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P4HA2 activates mTOR via hydroxylation and targeting P4HA2-mTOR inhibits lung adenocarcinoma cell growth
Mammalian target of rapamycin (mTOR) kinase functions as a central regulator of cell growth and metabolism, and its complexes mTORC1 and mTORC2...
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Kinase-independent role of mTOR and on-/off-target effects of an mTOR kinase inhibitor
mTOR, as a serine/threonine kinase, is a widely pursued anticancer target. Multiple clinical trials of mTOR kinase inhibitors are ongoing, but their...
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YAP inhibition overcomes adaptive resistance in HER2-positive gastric cancer treated with trastuzumab via the AKT/mTOR and ERK/mTOR axis
BackgroundHuman epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC) is a heterogeneous GC subtype characterized by the...
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mTOR eosinophilic renal cell carcinoma: a distinctive tumor characterized by mTOR mutation, loss of chromosome 1, cathepsin-K expression, and response to target therapy
In the spectrum of oncocytic renal neoplasms, a subset of tumors with high-grade-appearing histologic features harboring pathogenic mutations in...
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Duck Tembusu virus induces incomplete autophagy via the ERK/mTOR and AMPK/mTOR signalling pathways to promote viral replication in neuronal cells
Duck Tembusu virus (DTMUV) is a neurotropic virus in the genus Flavivirus that causes massive economic losses to the poultry industry in China and...
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Orf virus induces complete autophagy to promote viral replication via inhibition of AKT/mTOR and activation of the ERK1/2/mTOR signalling pathway in OFTu cells
Orf virus (ORFV) is the causative agent of contagious ecthyma, which is an important zoonotic pathogen with a widespread distribution affecting...
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Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease
The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular metabolism, catabolism, immune responses, autophagy, survival,...
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Treatment of tuberous sclerosis complex manifestations in children with mTOR inhibitors
PurposeTuberous sclerosis complex (TSC) is a rare autosomal dominant genetic disorder that affects multiple organ systems. Mutations in the TSC1 and...
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Mechanistic target of rapamycin (mTOR): a potential new therapeutic target for rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune disease characterized by systemic synovitis and bone destruction. Proinflammatory cytokines activate...
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mTOR signaling and endometrial receptivity in infertile women with intramural uterine leiomyomas
BackgroundReceptive endometrium is a restraining factor in the establishment of pregnancy in several estrogen-dependent gynecological disorders...
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Interleukin-22 Alleviates Caerulein-Induced Acute Pancreatitis by Activating AKT/mTOR Pathway
BackgroundAcute pancreatitis (AP) is one of the most common acute abdominal disorders; due to the lack of specific treatment, the treatment of acute...
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Malignant meningioma mTOR mutated and precision medicine
BackgroundWHO grade II and III meningiomas are more invasive than grade I malignancies and determine patients’ shorter overall survival. Their...
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Calcineurin and mTOR inhibitors in kidney transplantation: integrative metamodeling on transplant survival and kidney function
In our study, we examined the efficacy of mTOR (mammalian target of rapamycin) inhibitors, specifically rapamycin (Rap), compared to calcineurin...
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Mutated ASXL1 upregulates mTOR expression in renal cell carcinoma with fibromyomatous stroma
Renal cell carcinoma with fibromyomatous stroma (RCC FMS), defined as an “emerging entity” in the 2016 WHO classification and recommended to be a...
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OTUD7B knockdown inhibits proliferation and autophagy through AKT/mTOR signaling pathway in human prostate cancer cell
Prostate cancer (PCa) is the second leading disease of cancer-related death in men around the world, and it is almost impossible to treat advanced...
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mTOR mutation disrupts larval zebrafish tail fin regeneration via regulating proliferation of blastema cells and mitochondrial functions
BackgroundThe larval zebrafish tail fin can completely regenerate in 3 days post amputation. mTOR , the main regulator of cell growth and metabolism,...
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FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression
FRMD6, a member of the 4.1 ezrin-radixin-moesin domain-containing protein family, has been reported to inhibit tumor progression in multiple cancers....
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Low-level laser therapy alleviates periodontal age-related inflammation in diabetic mice via the GLUT1/mTOR pathway
Diabetes mellitus (DM) is a chronic age-related disease that was recently found as a secondary aging pattern regulated by the senescence associated...
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TNFα-dependent mTOR activity is required for tenotomy-induced ectopic ossification in mice
IntroductionEctopic ossifications often occur in skeletal muscles or tendons following local trauma or internal hemorrhage, and occasionally cause...
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RPN1 promotes the proliferation and invasion of breast cancer cells by activating the PI3K/AKT/mTOR signaling pathway
Ribophorin I (RPN1), a part of an N-oligosaccharyl-transferase complex, plays a vital role in the development of multiple cancers. However, its...
