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Breastfeeding and Metabolic Programming
This comprehensive and updated book focuses on breastfeeding and its long-term effects which affect health and development, providing a protective...
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Micronutrients in early life and offspring metabolic health programming: a promising target for preventing non-communicable diseases
Chronic non-communicable diseases are the leading cause of morbidity and mortality worldwide. Develo** and implementing effective preventive...
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Programming of metabolism by adipokines during development
The intrauterine and early postnatal periods represent key developmental stages in which an organism is highly susceptible to being permanently...
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Metabolic programming in the offspring after gestational overfeeding in the mother: toward neonatal rescuing with metformin in a swine model
ObjectivesMaternal overfeeding during gestation may lead to adverse metabolic programming in the offspring mediated by epigenetic alterations....
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Neonatal leptin antagonism improves metabolic programming of postnatally overnourished mice
Background/ObjectivesAlteration of the perinatal nutritional environment is an important risk factor for the development of metabolic diseases in...
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Maternal obesity and programming of metabolic syndrome in the offspring: searching for mechanisms in the adipocyte progenitor pool
BackgroundIt is now understood that it is the quality rather than the absolute amount of adipose tissue that confers risk for obesity-associated...
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Epigenetic programming for obesity and noncommunicable disease: From womb to tomb
Several epidemiological, clinical and experimental studies in recent decades have shown the relationship between exposure to stressors during...
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Effect of lifestyle and paternal feeding on the offspring’s metabolic programming
PurposeThis review was aimed at showing the importance of the father lifestyle on offspring phenotype. The focus was to highlight the father’s...
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Pesticides as endocrine disruptors: programming for obesity and diabetes
PurposeExposure to pesticides has been associated with obesity and diabetes in humans and experimental models mainly due to endocrine disruptor...
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Fetal programming and lactation: modulating gene expression in response to undernutrition during intrauterine life
BackgroundAdverse environmental conditions during intrauterine life, known as fetal programming, significantly contribute to the development of...
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Developmental Programming in Animal Models: Critical Evidence of Current Environmental Negative Changes
The Developmental Origins of Health and Disease (DOHaD) approach answers questions surrounding the early events suffered by the mother during...
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Metabolic abnormalities in the bone marrow cells of young offspring born to mothers with obesity
Background/ObjectivesIntrauterine metabolic reprogramming occurs in mothers with obesity during gestation, putting the offspring at high risk of...
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Metabolic and feeding adjustments during pregnancy
Eating behaviours are determined by the integration of interoceptive and environmental inputs. During pregnancy, numerous physiological adaptations...
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Metabolic diversity of tumor-infiltrating T cells as target for anti-immune therapeutics
Tumor-infiltrating T cells are promising drug targets to modulate the tumor microenvironment. However, tumor-infiltrating T lymphocytes, as central...
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Antenatal Programming of Hypertension: Paradigms, Paradoxes, and How We Move Forward
Purpose of ReviewSynthesize the clinical, epidemiological, and preclinical evidence for antenatal programming of hypertension and critically appraise...
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Metabolic and fecal microbial changes in adult fetal growth restricted mice
BackgroundFetal growth restriction (FGR) increases risk for development of obesity and type 2 diabetes. Using a mouse model of FGR, we tested whether...
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The metabolic consequences of HIV/TB co-infection
BackgroundThe synergy between the human immunodeficiency virus (HIV) and Mycobacterium tuberculosis during co-infection of a host is well known....
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Metabolic programming of nephron progenitor cell fate
Metabolic pathways are one of the first responses at the cellular level to maternal/fetal interface stressors. Studies have revealed the previously...
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BMI trajectory and inflammatory effects on metabolic syndrome in adolescents
BackgroundVarious life course factors can affect susceptibility to diseases during adolescence and adulthood, and those relationships are complex....
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The effect of foetal and early childhood growth on metabolic derangements of Sri Lankan children
BackgroundPrevious studies have shown that delayed prenatal growth followed by accelerated postnatal growth plays a significant role on the onset of...