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Assessment of potential drug–drug interaction knowledge, attitude, and practice among Egyptian hospital and community pharmacists: a cross-sectional multicenter study
BackgroundPharmacists have an important role in preventing prescribing errors and providing appropriate information. They can detect potential...
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Development of a Physiologically Based Pharmacokinetic Population Model for Diabetic Patients and its Application to Understand Disease-drug–drug Interactions
IntroductionThe activity changes of cytochrome P450 (CYP450) enzymes, along with the complicated medication scenarios in diabetes mellitus (DM)...
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The Cytokine Release Syndrome and/or the Proinflammatory Cytokines as Underlying Mechanisms of Downregulation of Drug Metabolism and Drug Transport: A Systematic Review of the Clinical Pharmacokinetics of Victim Drugs of this Drug–Disease Interaction Under Different Clinical Conditions
Background and ObjectiveAn ever-growing body of evidence supports the impact of cytokine modulation on the patient’s phenotypic drug response. The...
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Effect of theophylline on stent-related symptoms in patients undergoing Double-J ureteral stent insertion: a randomized controlled trial
PurposeTo investigate the effect of oral theophylline on stent-related syndrome (SRS) after Double-J insertion.
BackgroundDouble-J stent is widely...
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Salivary Therapeutic Drug Monitoring of Antimicrobial Therapy: Feasible or Futile?
Personalised drug dosing through therapeutic drug monitoring (TDM) is important to maximise efficacy and to minimise toxicity. Hurdles preventing...
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Therapeutic drug monitoring in inflammatory bowel disease: A practical approach
The global burden of inflammatory bowel diseases (IBD) is estimated at 4.9 million and the global prevalence exceeds 0.3%. Multiple newer therapeutic...
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Safety and efficacy of IV theophylline for regadenoson-associated side effect reversal
BackgroundAminophylline injection has been on an intermittent nation-wide shortage due to manufacturing delays leaving a need for an alternative...
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The diuretic effect of adding aminophylline or theophylline to furosemide in pediatric populations: a systematic review
The diuretic effect of the combined furosemide and aminophylline/theophylline among pediatric patients remains unclear. The primary aim of this...
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Computational drug repurposing based on electronic health records: a sco** review
Computational drug repurposing methods adapt Artificial intelligence (AI) algorithms for the discovery of new applications of approved or...
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Intensive care drug therapy and its potential adverse effects on blood pressure and heart rate in critically ill children
BackgroundOwing to complex treatment, critically ill children may experience alterations in their vital parameters. We investigated whether such...
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Acute Effects of Coffee Consumption on Blood Pressure and Endothelial Function in Individuals with Hypertension on Antihypertensive Drug Treatment: A Randomized Crossover Trial
IntroductionCoffee is a complex brew that contains several bioactive compounds and some of them can influence blood pressure (BP) and endothelial...
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Using a pilot-centric, qualitative drug risk assessment model to identify opportunities for implementing pharmacogenetics
BackgroundRisk assessment models are at the core of flight medicine, weighing both the impact of the flight environment on an aviator and the...
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Foundations of gastrointestinal-based drug delivery and future developments
Gastrointestinal-based drug delivery is considered the preferred mode of drug administration owing to its convenience for patients, which improves...
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Volume of Distribution is Unaffected by Metabolic Drug–Drug Interactions
IntroductionIt has been recognized that significant transporter interactions result in volume of distribution changes in addition to potential...
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Impact of a drug-related patient-reported outcome measure on drug-related problem identification, physicians’ acceptance, and clinical and quality of life outcomes: a randomized controlled trial
Background : Data are scarce regarding the usefulness of a pharmaceutical therapy-related quality of life measure including the Patient-Reported...
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Development and assessment of PharmaCheck: an electronic screening tool for the prevention of twenty major adverse drug events
BackgroundAdverse drug events (ADEs) can be prevented by deploying clinical decision support systems (CDSS) that directly assist physicians, via...
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Management of drug-disease interactions: a best practice from the Netherlands
Background Drug-disease interactions are situations where pharmacotherapy may have a negative effect on patients’ comorbidities. In these cases, it...
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Herbal Medicine (HM) among pharmacy professionals working in drug retail outlets in Asmara, Eritrea: knowledge, attitude and prevalence of use
BackgroundGlobally, the usage of herbal medicines (HMs) is increasingly growing in treating and preventing various ailments. Although, HMs play a...
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Relevance of mexiletine in the era of evolving antiarrhythmic therapy of ventricular arrhythmias
Despite impressive developments in the field of ventricular arrhythmias, there is still a relevant number of patients with ventricular arrhythmias...
