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Real-World Evidence on Levetiracetam-Induced Hypokalemia: An Active Comparator Cohort Study
BackgroundLevetiracetam is an anti-seizure medication (ASM) with an established safety profile. However, a potential safety signal of hypokalemia...
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Levetiracetam Interaction with Direct Oral Anticoagulants: A Pharmacovigilance Study
BackgroundLevetiracetam is widely used in post-stroke epilepsy. However, it is suspected to possess P-glycoprotein (P-gp) induction properties, and...
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Levetiracetam versus Phenobarbitone for Management of Neonatal Seizures: A Systematic Review and Meta-analysis
ObjectivesTo review whether levetiracetam is non-inferior to phenobarbitone as the first-choice antiseizure medication (ASM).
MethodsThe authors...
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A case of glossopharyngeal neuralgia successfully treated with levetiracetam
BackgroundGlossopharyngeal neuralgia is a condition that causes severe pain in the throat during swallowing. Although carbamazepine is a viable...
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Effect of Levetiracetam on Cognition: A Systematic Review and Meta-analysis of Double-Blind Randomized Placebo-Controlled Trials
BackgroundStudies have suggested that levetiracetam may help improve cognitive function in patients with epilepsy. Recently, its efficacy in...
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Efficacy and Safety of Levetiracetam on the Treatment of Spasticity in Neurologic Disorders: a Systematic Review
Spasticity is one of the disabling complications of various neurologic disorders. Its relief through available pharmacotherapy is oftentimes...
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Enhanced renal clearance impacts levetiracetam concentrations in patients with traumatic brain injury with and without augmented renal clearance
BackgroundThe purpose of this study was to examine the impact of ARC on levetiracetam concentrations during the first week following acute TBI. The...
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Effects of sodium valproate and levetiracetam on posterior segment parameters in children with epilepsy
PurposeTo evaluate changes in posterior segment parameters in pediatric patients with epilepsy using sodium valproate or levetiracetam monotherapy...
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Evaluation of Levetiracetam Dosing Strategies for Seizure Prophylaxis Following Traumatic Brain Injury
BackgroundAlthough levetiracetam has been increasingly used as an alternative to phenytoin for early posttraumatic seizure prophylaxis following...
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Levetiracetam for the treatment of mild cognitive impairment in Parkinson’s disease: a double-blind controlled proof-of-concept trial protocol
BackgroundMild memory impairment, termed amnestic mild cognitive impairment (aMCI), is associated with rapid progression towards dementia in...
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Application of Physiologically Based Pharmacokinetic Modeling to Characterize the Effects of Age and Obesity on the Disposition of Levetiracetam in the Pediatric Population
BackgroundLevetiracetam is an antiseizure medication used for several seizure types in adults and children aged 1 month and older; however, due to a...
