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Utility of anti-immunoglobulin IgA, IgG, IgM, Kappa, Lambda - FITC (conjugate) cocktail in routine renal pathology practice
BackgroundImmunofluorescence studies on frozen sections are an essential component in the evaluation of renal biopsies. The basic panel in most...
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The clinicopathological characteristics and outcomes of IgA nephropathy with predominant lambda or kappa light-chain deposition
PurposeIgA nephropathy (IgAN) patients with monoclonal light-chain deposition may be at potential risk of hematological progression. However, whether...
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The presence of two light chain bands on immunofixation is associated with poor outcomes in newly diagnosed multiple myeloma patients
We aimed to describe the clinical and biological characteristics and the prognosis of patients presenting with an additional light chain (LC) band...
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Spectrum of renal involvement in MGRS patients: a 6-year study
Background and objectivesMonoclonal gammopathy of renal significance (MGRS) includes smoldering B cell or plasma cell clones causing renal disease....
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A low BUN/creatinine ratio predicts histologically confirmed acute interstitial nephritis
IntroductionIn hospitalized patients with acute renal injury (AKI), acute tubulointerstitial nephritis (AIN) constitutes one of the leading...
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Phenotypes and outcome of diffuse pulmonary non-amyloid light chain deposition disease
BackgroundLight chain deposition disease (LCDD) is a very rare entity. Clinical manifestations of LCDD vary according to the organs involved. Data on...
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A case of solitary plasmacytoma of bone showing co-expression of both immunoglobulin light chains
BackgroundSolitary plasmacytoma of bone (SPB) is a rare plasma cell neoplasm. It arises in bone as a single locus in the absence of any plasma cell...
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LMS-based continuous pediatric reference values for soluble receptor activator of nuclear factor kappa B ligand (sRANKL) and osteoprotegerin (OPG) in the HARP cohort
SummarySoluble RANKL (sRANKL) and osteoprotegerin (OPG) are regulators of osteoclast differentiation and activation, but adequate pediatric reference...
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Medium cut-off dialyzer for middle molecular uremic toxins in AKI and chronic dialysis
Uremic toxins accumulate in patients affected by renal failure and can deposit in different organs, including the kidneys and heart. Given their...
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Estimating the COVID-19 infection fatality ratio accounting for seroreversion using statistical modelling
BackgroundThe infection fatality ratio (IFR) is a key statistic for estimating the burden of coronavirus disease 2019 (COVID-19) and has been...
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Clinicopathological significance of light chain deposition in IgA nephropathy
BackgroundClinicopathological significance of light chain deposition in IgA nephropathy and the relation of monotypic IgA deposition to bone marrow...
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Lambda light chain-induced monoclonal gammopathy of renal significance, manifesting with Fanconi Syndrome and osteomalacia
BackgroundMonoclonal gammopathy of renal significance (MGRS) encompasses a heterogeneous group of kidney diseases in which a monoclonal...
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A Comparative Analysis of Freelite and N Latex FLC Assay for the sFLC Measurements in Suspected Patients of Monoclonal Gammopathy
With the introduction of newer platforms for sFLC estimation, more comparative attempts are required to establish an assay-specific reference range,...
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Cord Blood Proteomic Biomarkers for Predicting Adverse Neurodevelopmental Outcomes in Monoamniotic Twins
Monoamniotic twins have a high risk of mortality and perinatal morbidity due to cord entanglement and vascular anastomosis. Despite efforts to reduce...
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Systematic review and meta-analysis of the clinical features of MGRS
BackgroundIt is crucial to identify patients with monoclonal gammopathy of renal significance (MGRS) from those without MGRS but with monoclonal...
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Hemodiafiltration with ultrafiltrate regeneration reduces free light chains without albumin loss in multiple myeloma patients
BackgroundAcute kidney injury (AKI) occurs in 12–20% of multiple myeloma (MM) patients. Several studies have shown a reduction of free light chains...
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B cell receptor repertoire analysis in primary Sjogren’s syndrome salivary glands identifies repertoire features associated with clinical activity
BackgroundPrimary Sjogren’s syndrome (pSS) is a complex autoimmune disease featuring damage to salivary and lacrimal glands, with the possibility of...
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A case of systemic sarcoidosis with mesangial proliferative glomerulonephritis showing predominant deposition of IgG in the mesangial region
A 37-year-old African–British man was referred to our hospital for detailed examination because of persistent fever, swelling and pain in both ankle...
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Atypical anti-glomerular basement membrane glomerulonephritis in a patient with metastatic melanoma treated with mitogen-activated protein kinase and immune checkpoint inhibitors: a case report
BackgroundImmune checkpoint inhibitors and mitogen-activated protein kinase inhibitors have become the standard of care in patients with advanced...
