostate tumors frequently metastasize to the bone, but the underlying mechanisms for osteotropism remain elusive. An...
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Brain pharmacokinetics and metabolism of the AMP-activated protein kinase selective inhibitor SBI-0206965, an investigational agent for the treatment of glioblastoma
Purpose . Emerging evidence suggests that 5' Adenosine Monophosphate-Activated Protein Kinase (AMPK), a key regulator of cellular bioenergetics, is a...
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“A herder’s duty is to think”: landscape partitioning and folk habitats of Mongolian herders in a mountain forest steppe (Khuvsugul-Murun region)
BackgroundTraditional habitat knowledge, like the classification of folk habitats and how people partition their landscape into habitats, is an...
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Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models
The obesity pandemic continues unabated despite a persistent public health campaign to decrease energy intake (“eat less”) and increase energy...
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The effects of ghrelin and LEAP-2 in energy homeostasis are modulated by thermoneutrality, high-fat diet and aging
PurposeLiver-expressed antimicrobial peptide 2 (LEAP-2) has been recently identified as the endogenous non-competitive allosteric antagonist of the...
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Role of Placental Glucose Transporters in Determining Fetal Growth
Maternal nutrient availability and its transport through the placenta are crucial for fetal development. Nutrients are transported to the fetus via...
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Are gut dysbiosis, barrier disruption, and endotoxemia related to adipose tissue dysfunction in metabolic disorders? Overview of the mechanisms involved
Recently, compelling evidence points to dysbiosis and disruption of the epithelial intestinal barrier as major players in the pathophysiology of...
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Glutamine addiction promotes glucose oxidation in triple-negative breast cancer
Glutamine is a conditionally essential nutrient for many cancer cells, but it remains unclear how consuming glutamine in excess of growth...
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Berberine supplementation modulates the somatotropic axis and ameliorates glucose tolerance in dairy goats during late gestation and early lactation
BackgroundPregnancy, parturition, and the onset of lactation represent an enormous physiological and hormonal challenge to the homeostasis of dairy...
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The low prevalence rate of vitamin E deficiency in urban adults of Wuhan from central China: findings from a single-center, cross-sectional study
BackgroundVitamin E is an essential nutrient in human body famous for its antioxidant and non-antioxidant functions. However, little is known about...
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