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Myasthenia gravis concurrent with Parkinson’s disease in a Spanish cohort. Causation or correlation?
BackgroundComorbidity between myasthenia gravis (MG) and other autoimmune diseases is well-documented. However, concurrent MG and Parkinson’s disease...
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Parkinson’s disease and COVID-19: a systematic review and meta-analysis
BackgroundPatients with Parkinson’s disease (PD) are at higher risk of COVID-19 infection as most of them are at older age. The goal of this study...
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Research process, recap, and prediction of Chiari malformation based on bicentennial history of nomenclature and terms misuse
There is an absent systematic analysis or review that has been conducted to clarify the topic of nomenclature history and terms misuse about Chiari...
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The effects of exercise dose on patients with Parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials
ObjectiveThe effects of different exercise doses on motor function, balance, mobility, and quality of life (QOL) in patients with Parkinson's disease...
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A brief history of brain iron accumulation in Parkinson disease and related disorders
Iron has a long and storied history in Parkinson disease and related disorders. This essential micronutrient is critical for normal brain function,...
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Pallidal degenerations and related disorders: an update
Neurodegenerative disorders involving preferentially the globus pallidus, its efferet and afferent circuits and/or related neuronal systems are rare....
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Parkinson's disease — the story of an eponym
One of the most prevalent neurodegenerative diseases worldwide is still referred to as 'Parkinson's disease'. The condition is named after James...
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Lack of association between appendectomy and Parkinson’s disease: a systematic review and meta-analysis
BackgroundAccumulation of aggregated α-synuclein from the enteric nervous system is believed to be involved in the pathogenesis of Parkinson’s...
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Botanical Therapeutics for Parkinson’s Disease
Parkinson’s disease (PD) was first formally described by James Parkinson in 1817, but the shaking of limbs was described in the literature of several...
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Deep representation learning of electronic health records to unlock patient stratification at scale
Deriving disease subtypes from electronic health records (EHRs) can guide next-generation personalized medicine. However, challenges in summarizing...
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Hand, foot, and spine deformities in parkinsonian disorders
Hand and foot deformities, known as “striatal deformities”, and other musculoskeletal abnormalities such as dropped head, bent spine, camptocormia,...
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Rules of Meridians and Acupoints Selection in Treatment of Parkinson's Disease Based on Data Mining Techniques
ObjectiveTo help selecting appropriate meridians and acupoints in clinical practice and experimental study for Parkinson's disease (PD), the rules of...
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Increased risk of diseases of the basal ganglia and cerebellum in patients with a history of attention-deficit/hyperactivity disorder
Attention-deficit/hyperactivity disorder (ADHD) is marked by an ongoing pattern of inattention and/or hyperactivity and involves dysregulated...
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Chinese medicine for idiopathic Parkinson’s disease: A meta analysis of randomized controlled trials
ObjectiveTo evaluate the efficacy of Chinese medicine (CM) adjunct to conventional medications for idiopathic Parkinson’s disease (PD).
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Paraquat and Parkinson’s disease: a systematic review protocol according to the OHAT approach for hazard identification
BackgroundParkinson’s disease (PD) is a progressive neurodegenerative condition that has genetic susceptibility, aging, and exposure to certain...
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Meta-analysis on the prevalence of REM sleep behavior disorder symptoms in Parkinson’s disease
BackgroundOur study was aimed to evaluate the risk of a selected non-motor symptom, namely rapid eye movement behavior disorder (RBD) symptoms, among...
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The efficacy and safety of coenzyme Q10 in Parkinson’s disease: a meta-analysis of randomized controlled trials
The objective of this meta-analysis was to evaluate the effects of coenzyme Q10 (CoQ10) for the treatment of Parkinson’s disease (PD) patients in...
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Sleep/wake problems in Parkinson’s disease: pathophysiology and clinicopathologic correlations
In his initial description of shaking palsy, James Parkinson first noted that sleep became disturbed with advancing paralysis agitans. More recent...
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Different diagnostic criteria for Parkinson disease: what are the pitfalls?
As there are no definite diagnostic tests or reliable biomarkers for Parkinson disease (PD), its diagnosis still relies on the presence of a...
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Biomarker candidates of neurodegeneration in Parkinson’s disease for the evaluation of disease-modifying therapeutics
Reliable biomarkers that can be used for early diagnosis and tracking disease progression are the cornerstone of the development of disease-modifying...