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Research Progress on Histone Deacetylases Regulating Programmed Cell Death in Atherosclerosis
AbstractHistone deacetylases (HDACs) are epigenetic modifying enzyme that is closely related to chromatin structure and gene transcription, and...
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Deficiency of histone deacetylases 3 in macrophage alleviates monosodium urate crystals-induced gouty inflammation in mice
BackgroundGout is caused by monosodium urate (MSU) crystals deposition to trigger immune response. A recent study suggested that inhibition of Class...
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Comprehensive gene expression analysis of histone deacetylases and the transcription factor Nrf2 in the progression of diabetic nephropathy
BackgroundNuclear factor erythroid-2-related factor 2 (Nrf2) is a crucial transcription factor in maintaining cellular homeostasis. The regulation of...
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Tryptophan metabolite norharman secreted by cultivated Lactobacillus attenuates acute pancreatitis as an antagonist of histone deacetylases
BackgroundPatients with acute pancreatitis (AP) exhibit specific phenotypes of gut microbiota associated with severity. Gut microbiota and host...
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The roles of histone deacetylases in kidney development and disease
Histone deacetylases (HDACs) are important epigenetic regulators that mediate deacetylation of both histone and non-histone proteins. HDACs,...
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Histone acetylation and the role of histone deacetylases in normal cyclic endometrium
Histone acetylation is a critical epigenetic modification that changes chromatin architecture and regulates gene expression by opening or closing the...
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Targeting histone modifiers in bladder cancer therapy — preclinical and clinical evidence
Bladder cancer in the most advanced, muscle-invasive stage is lethal, and very limited therapeutic advances have been reported for decades. To date,...
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Exploring the role of histone deacetylase and histone deacetylase inhibitors in the context of multiple myeloma: mechanisms, therapeutic implications, and future perspectives
Histone deacetylase inhibitors (HDACis) are a significant category of pharmaceuticals that have developed in the past two decades to treat multiple...
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Elevated histone deacetylase 10 expression promotes the progression of clear cell renal cell carcinoma by Notch-1-PTEN signaling axis
BackgroundClear cell renal cell carcinoma (ccRCC), the most common pathological subtype of kidney cancer, accounts for approximately 70% to 80% of...
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The prognosis and clinicopathological significance of histone deacetylase in hepatocellular carcinoma: a meta-analysis
The value of the different types of HDACs (histone deacetylases) for HCC (hepatocellular carcinoma) prognosis and clinicopathological features is...
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The role of histone modifications: from neurodevelopment to neurodiseases
Epigenetic regulatory mechanisms, including DNA methylation, histone modification, chromatin remodeling, and microRNA expression, play critical roles...
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Expression patterns and therapeutic implications of histone deacetylase-1 across carcinomas: a comprehensive molecular docking and MD simulation study
Histone deacetylases (HDACs) are a group of enzymes that control the expression of genes by deacetylating lysine residues on histone and nonhistone...
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Targeting phosphoinositide 3-kinases and histone deacetylases in multiple myeloma
BackgroundMultiple myeloma (MM) is a type of hematological malignancy affecting the functions of plasma cells. The treatment of MM patients has...
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Identification of histone acetyltransferase genes responsible for cannabinoid synthesis in hemp
BackgroundHistone acetyltransferases (HATs) play an important role in plant growth and development, stress response, and regulation of secondary...
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Repurposing of triamterene as a histone deacetylase inhibitor to overcome cisplatin resistance in lung cancer treatment
PurposeCisplatin is the core chemotherapeutic drug used for first-line treatment of advanced non-small cell lung cancer (NSCLC). However, drug...
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Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression
Histone deacetylase (HDAC) is a kind of protease that modifies histone to regulate gene expression, and is usually abnormally activated in tumors....
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A real-world pharmacovigilance study investigating the toxicities of histone deacetylase inhibitors
Histone deacetylase (HDAC) inhibitors are emerging as promising treatments for hematological malignancies, with potential applications extending to...
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Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage
IntroductionSelenium (Se) as well as selenoproteins are vital for osteochondral system development. Se deficiency (SeD) has a definite impact on the...
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The role of histone deacetylase 3 in breast cancer
It has been recently revealed that Histone Deacetylase (HDAC) 3, a unique member of the HDACs family, can trigger and progress cancers by alternation...
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STAT5 promotes PD-L1 expression by facilitating histone lactylation to drive immunosuppression in acute myeloid leukemia
Immunotherapy is a revolutionized therapeutic strategy for tumor treatment attributing to the rapid development of genomics and immunology, and...
