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Transcript shortening via alternative polyadenylation promotes gene expression during fracture healing
Maturation of the 3′ end of almost all eukaryotic messenger RNAs (mRNAs) requires cleavage and polyadenylation. Most mammalian mRNAs are...
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Novel thrombospondin-1 transcript exhibits distinctive expression and activity in thyroid tumorigenesis
Thrombospondin 1 (TSP1) is known for its cell-specific functions in cancer progression, such as proliferation and migration. It contains 22 exons...
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Differential microRNA expression analyses across two brain regions in Alzheimer’s disease
Dysregulation of microRNAs (miRNAs) is involved in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD). Hitherto,...
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Differential expression profiles and functional analysis of long non-coding RNAs in calcific aortic valve disease
AimTo evaluate the expression profile of long non-coding RNAs (lncRNAs) in calcific aortic valve disease (CAVD) and explore their potential mechanism...
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Genes implicated by a methylome-wide schizophrenia study in neonatal blood show differential expression in adult brain samples
Schizophrenia is a disabling disorder involving genetic predisposition in combination with environmental influences that likely act via dynamic...
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Differential Expression of Super-Enhancer-Associated Long Non-coding RNAs in Uterine Leiomyomas
Super-enhancer-associated long non-coding RNAs (SE-lncRNAs) are a specific set of lncRNAs transcribed from super-enhancer (SE) genomic regions....
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Transplantation of gut microbiota derived from patients with schizophrenia induces schizophrenia-like behaviors and dysregulated brain transcript response in mice
Schizophrenia (SCZ), as a neurodevelopmental disorder and devastating disease, affects approximately 1% of the world population. Although numerous...
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Leukocyte differential gene expression prognostic value for high versus low seizure frequency in temporal lobe epilepsy
BackgroundThis study was performed to test the hypothesis that systemic leukocyte gene expression has prognostic value differentiating low from high...
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A deep intronic variant in DNM1 in a patient with developmental and epileptic encephalopathy creates a splice acceptor site and affects only transcript variants including exon 10a
DNM1 developmental and epileptic encephalopathy (DEE) is characterized by severe to profound intellectual disability, hypotonia, movement disorder,...
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Tight gene co-expression in BCB positive cattle oocytes and their surrounding cumulus cells
BackgroundCytoplasmic and nuclear maturation of oocytes, as well as interaction with the surrounding cumulus cells, are important features relevant...
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Immunoglobulin light chain transcript detection by ultrasensitive RNA in situ hybridization for B-cell lymphoma diagnosis
Evaluation of B-cell clonality can be challenging in the interpretation of lymphoid infiltrates on tissue sections. Clonality testing based on IG ...
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Transcript host-RNA signatures to discriminate bacterial and viral infections in febrile children
AbstractTraditional laboratory markers, such as white blood cell count, C-reactive protein, and procalcitonin, failed to discriminate viral and...
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G3BP2 regulated by the lncRNA LINC01554 facilitates esophageal squamous cell carcinoma metastasis through stabilizing HDGF transcript
Metastasis is the leading cause of death of patients with esophageal squamous cell carcinoma (ESCC). Although an increasing number of studies have...
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A study of differential microRNA expression profile in migraine: the microMIG exploratory study
BackgroundSeveral studies have described potential microRNA (miRNA) biomarkers associated with migraine, but studies are scarcely reproducible...
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MicroRNA expression associated with low-grade cervical intraepithelial neoplasia outcomes
PurposeOnly a fraction of low-grade cervical intraepithelial neoplasia (CIN) progresses to high-grade CIN; however, the biological processes that...
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Cell-type and sex-specific rhythmic gene expression in the nucleus accumbens
Circadian rhythms are critical for human health and are highly conserved across species. Disruptions in these rhythms contribute to many diseases,...
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Differential Gene Regulation of the Human Blastocyst Trophectoderm and Inner Cell Mass by Progesterone
Knowledge of action of progesterone (P4) on the human preimplantation embryo is lacking. The objective of this study was to determine expression of a...
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High expression of ABCF1 is an independent predictor of poor prognosis in bladder cancer
ABCF1, a member of the ATP-binding cassette (ABC) transporter family, is involved in the malignant progression of tumors. However, the role of ABCF1...
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Bronchial epithelial gene expression and interstitial lung abnormalities
IntroductionInterstitial lung abnormalities (ILA) often represent early fibrotic changes that can portend a progressive fibrotic phenotype. In...
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Differential expression profiling of onco and tumor-suppressor genes from major-signaling pathways in Wilms’ tumor
PurposeWilms’ tumor is the most-frequent malignant-kidney tumor in children under 3–4 years of age and is caused by genetic alterations of oncogenes...
