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Trans-ancestry meta-analysis of genome wide association studies of inhibitory control
Deficits in effective executive function, including inhibitory control are associated with risk for a number of psychiatric disorders and...
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Impact of polygenic score for BMI on weight loss effectiveness and genome-wide association analysis
BackgroundWhile environmental factors play an important role in weight loss effectiveness, genetics may also influence its success. We examined...
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Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population
While 1–2% of individuals meet the criteria for a clinical diagnosis of obsessive-compulsive disorder (OCD), many more (~13–38%) experience...
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Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies
Genome-wide association studies (GWAS) provide biological insights into disease onset and progression and have potential to produce clinically useful...
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Genome-wide association study in 404,302 individuals identifies 7 significant loci for reaction time variability
Reaction time variability (RTV), reflecting fluctuations in response time on cognitive tasks, has been proposed as an endophenotype for many...
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Genome-wide association study implicates lipid pathway dysfunction in antipsychotic-induced weight gain: multi-ancestry validation
Antipsychotic-induced weight gain (AIWG) is a common side effect of antipsychotic medication and may contribute to diabetes and coronary heart...
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Genome-wide association study of nausea and vomiting during pregnancy in Japan: the TMM BirThree Cohort Study
BackgroundNausea and vomiting during pregnancy (NVP) and hyperemesis gravidarum (HG), common conditions affecting most pregnant women, are highly...
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Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations
Coffee is one of the most widely consumed beverages. We performed a genome-wide association study ( GWAS ) of coffee intake in US-based 23andMe...
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A sex-specific genome-wide association study of depression phenotypes in UK Biobank
There are marked sex differences in the prevalence, phenotypic presentation and treatment response for major depression. While genome-wide...
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Meta-analysis of genome-wide association studies of hoarding symptoms in 27,651 individuals
Hoarding Disorder (HD) is a mental disorder characterized by persistent difficulties discarding or parting with possessions, often resulting in...
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Exome sequencing and genome-wide association analyses unveils the genetic predisposition in hydroxychloroquine retinopathy
ObjectivesTo unveil the candidate susceptibility genes in chloroquine/hydroxychloroquine (CQ/HCQ) retinopathy using whole exome sequencing (WES) and...
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Identifying novel proteins for suicide attempt by integrating proteomes from brain and blood with genome-wide association data
Genome-wide association studies (GWASs) have identified risk loci for suicide attempt (SA), but deciphering how they confer risk for SA remains...
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The largest genome-wide association study for breast cancer in Taiwanese Han population
PurposeBreast cancer is a molecularly heterogeneous disease, and multiple genetic variants contribute to its development and prognosis. Most of...
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A genome-wide association study identifies 25(OH)D3-associated genetic variants in the prediabetic Chinese population
ObjectivesDiabetes mellitus has been a significant public health problem, associated with high rates of morbidity, disability, and mortality....
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Genome-wide association study identified six loci associated with adverse drug reactions to aripiprazole in schizophrenia patients
Aripiprazole is recommended for routine use in schizophrenia patients. However, the biological mechanism for the adverse drug reactions (ADRs) among...
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Loneliness and depression: bidirectional mendelian randomization analyses using data from three large genome-wide association studies
Major depression (MD) is a serious psychiatric illness afflicting nearly 5% of the world’s population. A large correlational literature suggests that...
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Genome-wide association study (GWAS) identified PCOS susceptibility variants and replicates reported risk variants
BackgroundGenetic predisposition and environmental factors are considered risk factors for polycystic ovary syndrome (PCOS). Genome-wide association...
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Integrating plasma proteomes with genome-wide association data for causal protein identification in multiple myeloma
BackgroundMultiple myeloma (MM) is a severely debilitating and fatal B-cell neoplastic disease. The discovery of disease-associated proteins with...
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Genome-wide association study of traumatic brain injury in U.S. military veterans enrolled in the VA million veteran program
Large-scale genetic studies of traumatic brain injury (TBI) are lacking; thus, our understanding of the influence of genetic factors on TBI risk and...
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A longitudinal genome-wide association study of bone mineral density mean and variability in the UK Biobank
SummaryBone mineral density (BMD) is an essential predictor of osteoporosis and fracture. We conducted a genome-wide trajectory analysis of BMD and...
