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Heme oxygenase 1 in erythropoiesis: an important regulator beyond catalyzing heme catabolism
Heme oxygenase 1 (HO-1), encoded by the HMOX-1 gene, is the main heme oxygenase that catalyzes the degradation of heme into iron, carbon monoxide,...
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Heme-Iron Optifer Versus Intravenous Iron/Ferosac in Treatment of Iron Efficiency Anemia During Pregnancy
To compare the efficacy and tolerability of heme-iron Optifer (HIO) versus intravenous (IV) iron saccharate/Ferosac in treatment of iron deficiency...
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Heme Oxygenase-1, Cardiac Senescence, and Myocardial Infarction: A Critical Review of the Triptych
PurposeHeme oxygenase-1 (HO-1) is a crucial enzyme in heme metabolism, facilitating the breakdown of heme into biliverdin, carbon monoxide, and free...
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Association between gastric cancer and the intake of different types of iron and meats
BackgroundHeme and non-heme irons are two forms of iron in the diet. Few studies have evaluated the association between heme iron intake and the risk...
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A role of splenic heme biosynthesis pathway in the persistent prophylactic actions of arketamine in lipopolysaccharide-treated mice
Relapse is common in remitted patients with major depressive disorder (MDD). Arketamine, an ( R )-enantiomer of ketamine, has persistent prophylactic...
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The dual role and mutual dependence of heme/HO-1/Bach1 axis in the carcinogenic and anti-carcinogenic intersection
IntroductionIn physiological concentrations, heme is nontoxic to the cell and is essential for cell survival and proliferation. Increasing...
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Heme as a differentiation-regulatory transcriptional cofactor
The hematopoietic transcription factor GATA1 induces heme accumulation during erythropoiesis by directly activating genes mediating heme...
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Dietary Iron Intake and New-Onset Hypertension: A Nationwide Cohort Study from China
ObjectivesThe relationship of dietary iron intake with the risk of hypertension remains uncertain. We aimed to investigate the prospective...
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Iron imbalance in neurodegeneration
Iron is an essential element for the development and functionality of the brain, and anomalies in its distribution and concentration in brain tissue...
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Myeloid cell iron uptake pathways and paramagnetic rim formation in multiple sclerosis
In multiple sclerosis (MS), sustained inflammatory activity can be visualized by iron-sensitive magnetic resonance imaging (MRI) at the edges of...
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Heme oxygenase-1 deficiency as an extremely rare cause of AA-type renal amyloidosis: Expanding the clinical features and review of the literature
Heme oxygenase-1 (HMOX-1) is an enzyme that regulates heme degradation. Antiinflammatory, antioxidant, and cytoprotective effects of HMOX-1 were also...
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Heme-regulated inhibitor: an overlooked eIF2α kinase in cancer investigations
Heme-regulated inhibitor (HRI) kinase is a serine–threonine kinase, controlling the initiation of protein synthesis via phosphorylating α subunit of...
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Haem iron versus ferrous iron salts to treat iron deficiency anaemia in Gambian children: protocol for randomised controlled trial {1}
BackgroundThe World Health Organization recommends universal iron supplementation for children aged 6–23 months in countries where anaemia is seen in...
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Iron as an emerging therapeutic target in critically ill patients
The multiple roles of iron in the body have been known for decades, particularly its involvement in iron overload diseases such as hemochromatosis....
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Targeting iron metabolism in osteosarcoma
Osteosarcoma (OS) is the most common primary solid malignant tumour of bone, with rapid progression and a very poor prognosis. Iron is an essential...
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Molecular insights into placental iron transfer mechanisms and maternofetal regulation
PurposeAdequate iron transportation from the mother across the placenta is crucial for fetal growth and establishing sufficient iron stores in...
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Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure
The progression of heart failure (HF) is complex and involves multiple regulatory pathways. Iron ions play a crucial supportive role as a cofactor...
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The influence of iron on bone metabolism disorders
Iron is a necessary trace element in the human body, and it participates in many physiological processes. Disorders of iron metabolism can cause...
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Heart Failure-Related Iron Deficiency Anemia Pathophysiology and Laboratory Diagnosis
Purpose of ReviewThe goal of the current review is to give an overview regarding the pathophysiology of iron deficiency in heart failure and how...
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Iron and iron-related proteins in COVID-19
COVID-19 can cause detrimental effects on health. Vaccines have helped in reducing disease severity and transmission but their long-term effects on...
