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Reactive glia-to-GABAergic neuron reprogramming: a “golden touch” strategy to alleviate intractable seizures
This commentary highlights a research article published recently in Cell Stem Cell “Reprogramming reactive glia into interneurons reduces chronic...
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Human brain organoid model of maternal immune activation identifies radial glia cells as selectively vulnerable
Maternal immune activation (MIA) during critical windows of gestation is correlated with long-term neurodevelopmental deficits in the offspring,...
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Neonatal loss of FGFR2 in astroglial cells affects locomotion, sociability, working memory, and glia-neuron interactions in mice
Fibroblast growth factor receptor 2 (FGFR2) is almost exclusively expressed in glial cells in postnatal mouse brain, but its impact in glia for brain...
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Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia by a novel mutation of the CSF1R gene
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a rare autosomal dominant disorder caused by mutations in the...
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Dorsal vagal complex and hypothalamic glia differentially respond to leptin and energy balance dysregulation
Previous studies identify a role for hypothalamic glia in energy balance regulation; however, a narrow hypothalamic focus provides an incomplete...
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NG2 glia regulate brain innate immunity via TGF-β2/TGFBR2 axis
BackgroundBrain innate immunity is vital for maintaining normal brain functions. Immune homeostatic imbalances play pivotal roles in the pathogenesis...
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Therapeutic hypothermia modulates the neurogenic response of the newborn piglet subventricular zone after hypoxia-ischemia
BackgroundNeuroprotection combined with neuroregeneration may be critical for optimizing functional recovery in neonatal encephalopathy. To...
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Characterisation of premature cell senescence in Alzheimer’s disease using single nuclear transcriptomics
Aging is associated with cell senescence and is the major risk factor for AD. We characterized premature cell senescence in postmortem brains from...
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Prioritizing evidence-based practices for acute respiratory distress syndrome using digital data: an iterative multi-stakeholder process
BackgroundEvidence-based practices (EBPs) for patients receiving invasive mechanical ventilation vary in the quality of their underlying evidence and...
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Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [11C]SMW139 and [18F]F-DPA
BackgroundP2X7 receptor has emerged as a potentially superior PET imaging marker to TSPO, the gold standard for imaging glial reactivity. [ 11 C]SMW139...
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Neuroimmunology of Cardiovascular Disease
Purpose of ReviewCardiovascular disease (CVD) is a leading cause of death and chronic disability worldwide. Yet, despite extensive intervention...
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Lymphocytic choriomeningitis virus injures the develo** brain: effects and mechanisms
AbstractLymphocytic choriomeningitis virus (LCMV) is a prevalent pathogen, whose natural host and reservoir is the wild mouse. Humans can be infected...
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Brain stars take the lead during critical periods of early postnatal brain development: relevance of astrocytes in health and mental disorders
In the brain, astrocytes regulate shape and functions of the synaptic and vascular compartments through a variety of released factors and...
