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The contribution of imprinted genes to neurodevelopmental and neuropsychiatric disorders
Imprinted genes are a subset of mammalian genes that are subject to germline parent-specific epigenetic modifications leading monoallelic expression....
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Mature and immature ovarian teratomas share methylation profiles of imprinted genes: a MS-MLPA analysis
Immature teratomas are a subset of ovarian teratomas, and the pathogenic relationship between mature and immature ovarian teratomas is unclear....
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Poor semen parameters are associated with abnormal methylation of imprinted genes in sperm DNA
BackgroundAltered sperm DNA methylation patterns of imprinted genes as well as certain spermatogenesis-related genes has been proposed as a possible...
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Sperm DNA integrity status is associated with DNA methylation signatures of imprinted genes and non-imprinted genes
PurposeTo evaluate the association between the DNA methylation of specific genes and sperm DNA integrity status in human sperm samples.
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Dynamic single-cell map** unveils Epstein‒Barr virus-imprinted T-cell exhaustion and on-treatment response
Epstein‒Barr virus (EBV)-associated gastric cancer (GC) manifests an intriguing immunotherapy response. However, the cellular basis for EBV-imprinted...
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Deregulation of imprinted genes expression and epigenetic regulators in placental tissue from intrauterine growth restriction
PurposeIntrauterine growth restriction (IUGR) is a fetal growth complication that can be caused by ineffective nutrient transfer from the mother to...
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Exosomal microRNAs in the DLK1-DIO3 imprinted region derived from cancer-associated fibroblasts promote progression of hepatocellular carcinoma by targeting hedgehog interacting protein
BackgroundHepatocellular carcinoma (HCC) is the sixth most commonly diagnosed cancer and third leading cause of cancer-related death worldwide in...
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Expression and DNA Methylation Status of the Imprinted Genes PEG10 and L3MBTL1 in the Umbilical Cord Blood and Placenta of the Offspring of Assisted Reproductive Technology
The aim of this study is to investigate the expression and DNA methylation status of the imprinted genes PEG10 and L3MBTL1 in the offspring of...
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Methylation profiles of imprinted genes are distinct between mature ovarian teratoma, complete hydatidiform mole, and extragonadal mature teratoma
Mature ovarian teratoma is considered to be a parthenogenetic tumor that arises from a single oocyte/ovum. Conversely, complete hydatidiform mole...
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Profiling the DNA methylation patterns of imprinted genes in abnormal semen samples by next-generation bisulfite sequencing
PurposeChanges in DNA methylation modifications have been associated with male infertility. With the development of assisted reproductive...
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Mouse oocyte vitrification with and without dimethyl sulfoxide: influence on cryo-survival, development, and maternal imprinted gene expression
PurposeOocytes and embryos can be vitrified with and without dimethyl sulfoxide (DMSO). Objectives were to compare no vitrification (No-Vitr),...
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Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification
Pediatric central nervous system (CNS) tumors represent the most common cause of cancer-related death in children aged 0–14 years. They differ from...
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Imprinting disorders
Imprinting disorders (ImpDis) are congenital conditions that are characterized by disturbances of genomic imprinting. The most common individual...
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Identification and validation of core genes for type 2 diabetes mellitus by integrated analysis of single-cell and bulk RNA-sequencing
BackgroundThe exact mechanisms of type 2 diabetes mellitus (T2DM) remain largely unknown. We intended to authenticate critical genes linked to T2DM...
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Integrative analysis revealed a correlation of PIAS family genes expression with prognosis, immunomodulation and chemotherapy
BackgroundProtein inhibitor of activated STATs (PIAS) has pleiotropic biological effects, such as protein post-translational modification,...
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Novel epigenetic molecular therapies for imprinting disorders
Genomic imprinting disorders are caused by the disruption of genomic imprinting processes leading to a deficit or increase of an active allele. Their...
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Immediate and durable effects of maternal tobacco consumption alter placental DNA methylation in enhancer and imprinted gene-containing regions
BackgroundAlthough exposure to cigarette smoking during pregnancy has been associated with alterations of DNA methylation in the cord blood or...
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Epigenetic genes and epilepsy — emerging mechanisms and clinical applications
An increasing number of epilepsies are being attributed to variants in genes with epigenetic functions. The products of these genes include factors...
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Intrinsically dysregulated cellular stress signaling genes and gene networks in postpartum depression
Postpartum depression (PPD) is a leading cause of morbidity and mortality among women. Clinically, the administration and withdrawal of...
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Loss of the Maternal Effect Gene Nlrp2 Alters the Transcriptome of Ovulated Mouse Oocytes and Impacts Expression of Histone Demethylase KDM1B
The subcortical maternal complex (SCMC) is a multiprotein complex in oocytes and preimplantation embryos that is encoded by maternal effect genes....
