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Marked intestinal trans-differentiation by autoimmune gastritis along with ectopic pancreatic and pulmonary trans-differentiation
BackgroundAutoimmune gastritis (AIG) is a prevalent chronic inflammatory disease with oncogenic potential that causes destruction of parietal cells...
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Nucleic acid therapeutics as differentiation agents for myeloid leukemias
Differentiation therapy has proven to be a success story for patients with acute promyelocytic leukemia. However, the remaining subtypes of acute...
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MicroRNA-877-5p promotes osteoblast differentiation by targeting EIF4G2 expression
Stimulating bone formation potentially suggests therapeutics for orthopedic diseases including osteoporosis and osteoarthritis. Osteoblasts are key...
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Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis, which is characterized by increased bone...
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GID complex regulates the differentiation of neural stem cells by destabilizing TET2
Brain development requires a delicate balance between self-renewal and differentiation in neural stem cells (NSC), which rely on the precise...
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Nd:YAG-photobiomodulation enhanced ADSCs multilineage differentiation and immunomodulation potentials
To investigate the effects of Nd: YAG (1064 nm) photobiomodulation on multilineage differentiation and immunomodulation potentials of adipose...
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A C/ebpα isoform specific differentiation program in immortalized myelocytes
The transcription factor CCAAT-enhancer binding factor alpha (C/ebpα) is a master controller of myeloid differentiation that is expressed as long...
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GPS2 promotes erythroid differentiation in K562 erythroleukemia cells primarily via NCOR1
G protein pathway suppressor 2 (GPS2) has been shown to play a pivotal role in human and mouse definitive erythropoiesis in an EKLF-dependent manner....
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Grading differentiation in cutaneous squamous cell carcinoma: a review of the literature
Poor differentiation is strongly associated with poor outcomes in cutaneous squamous cell carcinoma (CSCC). In addition, the National Comprehensive...
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circ_0029463 promotes osteoclast differentiation by mediating miR-134-5p/Rab27a axis
ObjectiveOsteoporosis is the imbalance in bone homeostasis between osteoblasts and osteoclasts. In this study, we investigated the effects of the...
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Hypocalcemia in combination with hyperphosphatemia impairs muscle cell differentiation in vitro
PurposeHypoparathyroidism is a rare endocrine disorder characterized by low or absent secretion of parathyroid hormone (PTH), which leads to...
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Type IV Collagen Promotes Adipogenic Differentiation of Adipose Stem Cells
Type IV collagen is a major component of the extracellular matrix in adipose tissue. It is secreted during the lipogenic differentiation of...
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The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma
Rhabdomyosarcoma tumor cells resemble differentiating skeletal muscle cells, which unlike normal muscle cells, fail to undergo terminal...
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Mir-4699 promotes the osteogenic differentiation of mesenchymal stem cells
IntroductionMesenchymal stem cells (MSCs) are drawing considerable attention in the field of regenerative medicine due to their differentiation...
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Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy
T cell differentiation is a highly regulated, multi-step process necessary for the progressive establishment of effector functions, immunological...
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Extracorporeal shock wave therapy inhibits osteoclast differentiation by targeting NF-κB signaling pathway
BackgroundExtracorporeal shock wave therapy (ESWT) has been reported to promote osteoblast differentiation. However, the role of ESWT on osteoclast...
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A Gelatin-Based Biomimetic Scaffold Promoting Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells
BackgroundIn bone tissue engineering segment, numerous approaches have been investigated to address critically sized bone defects via 3D scaffolds,...
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The effect of nanomaterials on embryonic stem cell neural differentiation: a systematic review
BackgroundHumans’ nervous system has a limited ability to repair nerve cells, which poses substantial challenges in treating injuries and diseases....
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HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation
Bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation and osteoblast function play critical roles in bone formation, which is a highly...
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BRD4 facilitates osteogenic differentiation of human bone marrow mesenchymal stem cells through WNT4/NF-κB pathway
BackgroundHuman bone marrow mesenchymal stem cells (hBMSCs) are a major source of osteoblast precursor cells and are directly involved in...
