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Trajectories of eGFR after kidney transplantation according to trajectories of eGFR prior to kidney replacement therapies in children with chronic kidney disease
BackgroundIn children with chronic kidney disease (CKD), certain risk factors are associated with faster eGFR decline and earlier kidney failure....
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Trajectories of eGFR and risk of albuminuria in youth with type 2 diabetes: results from the TODAY cohort study
BackgroundWe conducted exploratory analyses to identify distinct trajectories of estimated glomerular filtration rate (eGFR) and their relationship...
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Different roles of protein biomarkers predicting eGFR trajectories in people with chronic kidney disease and diabetes mellitus: a nationwide retrospective cohort study
BackgroundChronic kidney disease (CKD) is a common comorbidity in people with diabetes mellitus, and a key risk factor for further life-threatening...
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Incidence of hospital-acquired acute kidney injury and trajectories of glomerular filtration rate in older adults
BackgroundIn older adults, epidemiological data on incidence rates (IR) of hospital-acquired acute kidney injury (AKI) are scarce. Also, little is...
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Kidney function monitoring and trajectories in patients with atrial fibrillation
BackgroundAtrial fibrillation (AF) and chronic kidney disease (CKD) frequently co-exist. The frequency of kidney monitoring and range of kidney...
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Bone health in young adults with type 1 diabetes and progressive eGFR decline
BackgroundType 1 Diabetes (T1D) is associated with increased risk of fractures, worsened by presence of microvascular complications. This study’s...
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Distinct uric acid trajectories are associated with incident cardiac conduction block
BackgroundThe association of longitudinal uric acid (UA) changes with cardiac conduction block risk is unclear. We aimed to identify the trajectories...
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Clinical Outcomes in Patients with CKD and Rapid or Non-rapid eGFR Decline: A Report from the DISCOVER CKD Retrospective Cohort
IntroductionThis analysis examined the baseline characteristics and clinical outcomes of patients with chronic kidney disease (CKD) and rapid or...
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Multi-trajectories of triglyceride-glucose index and lifestyle with Cardiovascular Disease: a cohort study
BackgroundPrevious studies using trajectory models focused on examining the longitudinal changes in triglyceride-glucose (TyG) levels and lifestyle...
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Associations of blood pressure trajectories in early life with target organ damage in midlife : a 30-year cohort study
Hypertension is a pivotal factor in cardiovascular risk. However, the association of longitudinal blood pressure (BP) trajectories in the early life...
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Association of blood pressure trajectories with coronary heart disease among the disabled population in Shanghai, China: a cohort study of 7 years following up
BackgroundMuch less is known about the importance of blood pressure (BP) trajectories concerning the incidence of coronary heart disease (CHD) in...
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Trajectories of atherosclerotic cardiovascular disease risk scores as a predictor for incident chronic kidney disease
BackgroundThe relationship between atherosclerosis and renal function is well established. Atherosclerotic cardiovascular disease (ASCVD) risk scores...
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Tumor suppressor miR-218 directly targets epidermal growth factor receptor (EGFR) expression in triple-negative breast cancer, sensitizing cells to irradiation
PurposeMicroRNA-218 (miR-218) is a key regulator of numerous processes relevant to tumor progression. In the present study, we aimed to characterize...
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Association between triglyceride–glucose index trajectories and radiofrequency ablation outcomes in patients with stage 3D atrial fibrillation
BackgroundThis study investigates the relationship between triglyceride-glucose (TyG) index trajectories and the results of ablation in patients with...
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The relationship between trajectories of renal oxygen saturation and acute kidney injury: a prospective cohort study with a secondary analysis
BackgroundAcute kidney injury (AKI) is a major postoperative consequence, affecting prognosis of older patients. Effective prediction or intervention...
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Association of rate pressure product trajectories at an early age with left ventricular hypertrophy in midlife: a prospective cohort study
The joint effect of blood pressure (BP) and heart rate (HR) on cardiovascular disease is unclear. Rate pressure product (RPP), the product of...
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Microsecond-timescale MD simulation of EGFR minor mutation predicts the structural flexibility of EGFR kinase core that reflects EGFR inhibitor sensitivity
Approximately 15–30% of patients with lung cancer harbor mutations in the EGFR gene. Major EGFR mutations (>90% of EGFR-mutated lung cancer) are...
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Favorable survival outcomes in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer sequentially treated with a tyrosine kinase inhibitor and osimertinib in a real-world setting
PurposeEGFR tyrosine kinase inhibitor (TKI) therapy in EGFR-mutated lung cancer is limited by acquired resistance. In half of the patients treated...
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Importance of reassessment to identify trajectories of chronic transition of clinical indicators in post-myocardial infarction management
Despite advances in multidisciplinary acute care for myocardial infarction (MI), the clinical need to manage heart failure and elevated mortality...
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High serum uric acid trajectories are associated with risk of myocardial infarction and all-cause mortality in general Chinese population
BackgroundLong-term patterns of serum uric acid (SUA) and their association with the risk of myocardial infarction (MI) and mortality are poorly...
