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Management of Dysregulated Immune Response in the Critically Ill
This book, part of the European Society of Intensive Care Medicine (ESICM) textbook series, deals with dysregulated host response a relatively new...
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mRNA vaccine boosters and impaired immune system response in immune compromised individuals: a narrative review
Over the last 24 months, there has been growing evidence of a correlation between mRNA COVID-19 vaccine boosters and increased prevalence of COVID-19...
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Effect of radiochemotherapy on peripheral immune response in glioblastoma
BackgroundGlioblastoma (GBM) is a primary brain tumor with a dismal prognosis, often resistant to immunotherapy and associated with immune...
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PIK3CA mutation-driven immune signature as a prognostic marker for evaluating the tumor immune microenvironment and therapeutic response in breast cancer
PurposeGene mutations drive tumor immune microenvironment (TIME) heterogeneity, in turn affecting prognosis and immunotherapy efficacy. PIK3CA is the...
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Characterizing the immune response to myocardial infarction in pigs
Though myocardial infarction (MI) in pigs is a well-established translational large animal model, it has not yet been widely used for immunotherapy...
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Comprehensive molecular analyses of cuproptosis-related genes with regard to prognosis, immune landscape, and response to immune checkpoint blockers in lung adenocarcinoma
BackgroundRecent studies have emphasized the importance of the biological processes of different forms of cell death in tumor heterogeneity and...
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Immune landscape and response to oncolytic virus-based immunotherapy
Oncolytic virus (OV)-based immunotherapy has emerged as a promising strategy for cancer treatment, offering a unique potential to selectively target...
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DNA Methylation Signatures Correlate with Response to Immune Checkpoint Inhibitors in Metastatic Melanoma
BackgroundDNA methylation profiles have emerged as potential predictors of therapeutic response in various solid tumors.
ObjectiveThis study aimed...
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Crosstalk between immune checkpoint and DNA damage response inhibitors for radiosensitization of tumors
PurposeThis review article is intended to provide a perspective overview of potential strategies to overcome radiation resistance of tumors through...
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Immune response after SARS-CoV-2 vaccination in patients with inflammatory immune-mediated diseases receiving immunosuppressive treatment
BackgroundReal world data on the response to the SARS-CoV-2 vaccine in patients with immunomediated diseases (IMIDs) treated with immunesuppressants...
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Higher inflammatory response in hepatocellular carcinoma is associated with immune cell infiltration and a better outcome
Background and aimsHepatocellular carcinoma (HCC) often develops from chronic liver inflammation. Inflammation within a tumor can either promote...
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Cancer-associated fibroblasts: heterogeneity and their role in the tumor immune response
In recent decades, many reports have been published on the composition and function of the tumor microenvironment (TME), among which...
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Temperature impacts the bovine ex vivo immune response towards Mycoplasmopsis bovis
Although cattle are the mammalian species with most global biomass associated with a huge impact on our planet, their immune system remains poorly...
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Tumor characteristics of dissociated response to immune checkpoint inhibition in advanced melanoma
IntroductionImmune checkpoint inhibition (ICI) has improved patients’ outcomes in advanced melanoma, often resulting in durable response. However,...
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An immune-related exosome signature predicts the prognosis and immunotherapy response in ovarian cancer
BackgroundCancer-derived exosomes contribute significantly in intracellular communication, particularly during tumorigenesis. Here, we aimed to...
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Systemic Immune-Inflammation Response is Associated with Futile Recanalization After Endovascular Treatment
BackgroundFrequent incidence of futile recanalization decreases the benefit of endovascular treatment (EVT) in acute ischemic stroke. We hypothesized...
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Pan-cancer evaluation of regulated cell death to predict overall survival and immune checkpoint inhibitor response
Regulated cell death (RCD) plays a pivotal role in various biological processes, including development, tissue homeostasis, and immune response....
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Airway and Systemic Immunoglobulin Profiling and Immune Response in Adult Asthma
IntroductionImmunoglobulins play a vital role in host immune response and in the pathogenesis of conditions like asthma. Therapeutic agents such as...
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Comprehensive analysis and identification of subtypes and hub genes of high immune response in lung adenocarcinoma
BackgroundThe advent of immunotherapy targeting immune checkpoints has conferred significant clinical advantages to patients with lung adenocarcinoma...
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NF1 mutations as biomarker of response to immune checkpoint blockades for lung adenocarcinoma patients
Little is known about immune checkpoint inhibitors (ICI) response of NF1 -mutated lung adenocarcinomas. 341/4,181 (8.2%) TCGA lung adenocarcinomas...
