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Metabolic profiling of galectin-1 and galectin-3: a cross-sectional, multi-omics, association study
ObjectivesExperimental studies indicate a role for galectin-1 and galectin-3 in metabolic disease, but clinical evidence from larger populations is...
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Emerging Roles of Galectin-3 in Pulmonary Diseases
Galectin-3 is a multifunctional protein that is involved in various physiological and pathological events. Emerging evidence suggests that galectin-3...
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Galectin-3 levels in children with cystic fibrosis
Cystic fibrosis (CF) is a multisystemic disease in which airway obstruction, infection, and inflammation play a critical role in the pathogenesis and...
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Association between sleep patterns and galectin-3 in a Chinese community population
BackgroundIrregular sleep patterns have been associated with inflammation. Galectin-3, a novel biomarker, plays an important role in inflammation. We...
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Galectin-3: action and clinical utility in chronic kidney disease
Chronic kidney disease is a significant cause of morbidity and mortality worldwide. In recent years, Galectin-3 has been put forward as a potential...
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Role of Galectin-3 in intervertebral disc degeneration: an experimental study
BackgroundThis study investigated the role of Galectin-3 in the degeneration of intervertebral disc cartilage.
MethodsThe patients who underwent...
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Relationship between galectin-3 level and disease activity in ankylosing spondylitis patients
Background and aimsAnkylosing spondylitis (AS) is a chronic inflammatory disease that chiefly affects the sacroiliac joints and the spine....
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Galectin-3, a damage-associated molecular pattern, in tears of patients with vernal keratoconjunctivitis
PurposeGalectin-3 is a damage-associated molecular pattern (DAMPs), released from damaged or dying cells. In this study, we investigated the...
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Catalpol Prevents Glomerular Angiogenesis Induced by Advanced Glycation End Products via Inhibiting Galectin-3
ObjectiveThe main characteristics of diabetic nephropathy (DN) at the early stage are abnormal angiogenesis of glomerular endothelial cells (GECs)...
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Suppression of galectin-4 attenuates peritoneal metastasis of poorly differentiated gastric cancer cells
BackgroundPeritoneal dissemination, most often seen in metastatic and/or recurrent gastric cancer, is an inoperable condition that lacks effective...
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Circulating levels of galectin-3 and coronary microvascular perfusion in rheumatoid arthritis patients with suppressed inflammation
ObjectiveCardiovascular manifestations are the leading cause of mortality in rheumatoid arthritis (RA). Galectin-3, a lectin protein with major role...
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Plasma galectin-9 levels correlate with blood monocyte turnover and predict simian/human immunodeficiency virus disease progression
BackgroundLate-stage human immunodeficiency virus (HIV) infection is typically characterized by low CD4 + T-cell count. We previously showed that...
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A closer look at Galectin-3: its association with gestational diabetes mellitus revealed by systematic review and meta-analysis
PurposeGestational diabetes mellitus (GDM) represents a significant metabolic disorder that affects pregnant women worldwide and has negative...
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Galectin-3 and its correlation with carotid ultrasound in rheumatoid arthritis patients
BackgroundRheumatoid arthritis (RA) is a chronic inflammatory disease resulting in disability as well as joint damage. Early diagnosis and treatment...
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Association of serum galectin-3 levels with mortality and cardiovascular disease outcomes in hemodialysis patients: a systematic review and dose–response meta-analysis
BackgroundGalectin-3 has been proposed as a candidate marker for cardiovascular risk stratification, although its role in kidney failure is unclear....
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Circulating galectin-3 levels are inversely associated with subclinical cardiovascular disease in obese adults
BackgroundGalectin-3 is a new cytokine that is mainly secreted by activated macrophages. It is involved in apoptosis, inflammation and may play a...
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CXC chemokine ligand 13 and galectin-9 plasma levels collaboratively provide prediction of disease activity and progression-free survival in chronic lymphocytic leukemia
The clinical outcome of lymphocytic leukemia (CLL) is quite heterogeneous. The purpose of this observational study was to investigate the clinical...
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Role of galectin-3 as a biomarker in obstructive sleep apnea: a systematic review and meta-analysis
BackgroundBecause obstructive sleep apnea (OSA) is a prevalent condition, biomarkers for OSA would be very useful. Galectin-3 has gained attention as...
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Identification of Galectin-7 as a crucial metastatic enhancer of squamous cell carcinoma associated with immunosuppression
Metastasis predicts poor prognosis in cancer patients. It has been recognized that specific tumor microenvironment defines cancer cell metastasis,...
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T7 peptide-decorated exosome-based nanocarrier system for delivery of Galectin-9 siRNA to stimulate macrophage repolarization in glioblastoma
PurposeExosomes are nano-vesicular carriers capable of delivering cargoes for intercellular communication, which holds potential as biocompatible and...
