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Serum soluble alpha-klotho klotho and cognitive functioning in older adults aged 60 and 79: an analysis of cross-sectional data of the National Health and Nutrition Examination Survey 2011 to 2014
ObjectivesKlotho, consisting of membrane klotho and soluble alpha-klotho, is found to be associated with better cognitive outcomes in small samples...
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FGF23 and klotho at the intersection of kidney and cardiovascular disease
Cardiovascular disease is the leading cause of death in patients with chronic kidney disease (CKD). As CKD progresses, CKD-specific risk factors,...
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The interaction between klotho protein and epigenetic alteration in diabetes and treatment options
IntroductionKlotho is a membrane protein predominantly expressed in the kidneys, and its discovery was serendipitously made through gene-targeting...
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Revealing the tumor suppressive sequence within KL1 domain of the hormone Klotho
Klotho, a 1012 amino acid transmembrane protein, is a potent tumor suppressor in different cancer types. Klotho is composed of two internal repeats...
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Lower serum Klotho level and higher systemic immune-inflammation index: an inverse correlation
ObjectivesKlotho, an anti-aging protein, has been identified to control tissue inflammatory responses. The objective of this research is to determine...
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Relationships of serum FGF23 and α-klotho with atherosclerosis in patients with type 2 diabetes mellitus
BackgroundCompelling evidence suggests that calcium/phosphorus homeostasis-related parameters may be linked to diabetes mellitus and cardiovascular...
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Relationship of Klotho with cognition and dementia: Results from the NHANES 2011–2014 and Mendelian randomization study
The relationships of Klotho levels with cognition and dementia are poorly understood. This study aimed to investigate the association between Klotho...
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Serum klotho levels and mortality patterns in frail individuals: unraveling the u-shaped association
BackgroundFrailty, a clinical syndrome intricately linked with the aging process, stands as a harbinger of numerous adverse outcomes, most notably...
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Serum soluble α-Klotho levels in patients with diabetic nephropathy
Abstract BackgroundThe study aimed to determine the variability in the stages of diabetic nephropathy by examining specific biochemical functions...
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The relationship between klotho, testosterone, and sexual health parameters among US adult men
BackgroundKlotho is a pleotropic hormone involved in a multitude of biological processes necessary for healthy aging, and affords protection from...
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Effects of Klotho protein, vitamin D, and oxidative stress parameters on urinary stone formation and recurrence
PurposeThe present study aimed to investigate the effects of α-Klotho and oxidative stress markers on urinary stone disease (USD) and demonstrate...
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Hypermethylation of Klotho and Peroxisome Proliferator-Activated Receptor γ Concomitant with Overexpression of DNA Methyltransferase 1 in Adenomyosis
Cellular senescence is known to be involved in tissue repair, but its role in adenomyosis remains unclear. This study was tasked to evaluate the...
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Improving sleep quality is essential for enhancing soluble Klotho levels in hemodialysis patients
PurposeSleep and Klotho seem to share common physiological pathways in aging. However, studies investigating this relationship are very few and none...
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Association of serum soluble α‑klotho with risk of kidney stone disease: a population-based cross-sectional study
BackgroundThe aim of the study was to explore the association of serum soluble klotho with kidney stone disease (KSD) in the general population over...
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Analysis of the correlation between serum Klotho and FeNO: a cross-sectional study from NHANES (2007–2012)
BackgroundKlotho is an anti-aging protein that has multiple functions and may play a key role in the pathogenesis and progression of chronic...
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Klotho enhances bone regenerative function of hPDLSCs via modulating immunoregulatory function and cell autophagy
BackgroundHuman periodontal ligament stem cells (hPDLSCs) have a superior ability to promote the formation of new bones and achieve tissue...
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Association between anemia and serum Klotho in middle-aged and older adults
BackgroundThe role of Klotho as a multifunctional protein in anemia is unclear. This study aimed to determine the association between anemia and...
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A prospective study of the association between serum klotho and mortality among adults with rheumatoid arthritis in the USA
BackgroundWhile it is known that klotho has negative regulatory effects in a variety of diseases such as metabolic disorders and kidney disease, the...
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U-shaped association between serum Klotho and accelerated aging among the middle-aged and elderly US population: a cross-sectional study
BackgroundPhenotypic age acceleration, which reflects the difference between phenotypic age and chronological age, is an assessment to measure...
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The association of serum Klotho concentrations with hyperlipidemia prevalence and lipid levels among US adults: a cross-sectional study
BackgroundKlotho has anti-oxidative and anti-inflammatory properties. However, little is known about whether high Klotho concentrations were...
